Design and Structure of a Non-Coaxial Multi-Focal Composite Fresnel Acoustic Lens for Synergistic Ultrasound Stimulation of Multiple Brain Regions
Transcranial focused ultrasound (TcFUS) neuromodulation is hindered by skull-induced acoustic limitations. To enable synergistic multi-region brain stimulation, we designed non-coaxial multi-focal composite Fresnel acoustic lenses, including an overlapping Fresnel lens (OFL) and an alternating-segme...
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MDPI AG
2025-05-01
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| author | Ruiqi Wu Fangfang Shi Juan Tao Jiajia Zhao Jinying Zhang Xianmei Wu Jingjing Xu |
| author_facet | Ruiqi Wu Fangfang Shi Juan Tao Jiajia Zhao Jinying Zhang Xianmei Wu Jingjing Xu |
| author_sort | Ruiqi Wu |
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| description | Transcranial focused ultrasound (TcFUS) neuromodulation is hindered by skull-induced acoustic limitations. To enable synergistic multi-region brain stimulation, we designed non-coaxial multi-focal composite Fresnel acoustic lenses, including an overlapping Fresnel lens (OFL) and an alternating-segmented Fresnel lens (ASFL). These lenses convert planar ultrasound into multiple foci. Based on Fresnel theory, acoustic fields were analyzed via simulations and experiments, validating the generation of four non-coaxial foci (10/30 mm focal lengths) from a 1 MHz planar wave using both OFL and ASFL. The influence of lens parameters on focal pressure distribution was investigated, and morphology was quantified using a linear least-squares method. Significant differences in focal morphology and intensity between OFL and ASFL provide crucial guidance for optimizing multi-target TcFUS strategies. |
| format | Article |
| id | doaj-art-fd25f1af9c0d42e7af0e3086e12d7279 |
| institution | OA Journals |
| issn | 1424-8220 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Sensors |
| spelling | doaj-art-fd25f1af9c0d42e7af0e3086e12d72792025-08-20T02:32:56ZengMDPI AGSensors1424-82202025-05-012511329910.3390/s25113299Design and Structure of a Non-Coaxial Multi-Focal Composite Fresnel Acoustic Lens for Synergistic Ultrasound Stimulation of Multiple Brain RegionsRuiqi Wu0Fangfang Shi1Juan Tao2Jiajia Zhao3Jinying Zhang4Xianmei Wu5Jingjing Xu6School of Integrated Circuits, Shandong University, Jinan 250101, ChinaState Key Laboratory of Acoustics and Marine Information, Institute of Acoustics, Chinese Academy of Sciences, Beijing 100190, ChinaSchool of Integrated Circuits, Shandong University, Jinan 250101, ChinaSchool of Integrated Circuits, Shandong University, Jinan 250101, ChinaBeijing Key Laboratory for Precision Optoelectronic Measurement Instrument and Technology, School of Optics and Photonics, Beijing Institute of Technology, Beijing 100081, ChinaState Key Laboratory of Acoustics and Marine Information, Institute of Acoustics, Chinese Academy of Sciences, Beijing 100190, ChinaSchool of Integrated Circuits, Shandong University, Jinan 250101, ChinaTranscranial focused ultrasound (TcFUS) neuromodulation is hindered by skull-induced acoustic limitations. To enable synergistic multi-region brain stimulation, we designed non-coaxial multi-focal composite Fresnel acoustic lenses, including an overlapping Fresnel lens (OFL) and an alternating-segmented Fresnel lens (ASFL). These lenses convert planar ultrasound into multiple foci. Based on Fresnel theory, acoustic fields were analyzed via simulations and experiments, validating the generation of four non-coaxial foci (10/30 mm focal lengths) from a 1 MHz planar wave using both OFL and ASFL. The influence of lens parameters on focal pressure distribution was investigated, and morphology was quantified using a linear least-squares method. Significant differences in focal morphology and intensity between OFL and ASFL provide crucial guidance for optimizing multi-target TcFUS strategies.https://www.mdpi.com/1424-8220/25/11/3299transcranial focused ultrasoundFresnel zone platesnon-coaxial focusingacoustic lens |
| spellingShingle | Ruiqi Wu Fangfang Shi Juan Tao Jiajia Zhao Jinying Zhang Xianmei Wu Jingjing Xu Design and Structure of a Non-Coaxial Multi-Focal Composite Fresnel Acoustic Lens for Synergistic Ultrasound Stimulation of Multiple Brain Regions Sensors transcranial focused ultrasound Fresnel zone plates non-coaxial focusing acoustic lens |
| title | Design and Structure of a Non-Coaxial Multi-Focal Composite Fresnel Acoustic Lens for Synergistic Ultrasound Stimulation of Multiple Brain Regions |
| title_full | Design and Structure of a Non-Coaxial Multi-Focal Composite Fresnel Acoustic Lens for Synergistic Ultrasound Stimulation of Multiple Brain Regions |
| title_fullStr | Design and Structure of a Non-Coaxial Multi-Focal Composite Fresnel Acoustic Lens for Synergistic Ultrasound Stimulation of Multiple Brain Regions |
| title_full_unstemmed | Design and Structure of a Non-Coaxial Multi-Focal Composite Fresnel Acoustic Lens for Synergistic Ultrasound Stimulation of Multiple Brain Regions |
| title_short | Design and Structure of a Non-Coaxial Multi-Focal Composite Fresnel Acoustic Lens for Synergistic Ultrasound Stimulation of Multiple Brain Regions |
| title_sort | design and structure of a non coaxial multi focal composite fresnel acoustic lens for synergistic ultrasound stimulation of multiple brain regions |
| topic | transcranial focused ultrasound Fresnel zone plates non-coaxial focusing acoustic lens |
| url | https://www.mdpi.com/1424-8220/25/11/3299 |
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