Revolutionizing cancer treatment: engineering mesenchymal stem cell-derived small extracellular vesicles
Abstract In recent years, use of exosomes is one of the important approaches to treat cancer. Mesenchymal stem cells are multipotent stem cells which are very putative sources for modulating the immune system and importantly inhibiting immune responses against tumor cells. Small extracellular vesicl...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | Cancer Cell International |
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| Online Access: | https://doi.org/10.1186/s12935-025-03900-0 |
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| author | Ameneh Shokati Mahshid Akhavan Rahnama Ladan Jalali Saghar Hoseinzadeh Saman Masoudifar Mohammad Ahmadvand |
| author_facet | Ameneh Shokati Mahshid Akhavan Rahnama Ladan Jalali Saghar Hoseinzadeh Saman Masoudifar Mohammad Ahmadvand |
| author_sort | Ameneh Shokati |
| collection | DOAJ |
| description | Abstract In recent years, use of exosomes is one of the important approaches to treat cancer. Mesenchymal stem cells are multipotent stem cells which are very putative sources for modulating the immune system and importantly inhibiting immune responses against tumor cells. Small extracellular vesicles (small EVs) are extracted from mesenchymal stem cells can have therapeutic approaches for delivering targeted drugs to cancer cells and also tumors via regulation of signaling pathways. There are challenges in use of exosomes in cancer treatment which need to be improved. Engineering in small EVs can recover the role of exosomes such as drug delivery and therapeutic tools. There are preclinical and clinical studies in the field of mesenchymal stem cells derived from small EVs which demonstrates efficacy of these approaches in the field of cancer. In consideration of problems in large scale production and so on, engineered small EVs as treatment approaches for cancers, it is resulted that they retain most characteristics of cells which are derived from, are responsible for their immunomodulatory impacts driving positive changes in the tumor microenvironment. |
| format | Article |
| id | doaj-art-fd2c8210fdc64c7c8ccf43472251a51b |
| institution | Kabale University |
| issn | 1475-2867 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj-art-fd2c8210fdc64c7c8ccf43472251a51b2025-08-20T03:43:36ZengBMCCancer Cell International1475-28672025-07-0125112110.1186/s12935-025-03900-0Revolutionizing cancer treatment: engineering mesenchymal stem cell-derived small extracellular vesiclesAmeneh Shokati0Mahshid Akhavan Rahnama1Ladan Jalali2Saghar Hoseinzadeh3Saman Masoudifar4Mohammad Ahmadvand5Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical SciencesCell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Research Institute for Oncology, Hematology and Cell Therapy, Tehran University of Medical SciencesDepartment of Biochemistry, School of Medicine, Urmia University of Medical SciencesDepartment of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical SciencesBlood Transfusion Research Center, High Institute for Research and Education in Transfusion MedicineCell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Research Institute for Oncology, Hematology and Cell Therapy, Tehran University of Medical SciencesAbstract In recent years, use of exosomes is one of the important approaches to treat cancer. Mesenchymal stem cells are multipotent stem cells which are very putative sources for modulating the immune system and importantly inhibiting immune responses against tumor cells. Small extracellular vesicles (small EVs) are extracted from mesenchymal stem cells can have therapeutic approaches for delivering targeted drugs to cancer cells and also tumors via regulation of signaling pathways. There are challenges in use of exosomes in cancer treatment which need to be improved. Engineering in small EVs can recover the role of exosomes such as drug delivery and therapeutic tools. There are preclinical and clinical studies in the field of mesenchymal stem cells derived from small EVs which demonstrates efficacy of these approaches in the field of cancer. In consideration of problems in large scale production and so on, engineered small EVs as treatment approaches for cancers, it is resulted that they retain most characteristics of cells which are derived from, are responsible for their immunomodulatory impacts driving positive changes in the tumor microenvironment.https://doi.org/10.1186/s12935-025-03900-0Mesenchymal stem cellsEngineered extracellular vesiclesCancer |
| spellingShingle | Ameneh Shokati Mahshid Akhavan Rahnama Ladan Jalali Saghar Hoseinzadeh Saman Masoudifar Mohammad Ahmadvand Revolutionizing cancer treatment: engineering mesenchymal stem cell-derived small extracellular vesicles Cancer Cell International Mesenchymal stem cells Engineered extracellular vesicles Cancer |
| title | Revolutionizing cancer treatment: engineering mesenchymal stem cell-derived small extracellular vesicles |
| title_full | Revolutionizing cancer treatment: engineering mesenchymal stem cell-derived small extracellular vesicles |
| title_fullStr | Revolutionizing cancer treatment: engineering mesenchymal stem cell-derived small extracellular vesicles |
| title_full_unstemmed | Revolutionizing cancer treatment: engineering mesenchymal stem cell-derived small extracellular vesicles |
| title_short | Revolutionizing cancer treatment: engineering mesenchymal stem cell-derived small extracellular vesicles |
| title_sort | revolutionizing cancer treatment engineering mesenchymal stem cell derived small extracellular vesicles |
| topic | Mesenchymal stem cells Engineered extracellular vesicles Cancer |
| url | https://doi.org/10.1186/s12935-025-03900-0 |
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