Dietary Ganglioside Reduces Proinflammatory Signaling in the Intestine
Gangliosides are integral to the structure and function of cell membranes. Ganglioside composition of the intestinal brush border and apical surface of the colon influences numerous cell processes including microbial attachment, cell division, differentiation, and signaling. Accelerated catabolism o...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2012/280286 |
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| author | John Janez Miklavcic Kareena Leanne Schnabl Vera Christine Mazurak Alan Bryan Robert Thomson Michael Thomas Clandinin |
| author_facet | John Janez Miklavcic Kareena Leanne Schnabl Vera Christine Mazurak Alan Bryan Robert Thomson Michael Thomas Clandinin |
| author_sort | John Janez Miklavcic |
| collection | DOAJ |
| description | Gangliosides are integral to the structure and function of cell membranes. Ganglioside composition of the intestinal brush border and apical surface of the colon influences numerous cell processes including microbial attachment, cell division, differentiation, and signaling. Accelerated catabolism of ganglioside in intestinal disease results in increased proinflammatory signaling. Restoring proper structure and function to the diseased intestine can resolve inflammation, increase resistance to infection, and improve gut integrity to induce remission of conditions like necrotizing enterocolitis (NEC) and Crohn's disease (CD). Maintaining inactive state of disease may be achieved by reducing the rate that gangliosides are degraded or by increasing intake of dietary ganglioside. Collectively, the studies outlined in this paper indicate that the amount of gangliosides GM3 and GD3 in intestinal mucosa is decreased with inflammation, low level of GM3 is associated with higher production of proinflammatory signals, and ganglioside content of intestinal mucosa can be increased by dietary ganglioside. |
| format | Article |
| id | doaj-art-fcf3f08dd1844ba9a5fdc20930037a5b |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-fcf3f08dd1844ba9a5fdc20930037a5b2025-02-03T01:10:44ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322012-01-01201210.1155/2012/280286280286Dietary Ganglioside Reduces Proinflammatory Signaling in the IntestineJohn Janez Miklavcic0Kareena Leanne Schnabl1Vera Christine Mazurak2Alan Bryan Robert Thomson3Michael Thomas Clandinin44-002 Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, AB, T6G 2R1, Canada200, 10150-102 street, Dyna LIFE Diagnostics, Edmonton, AB, T5J 5E2, Canada4-002 Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, AB, T6G 2R1, CanadaDivision of Gastroenterology, University of Western Ontario, London, ON, N6A 5A5, Canada4-002 Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, AB, T6G 2R1, CanadaGangliosides are integral to the structure and function of cell membranes. Ganglioside composition of the intestinal brush border and apical surface of the colon influences numerous cell processes including microbial attachment, cell division, differentiation, and signaling. Accelerated catabolism of ganglioside in intestinal disease results in increased proinflammatory signaling. Restoring proper structure and function to the diseased intestine can resolve inflammation, increase resistance to infection, and improve gut integrity to induce remission of conditions like necrotizing enterocolitis (NEC) and Crohn's disease (CD). Maintaining inactive state of disease may be achieved by reducing the rate that gangliosides are degraded or by increasing intake of dietary ganglioside. Collectively, the studies outlined in this paper indicate that the amount of gangliosides GM3 and GD3 in intestinal mucosa is decreased with inflammation, low level of GM3 is associated with higher production of proinflammatory signals, and ganglioside content of intestinal mucosa can be increased by dietary ganglioside.http://dx.doi.org/10.1155/2012/280286 |
| spellingShingle | John Janez Miklavcic Kareena Leanne Schnabl Vera Christine Mazurak Alan Bryan Robert Thomson Michael Thomas Clandinin Dietary Ganglioside Reduces Proinflammatory Signaling in the Intestine Journal of Nutrition and Metabolism |
| title | Dietary Ganglioside Reduces Proinflammatory Signaling in the Intestine |
| title_full | Dietary Ganglioside Reduces Proinflammatory Signaling in the Intestine |
| title_fullStr | Dietary Ganglioside Reduces Proinflammatory Signaling in the Intestine |
| title_full_unstemmed | Dietary Ganglioside Reduces Proinflammatory Signaling in the Intestine |
| title_short | Dietary Ganglioside Reduces Proinflammatory Signaling in the Intestine |
| title_sort | dietary ganglioside reduces proinflammatory signaling in the intestine |
| url | http://dx.doi.org/10.1155/2012/280286 |
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