Design and Structure of a Non-Coaxial Multi-Focal Composite Fresnel Acoustic Lens for Synergistic Ultrasound Stimulation of Multiple Brain Regions
Transcranial focused ultrasound (TcFUS) neuromodulation is hindered by skull-induced acoustic limitations. To enable synergistic multi-region brain stimulation, we designed non-coaxial multi-focal composite Fresnel acoustic lenses, including an overlapping Fresnel lens (OFL) and an alternating-segme...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
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| Series: | Sensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8220/25/11/3299 |
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| Summary: | Transcranial focused ultrasound (TcFUS) neuromodulation is hindered by skull-induced acoustic limitations. To enable synergistic multi-region brain stimulation, we designed non-coaxial multi-focal composite Fresnel acoustic lenses, including an overlapping Fresnel lens (OFL) and an alternating-segmented Fresnel lens (ASFL). These lenses convert planar ultrasound into multiple foci. Based on Fresnel theory, acoustic fields were analyzed via simulations and experiments, validating the generation of four non-coaxial foci (10/30 mm focal lengths) from a 1 MHz planar wave using both OFL and ASFL. The influence of lens parameters on focal pressure distribution was investigated, and morphology was quantified using a linear least-squares method. Significant differences in focal morphology and intensity between OFL and ASFL provide crucial guidance for optimizing multi-target TcFUS strategies. |
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| ISSN: | 1424-8220 |