Study on the antifungal potential of Piper betle methanol extract against Colletotrichum gloeosporioides cutinase
Piper betle methanol extract and its compositional characteristics had been evidenced for their effective inhibitability against rice-blast fungus. In this work, they were subjected for further computational efforts to complete their bio-chemo-pharmacological profile, and broaden their anti-fungal...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
HUJOS
2024-06-01
|
| Series: | Tạp chí Khoa học Đại học Huế: Khoa học Tự nhiên |
| Subjects: | |
| Online Access: | https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/7459 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832557869582516224 |
|---|---|
| author | Nhung Nguyen Thi Ai Hai Nguyen Thi Thanh Quang Thanh Bui Vinh Phu Nguyen Tu Quy Phan |
| author_facet | Nhung Nguyen Thi Ai Hai Nguyen Thi Thanh Quang Thanh Bui Vinh Phu Nguyen Tu Quy Phan |
| author_sort | Nhung Nguyen Thi Ai |
| collection | DOAJ |
| description |
Piper betle methanol extract and its compositional characteristics had been evidenced for their effective inhibitability against rice-blast fungus. In this work, they were subjected for further computational efforts to complete their bio-chemo-pharmacological profile, and broaden their anti-fungal potentiality against Colletotrichum gloeosporioides cutinase presentative (PDB-3DEA). As the results, the most noticeable promising inhibitors particularly regard to 5 (DS -10.8 kcal.mol-1; ground-state energy -499.50 a.u.; dipole moment 2.61 Debye; no toxicity; content 49.90 %) and 6 (DS -10.9 kcal.mol-1; ground-state energy -652.15 a.u.; dipole moment 2.82 Debye; no toxicity; content 13.23 %), given by both their natural contents and predicted properties. The theoretical retrievals would reinforce the antifungal activities of P. betle and be conducive to further efforts to develop a green fungicidal alternative with broad-spectrum and cost-effective pesticidal advantages.
|
| format | Article |
| id | doaj-art-fd2ec757bbcd4e69834d61d86cdaf81a |
| institution | Kabale University |
| issn | 1859-1388 2615-9678 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | HUJOS |
| record_format | Article |
| series | Tạp chí Khoa học Đại học Huế: Khoa học Tự nhiên |
| spelling | doaj-art-fd2ec757bbcd4e69834d61d86cdaf81a2025-02-03T01:56:49ZengHUJOSTạp chí Khoa học Đại học Huế: Khoa học Tự nhiên1859-13882615-96782024-06-011331B10.26459/hueunijns.v133i1B.7459Study on the antifungal potential of Piper betle methanol extract against Colletotrichum gloeosporioides cutinaseNhung Nguyen Thi Ai0Hai Nguyen Thi Thanh1Quang Thanh Bui2Vinh Phu Nguyen3Tu Quy Phan4Department of Chemistry, University of Sciences, Hue University, Hue, VietnamDepartment of Chemistry, University of Sciences, Hue University, Hue, VietnamDepartment of Chemistry, University of Sciences, Hue University, Hue, VietnamFaculty of Basic Sciences, University of Medicine and Pharmacy, Hue University, Hue, VietnamDepartment of Natural Sciences & Technology, Tay Nguyen University, Buon Ma Thuot, Vietnam Piper betle methanol extract and its compositional characteristics had been evidenced for their effective inhibitability against rice-blast fungus. In this work, they were subjected for further computational efforts to complete their bio-chemo-pharmacological profile, and broaden their anti-fungal potentiality against Colletotrichum gloeosporioides cutinase presentative (PDB-3DEA). As the results, the most noticeable promising inhibitors particularly regard to 5 (DS -10.8 kcal.mol-1; ground-state energy -499.50 a.u.; dipole moment 2.61 Debye; no toxicity; content 49.90 %) and 6 (DS -10.9 kcal.mol-1; ground-state energy -652.15 a.u.; dipole moment 2.82 Debye; no toxicity; content 13.23 %), given by both their natural contents and predicted properties. The theoretical retrievals would reinforce the antifungal activities of P. betle and be conducive to further efforts to develop a green fungicidal alternative with broad-spectrum and cost-effective pesticidal advantages. https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/7459Piper betle LColletotrichum gloeosporioidein silicoethanol extractfungicidal alternative |
| spellingShingle | Nhung Nguyen Thi Ai Hai Nguyen Thi Thanh Quang Thanh Bui Vinh Phu Nguyen Tu Quy Phan Study on the antifungal potential of Piper betle methanol extract against Colletotrichum gloeosporioides cutinase Tạp chí Khoa học Đại học Huế: Khoa học Tự nhiên Piper betle L Colletotrichum gloeosporioide in silico ethanol extract fungicidal alternative |
| title | Study on the antifungal potential of Piper betle methanol extract against Colletotrichum gloeosporioides cutinase |
| title_full | Study on the antifungal potential of Piper betle methanol extract against Colletotrichum gloeosporioides cutinase |
| title_fullStr | Study on the antifungal potential of Piper betle methanol extract against Colletotrichum gloeosporioides cutinase |
| title_full_unstemmed | Study on the antifungal potential of Piper betle methanol extract against Colletotrichum gloeosporioides cutinase |
| title_short | Study on the antifungal potential of Piper betle methanol extract against Colletotrichum gloeosporioides cutinase |
| title_sort | study on the antifungal potential of piper betle methanol extract against colletotrichum gloeosporioides cutinase |
| topic | Piper betle L Colletotrichum gloeosporioide in silico ethanol extract fungicidal alternative |
| url | https://jos.hueuni.edu.vn/index.php/hujos-ns/article/view/7459 |
| work_keys_str_mv | AT nhungnguyenthiai studyontheantifungalpotentialofpiperbetlemethanolextractagainstcolletotrichumgloeosporioidescutinase AT hainguyenthithanh studyontheantifungalpotentialofpiperbetlemethanolextractagainstcolletotrichumgloeosporioidescutinase AT quangthanhbui studyontheantifungalpotentialofpiperbetlemethanolextractagainstcolletotrichumgloeosporioidescutinase AT vinhphunguyen studyontheantifungalpotentialofpiperbetlemethanolextractagainstcolletotrichumgloeosporioidescutinase AT tuquyphan studyontheantifungalpotentialofpiperbetlemethanolextractagainstcolletotrichumgloeosporioidescutinase |