CCR2 restricts IFN-γ production by hippocampal CD8 TRM cells that impair learning and memory during recovery from WNV encephalitis

CCR2 restricts IFN-γ production by hippocampal CD8 TRM cells that impair learning and memory during recovery from WNV encephalitis

Abstract Central nervous system (CNS) resident memory CD8 T cells (TRM) that express IFN-γ contribute to neurodegenerative processes, including synapse loss, leading to memory impairment. Here, we show that CCR2 signaling in CD8 TRM that persist within the hippocampus after recovery from CNS infecti...

Full description

Saved in:
Bibliographic Details
Main Authors: Shenjian Ai, Artem Arutyunov, Joshua Liu, Jeremy D. Hill, Xiaoping Jiang, Robyn S. Klein
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-024-03309-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items