Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes
Steroidal compounds exhibit particular physiological activities. In this paper, some steroidal thiosemicarbazones platinum (Pt(II)) complexes were synthesized by the condensation of steroidal ketones with thiosemicarbazide using estrone, chenodeoxycholic acid, and 7-deoxycholic acid as starting mate...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2015/742592 |
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| author | Yanmin Huang Erbin Kong Chunfang Gan Zhiping Liu Qifu Lin Jianguo Cui |
| author_facet | Yanmin Huang Erbin Kong Chunfang Gan Zhiping Liu Qifu Lin Jianguo Cui |
| author_sort | Yanmin Huang |
| collection | DOAJ |
| description | Steroidal compounds exhibit particular physiological activities. In this paper, some steroidal thiosemicarbazones platinum (Pt(II)) complexes were synthesized by the condensation of steroidal ketones with thiosemicarbazide using estrone, chenodeoxycholic acid, and 7-deoxycholic acid as starting materials and complexation of steroidal thiosesemicarbazones with Pt(II). The complexes were characterized by IR, NMR, and MS, and their antiproliferative activities were evaluated. The results showed that some steroidal thiosemicarbazones platinum (Pt(II)) complexes displayed moderate cytotoxicity to HeLa and Bel-7404 cells. Thereinto, complex 6 showed an excellent inhibited selectivity to HeLa cells with an IC50 value of 9.2 μM and SI value of 21.7. At the same time, all compounds were almost inactive to HEK293T (normal kidney epithelial cells). The information obtained from the studies may be useful for the design of novel chemotherapeutic drugs. |
| format | Article |
| id | doaj-art-fd16dc15ffda4036ba0afe93e538ac69 |
| institution | OA Journals |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-fd16dc15ffda4036ba0afe93e538ac692025-08-20T02:22:40ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2015-01-01201510.1155/2015/742592742592Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) ComplexesYanmin Huang0Erbin Kong1Chunfang Gan2Zhiping Liu3Qifu Lin4Jianguo Cui5College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, ChinaCollege of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, ChinaCollege of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, ChinaCollege of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, ChinaGuangxi Colleges and University Key Laboratory of Beibu Gulf Oil and Natural Gas Resource Effective Utilization, Qizhou University, Qizhou 535000, ChinaCollege of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, ChinaSteroidal compounds exhibit particular physiological activities. In this paper, some steroidal thiosemicarbazones platinum (Pt(II)) complexes were synthesized by the condensation of steroidal ketones with thiosemicarbazide using estrone, chenodeoxycholic acid, and 7-deoxycholic acid as starting materials and complexation of steroidal thiosesemicarbazones with Pt(II). The complexes were characterized by IR, NMR, and MS, and their antiproliferative activities were evaluated. The results showed that some steroidal thiosemicarbazones platinum (Pt(II)) complexes displayed moderate cytotoxicity to HeLa and Bel-7404 cells. Thereinto, complex 6 showed an excellent inhibited selectivity to HeLa cells with an IC50 value of 9.2 μM and SI value of 21.7. At the same time, all compounds were almost inactive to HEK293T (normal kidney epithelial cells). The information obtained from the studies may be useful for the design of novel chemotherapeutic drugs.http://dx.doi.org/10.1155/2015/742592 |
| spellingShingle | Yanmin Huang Erbin Kong Chunfang Gan Zhiping Liu Qifu Lin Jianguo Cui Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes Bioinorganic Chemistry and Applications |
| title | Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes |
| title_full | Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes |
| title_fullStr | Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes |
| title_full_unstemmed | Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes |
| title_short | Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes |
| title_sort | synthesis and antiproliferative activity of steroidal thiosemicarbazone platinum pt ii complexes |
| url | http://dx.doi.org/10.1155/2015/742592 |
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