Multifunctional Triamcinolone Acetonide Microneedle Patches for Atopic Dermatitis Treatment
Atopic dermatitis (AD), a chronic and inflammatory skin disease, has brought huge physiological and psychological burdens to patients, which causes wide concerns in society. Herein, a multifunctional microneedle (MN) patch is proposed integrated with a desirable moisturizer and intelligent drug deli...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2024-12-01
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| Series: | Small Structures |
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| Online Access: | https://doi.org/10.1002/sstr.202400302 |
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| author | Liwan Song Lu Fan Qingfei Zhang Shanshan Huang Bin Kong Jian Xiao Ye Xu |
| author_facet | Liwan Song Lu Fan Qingfei Zhang Shanshan Huang Bin Kong Jian Xiao Ye Xu |
| author_sort | Liwan Song |
| collection | DOAJ |
| description | Atopic dermatitis (AD), a chronic and inflammatory skin disease, has brought huge physiological and psychological burdens to patients, which causes wide concerns in society. Herein, a multifunctional microneedle (MN) patch is proposed integrated with a desirable moisturizer and intelligent drug delivery capacity for AD treatment. Such MN patch consists of hyaluronic acid (HA) backing and near‐infrared (NIR) responsive tips containing black phosphorous quantum dots (BPQDs), low‐melting agarose, polyvinylpyrrolidone (PVP), and triamcinolone acetonide (TA). Among them, the soluble HA serves as a long‐term moisturizer for relieving dryness symptoms of AD. By introducing the NIR excitable and photothermal responsive BPQDs into agarose, the state of the composite material can be adjusted intelligently via NIR, thus achieving controllable release of the encapsulated TA in tips. Besides, PVP with enough mechanical strength can help MNs successfully penetrate the thickened skin of AD patients. Based on these advantages, it is demonstrated that the multifunctional MN patch reveals a satisfactory therapeutic effect in the AD model of Balb/c mice. These results indicate the potential values of the proposed MN patch in the treatment of AD skin diseases and other related biomedical fields. |
| format | Article |
| id | doaj-art-fd2dcba49ef2404d8cda00fd18c4f15a |
| institution | OA Journals |
| issn | 2688-4062 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Structures |
| spelling | doaj-art-fd2dcba49ef2404d8cda00fd18c4f15a2025-08-20T02:19:33ZengWiley-VCHSmall Structures2688-40622024-12-01512n/an/a10.1002/sstr.202400302Multifunctional Triamcinolone Acetonide Microneedle Patches for Atopic Dermatitis TreatmentLiwan Song0Lu Fan1Qingfei Zhang2Shanshan Huang3Bin Kong4Jian Xiao5Ye Xu6Department of Burns and Plastic Surgery Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing 210096 ChinaDepartment of Burns and Plastic Surgery Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing 210096 ChinaWenzhou Institute University of Chinese Academy of Sciences Wenzhou Zhejiang 325001 ChinaDepartment of Wound Healing The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325015 ChinaDepartment of Burns and Plastic Surgery Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing 210096 ChinaWenzhou Institute University of Chinese Academy of Sciences Wenzhou Zhejiang 325001 ChinaDepartment of Burns and Plastic Surgery Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing 210096 ChinaAtopic dermatitis (AD), a chronic and inflammatory skin disease, has brought huge physiological and psychological burdens to patients, which causes wide concerns in society. Herein, a multifunctional microneedle (MN) patch is proposed integrated with a desirable moisturizer and intelligent drug delivery capacity for AD treatment. Such MN patch consists of hyaluronic acid (HA) backing and near‐infrared (NIR) responsive tips containing black phosphorous quantum dots (BPQDs), low‐melting agarose, polyvinylpyrrolidone (PVP), and triamcinolone acetonide (TA). Among them, the soluble HA serves as a long‐term moisturizer for relieving dryness symptoms of AD. By introducing the NIR excitable and photothermal responsive BPQDs into agarose, the state of the composite material can be adjusted intelligently via NIR, thus achieving controllable release of the encapsulated TA in tips. Besides, PVP with enough mechanical strength can help MNs successfully penetrate the thickened skin of AD patients. Based on these advantages, it is demonstrated that the multifunctional MN patch reveals a satisfactory therapeutic effect in the AD model of Balb/c mice. These results indicate the potential values of the proposed MN patch in the treatment of AD skin diseases and other related biomedical fields.https://doi.org/10.1002/sstr.202400302atopic dermatitisdrug deliveryhydrogelsmicroneedle patchesresponsiveness |
| spellingShingle | Liwan Song Lu Fan Qingfei Zhang Shanshan Huang Bin Kong Jian Xiao Ye Xu Multifunctional Triamcinolone Acetonide Microneedle Patches for Atopic Dermatitis Treatment Small Structures atopic dermatitis drug delivery hydrogels microneedle patches responsiveness |
| title | Multifunctional Triamcinolone Acetonide Microneedle Patches for Atopic Dermatitis Treatment |
| title_full | Multifunctional Triamcinolone Acetonide Microneedle Patches for Atopic Dermatitis Treatment |
| title_fullStr | Multifunctional Triamcinolone Acetonide Microneedle Patches for Atopic Dermatitis Treatment |
| title_full_unstemmed | Multifunctional Triamcinolone Acetonide Microneedle Patches for Atopic Dermatitis Treatment |
| title_short | Multifunctional Triamcinolone Acetonide Microneedle Patches for Atopic Dermatitis Treatment |
| title_sort | multifunctional triamcinolone acetonide microneedle patches for atopic dermatitis treatment |
| topic | atopic dermatitis drug delivery hydrogels microneedle patches responsiveness |
| url | https://doi.org/10.1002/sstr.202400302 |
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