Synthesis and Antimicrobial Activity of Some New Thiazolidin-4-one Derivatives of 4-(6-methylbenzo[d]thiazol-2-yl)benzamine
A number of derivatives of 2-(substituted phenyl)-3-(4-(6-methylbenzo[d]thiazol-2-yl)phenyl) thiazolidin-4-one (3a–j) have been synthesized from the reaction of 4-(6-methylbenzo[d]thiazol-2-yl)benzenamine(1), with different substituted benzaldehydes (2a–j), followed by cyclocondensation reaction...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/185952 |
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| author | Awaz Jamil Hussein Hashim Jalal Azeez |
| author_facet | Awaz Jamil Hussein Hashim Jalal Azeez |
| author_sort | Awaz Jamil Hussein |
| collection | DOAJ |
| description | A number of derivatives of 2-(substituted phenyl)-3-(4-(6-methylbenzo[d]thiazol-2-yl)phenyl) thiazolidin-4-one (3a–j) have been synthesized from the reaction of 4-(6-methylbenzo[d]thiazol-2-yl)benzenamine(1), with different substituted benzaldehydes (2a–j), followed by cyclocondensation reaction of the prepared imines with 2-meraptoacetic acid in high yields. Furthermore, the structures of the newly synthesized compounds were confirmed by FT-IR, 13C-NMR,13C-DEPT, and 1H-NMR spectral data. The imines and thiazolidin-4-one derivatives were evaluated for their antibacterial activity against Escherichia coli as gram negative and Staphylococcus aureus as gram positive, the results have shown significant activity against both types of bacteria. |
| format | Article |
| id | doaj-art-fd0cf7eba4374d889546e7fab1ccf244 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-fd0cf7eba4374d889546e7fab1ccf2442025-08-20T03:25:50ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/185952185952Synthesis and Antimicrobial Activity of Some New Thiazolidin-4-one Derivatives of 4-(6-methylbenzo[d]thiazol-2-yl)benzamineAwaz Jamil Hussein0Hashim Jalal Azeez1Department of Chemistry, College of Education-Scientific Deptartment, Salahaddin University, Hawler, Kurdistan, Arbil, IraqDepartment of Chemistry, College of Education-Scientific Deptartment, Salahaddin University, Hawler, Kurdistan, Arbil, IraqA number of derivatives of 2-(substituted phenyl)-3-(4-(6-methylbenzo[d]thiazol-2-yl)phenyl) thiazolidin-4-one (3a–j) have been synthesized from the reaction of 4-(6-methylbenzo[d]thiazol-2-yl)benzenamine(1), with different substituted benzaldehydes (2a–j), followed by cyclocondensation reaction of the prepared imines with 2-meraptoacetic acid in high yields. Furthermore, the structures of the newly synthesized compounds were confirmed by FT-IR, 13C-NMR,13C-DEPT, and 1H-NMR spectral data. The imines and thiazolidin-4-one derivatives were evaluated for their antibacterial activity against Escherichia coli as gram negative and Staphylococcus aureus as gram positive, the results have shown significant activity against both types of bacteria.http://dx.doi.org/10.1155/2013/185952 |
| spellingShingle | Awaz Jamil Hussein Hashim Jalal Azeez Synthesis and Antimicrobial Activity of Some New Thiazolidin-4-one Derivatives of 4-(6-methylbenzo[d]thiazol-2-yl)benzamine Journal of Chemistry |
| title | Synthesis and Antimicrobial Activity of Some New Thiazolidin-4-one Derivatives of 4-(6-methylbenzo[d]thiazol-2-yl)benzamine |
| title_full | Synthesis and Antimicrobial Activity of Some New Thiazolidin-4-one Derivatives of 4-(6-methylbenzo[d]thiazol-2-yl)benzamine |
| title_fullStr | Synthesis and Antimicrobial Activity of Some New Thiazolidin-4-one Derivatives of 4-(6-methylbenzo[d]thiazol-2-yl)benzamine |
| title_full_unstemmed | Synthesis and Antimicrobial Activity of Some New Thiazolidin-4-one Derivatives of 4-(6-methylbenzo[d]thiazol-2-yl)benzamine |
| title_short | Synthesis and Antimicrobial Activity of Some New Thiazolidin-4-one Derivatives of 4-(6-methylbenzo[d]thiazol-2-yl)benzamine |
| title_sort | synthesis and antimicrobial activity of some new thiazolidin 4 one derivatives of 4 6 methylbenzo d thiazol 2 yl benzamine |
| url | http://dx.doi.org/10.1155/2013/185952 |
| work_keys_str_mv | AT awazjamilhussein synthesisandantimicrobialactivityofsomenewthiazolidin4onederivativesof46methylbenzodthiazol2ylbenzamine AT hashimjalalazeez synthesisandantimicrobialactivityofsomenewthiazolidin4onederivativesof46methylbenzodthiazol2ylbenzamine |