Impact of osteoprotective therapies on the efficacy of immune checkpoint inhibition in melanoma patients – A multicentre study from the prospective skin cancer registry ADOReg

Impact of osteoprotective therapies on the efficacy of immune checkpoint inhibition in melanoma patients – A multicentre study from the prospective skin cancer registry ADOReg

Background: Osteoprotective therapy (OT), including denosumab and bisphosphonates, is approved as supportive treatment for patients with solid tumors to prevent skeletal-related events from bone metastases. Preclinical studies and clinical studies/series suggested a synergistic effect of OT and immu...

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Main Authors: Corinna Kochanek, Katrin Schaper-Gerhardt, Lisa Zimmer, Selma Ugurel, Friedegund Meier, Peter Mohr, Patrick Terheyden, Sebastian Haferkamp, Martin Kaatz, Michael Sachse, Frank Meiss, Claudia Pföhler, Ulrike Leiter, Jens Ulrich, Dirk Schadendorf, Michael Weichenthal, Imke von Wasielewski, Yenny Angela, Ralf Gutzmer
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:EJC Skin Cancer
Subjects:
Malignant melanoma
Immune checkpoint inhibition
Osteoprotective therapy
Denosumab
Bisphosphonates
Online Access:http://www.sciencedirect.com/science/article/pii/S2772611825004525
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