Cell surface Toll-like receptor polymorphisms influence Bartonella and ectoparasite infections in striped hamsters
Summary: This study explored how polymorphisms in cell surface Toll-like receptors (TLRs) influence susceptibility to Bartonella and ectoparasite infections in striped hamsters. Among six TLR genes, four sites in TLR1, TLR4, and TLR10 genes were associated with Bartonella susceptibility, while twelv...
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| Language: | English |
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Elsevier
2025-07-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225011447 |
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| author | Xinchang Lun Yujuan Yue Yiguan Wang Guichang Li Ning Zhao Fengxia Meng Qiyong Liu Pengbo Liu Zihao Wang Zhenxu Wang Xiuping Song Jun Wang Ying Liang Liang Lu |
| author_facet | Xinchang Lun Yujuan Yue Yiguan Wang Guichang Li Ning Zhao Fengxia Meng Qiyong Liu Pengbo Liu Zihao Wang Zhenxu Wang Xiuping Song Jun Wang Ying Liang Liang Lu |
| author_sort | Xinchang Lun |
| collection | DOAJ |
| description | Summary: This study explored how polymorphisms in cell surface Toll-like receptors (TLRs) influence susceptibility to Bartonella and ectoparasite infections in striped hamsters. Among six TLR genes, four sites in TLR1, TLR4, and TLR10 genes were associated with Bartonella susceptibility, while twelve sites across TLR4, TLR5, and TLR10 contributed to flea resistance. Similarly, eleven sites in TLR5, TLR6, and TLR10 were linked to gamasid mite parasitism. Genetic polymorphism analysis revealed that when heterozygous or rare genotypes protected the host from infections, the polymorphisms of these sites in uninfected individuals exceeded that of the infected group. The distribution of these sites on the three-dimensional structure of TLRs varied. All Bartonella-related sites were in the extracellular domain, whereas some of those related to fleas and gamasid mites were located in other domains. This research highlights the importance of cell surface TLRs in immune regulation and provides insights into evolutionary dynamics in natural environments. |
| format | Article |
| id | doaj-art-fcebd266ecfa48a9a03ba60e2ff88df2 |
| institution | OA Journals |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-fcebd266ecfa48a9a03ba60e2ff88df22025-08-20T02:35:00ZengElsevieriScience2589-00422025-07-0128711288310.1016/j.isci.2025.112883Cell surface Toll-like receptor polymorphisms influence Bartonella and ectoparasite infections in striped hamstersXinchang Lun0Yujuan Yue1Yiguan Wang2Guichang Li3Ning Zhao4Fengxia Meng5Qiyong Liu6Pengbo Liu7Zihao Wang8Zhenxu Wang9Xiuping Song10Jun Wang11Ying Liang12Liang Lu13National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaCAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; School of Public Health, Nanjing Medical University, Nanjing, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Corresponding authorSummary: This study explored how polymorphisms in cell surface Toll-like receptors (TLRs) influence susceptibility to Bartonella and ectoparasite infections in striped hamsters. Among six TLR genes, four sites in TLR1, TLR4, and TLR10 genes were associated with Bartonella susceptibility, while twelve sites across TLR4, TLR5, and TLR10 contributed to flea resistance. Similarly, eleven sites in TLR5, TLR6, and TLR10 were linked to gamasid mite parasitism. Genetic polymorphism analysis revealed that when heterozygous or rare genotypes protected the host from infections, the polymorphisms of these sites in uninfected individuals exceeded that of the infected group. The distribution of these sites on the three-dimensional structure of TLRs varied. All Bartonella-related sites were in the extracellular domain, whereas some of those related to fleas and gamasid mites were located in other domains. This research highlights the importance of cell surface TLRs in immune regulation and provides insights into evolutionary dynamics in natural environments.http://www.sciencedirect.com/science/article/pii/S2589004225011447MicrobiologyCell biology |
| spellingShingle | Xinchang Lun Yujuan Yue Yiguan Wang Guichang Li Ning Zhao Fengxia Meng Qiyong Liu Pengbo Liu Zihao Wang Zhenxu Wang Xiuping Song Jun Wang Ying Liang Liang Lu Cell surface Toll-like receptor polymorphisms influence Bartonella and ectoparasite infections in striped hamsters iScience Microbiology Cell biology |
| title | Cell surface Toll-like receptor polymorphisms influence Bartonella and ectoparasite infections in striped hamsters |
| title_full | Cell surface Toll-like receptor polymorphisms influence Bartonella and ectoparasite infections in striped hamsters |
| title_fullStr | Cell surface Toll-like receptor polymorphisms influence Bartonella and ectoparasite infections in striped hamsters |
| title_full_unstemmed | Cell surface Toll-like receptor polymorphisms influence Bartonella and ectoparasite infections in striped hamsters |
| title_short | Cell surface Toll-like receptor polymorphisms influence Bartonella and ectoparasite infections in striped hamsters |
| title_sort | cell surface toll like receptor polymorphisms influence bartonella and ectoparasite infections in striped hamsters |
| topic | Microbiology Cell biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225011447 |
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