Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis
The pathogenesis of acute exacerbation of idiopathic pulmonary fibrosis (IPF) remains to be elucidated. To evaluate the roles of inflammatory mediators in acute exacerbation, the concentrations of high mobility group protein B1 (HMGB1), a chief mediator of acute lung injury, and 18 inflammatory cyto...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/916486 |
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| author | Masahito Ebina Hiroyuki Taniguchi Taku Miyasho Shingo Yamada Naoko Shibata Hiromitsu Ohta Shu Hisata Shinya Ohkouchi Tsutomu Tamada Hidekazu Nishimura Akitoshi Ishizaka Ikuro Maruyama Yoshinori Okada Kondo Takashi Toshihiro Nukiwa |
| author_facet | Masahito Ebina Hiroyuki Taniguchi Taku Miyasho Shingo Yamada Naoko Shibata Hiromitsu Ohta Shu Hisata Shinya Ohkouchi Tsutomu Tamada Hidekazu Nishimura Akitoshi Ishizaka Ikuro Maruyama Yoshinori Okada Kondo Takashi Toshihiro Nukiwa |
| author_sort | Masahito Ebina |
| collection | DOAJ |
| description | The pathogenesis of acute exacerbation of idiopathic pulmonary fibrosis (IPF) remains to be elucidated. To evaluate the roles of inflammatory mediators in acute exacerbation, the concentrations of high mobility group protein B1 (HMGB1), a chief mediator of acute lung injury, and 18 inflammatory cytokines were measured in the bronchoalveolar lavage fluid, serially sampled from seven IPF patients after the onset of acute exacerbation. HMGB1 gradually increased in the alveolar fluid after the onset of acute exacerbation, in positive correlation with monocytes chemotactic protein-1 (MCP-1), a potent fibrogenic mediator. In the lung tissues of eight IPF patients autopsied after acute exacerbation, intense cytoplasmic staining for HMGB1 was observed in the alveolar epithelial cells in alveolar capillary augmented lesions, where the capillary endothelial cells remarkably reduced the expression of thrombomodulin, an intrinsic antagonist of HMGB1. These results suggest pathogenic roles for HMGB1 and MCP-1 in the late phase of acute exacerbation of IPF. |
| format | Article |
| id | doaj-art-fce6f359a2074833a45ff66deda7e1f4 |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-fce6f359a2074833a45ff66deda7e1f42025-02-03T05:52:34ZengWileyPulmonary Medicine2090-18362090-18442011-01-01201110.1155/2011/916486916486Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary FibrosisMasahito Ebina0Hiroyuki Taniguchi1Taku Miyasho2Shingo Yamada3Naoko Shibata4Hiromitsu Ohta5Shu Hisata6Shinya Ohkouchi7Tsutomu Tamada8Hidekazu Nishimura9Akitoshi Ishizaka10Ikuro Maruyama11Yoshinori Okada12Kondo Takashi13Toshihiro Nukiwa14Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba-ku, Sendai 980-8574, JapanDepartment of Respiratory Medicine, Tosei General Hospital, Seto, Aichi 489-8642, JapanDepartment of Veterinary Biochemistry, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, JapanCentral Institute, Shino-Test Corporation, Kanagawa 229-0011, JapanDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba-ku, Sendai 980-8574, JapanDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba-ku, Sendai 980-8574, JapanDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba-ku, Sendai 980-8574, JapanDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba-ku, Sendai 980-8574, JapanDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba-ku, Sendai 980-8574, JapanVirus Research Center, National Hospital Organization, Sendai 983-0045, JapanDepartment of Medicine, Keio University, Tokyo 160-8582, JapanDepartment of Laboratory and Molecular Medicine, Kagoshima University, Kagoshima 890-8520, JapanDepartment of Thoracic Surgery, Tohoku University Hospital, Sendai 980-8574, JapanDepartment of Thoracic Surgery, Tohoku University Hospital, Sendai 980-8574, JapanDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba-ku, Sendai 980-8574, JapanThe pathogenesis of acute exacerbation of idiopathic pulmonary fibrosis (IPF) remains to be elucidated. To evaluate the roles of inflammatory mediators in acute exacerbation, the concentrations of high mobility group protein B1 (HMGB1), a chief mediator of acute lung injury, and 18 inflammatory cytokines were measured in the bronchoalveolar lavage fluid, serially sampled from seven IPF patients after the onset of acute exacerbation. HMGB1 gradually increased in the alveolar fluid after the onset of acute exacerbation, in positive correlation with monocytes chemotactic protein-1 (MCP-1), a potent fibrogenic mediator. In the lung tissues of eight IPF patients autopsied after acute exacerbation, intense cytoplasmic staining for HMGB1 was observed in the alveolar epithelial cells in alveolar capillary augmented lesions, where the capillary endothelial cells remarkably reduced the expression of thrombomodulin, an intrinsic antagonist of HMGB1. These results suggest pathogenic roles for HMGB1 and MCP-1 in the late phase of acute exacerbation of IPF.http://dx.doi.org/10.1155/2011/916486 |
| spellingShingle | Masahito Ebina Hiroyuki Taniguchi Taku Miyasho Shingo Yamada Naoko Shibata Hiromitsu Ohta Shu Hisata Shinya Ohkouchi Tsutomu Tamada Hidekazu Nishimura Akitoshi Ishizaka Ikuro Maruyama Yoshinori Okada Kondo Takashi Toshihiro Nukiwa Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis Pulmonary Medicine |
| title | Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
| title_full | Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
| title_fullStr | Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
| title_full_unstemmed | Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
| title_short | Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis |
| title_sort | gradual increase of high mobility group protein b1 in the lungs after the onset of acute exacerbation of idiopathic pulmonary fibrosis |
| url | http://dx.doi.org/10.1155/2011/916486 |
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