3D-Printed Plasmonic Nanocomposites: VAT Photopolymerization for Photothermal-Controlled Drug Release
Background: Gold nanoparticles can generate heat upon exposure to radiation due to their plasmonic properties, which depend on particle size and shape. This enables precise control over the release of active substances from polymeric pharmaceutical formulations, minimizing side effects and premature...
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MDPI AG
2024-10-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/17/11/1453 |
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| author | Ignacia Paz Torres Fredes Elizabeth Nicole Cortés-Adasme Bruno Andrés Barrientos Juan Pablo Real Cesar Gerardo Gomez Santiago Daniel Palma Marcelo Javier Kogan Daniel Andrés Real |
| author_facet | Ignacia Paz Torres Fredes Elizabeth Nicole Cortés-Adasme Bruno Andrés Barrientos Juan Pablo Real Cesar Gerardo Gomez Santiago Daniel Palma Marcelo Javier Kogan Daniel Andrés Real |
| author_sort | Ignacia Paz Torres Fredes |
| collection | DOAJ |
| description | Background: Gold nanoparticles can generate heat upon exposure to radiation due to their plasmonic properties, which depend on particle size and shape. This enables precise control over the release of active substances from polymeric pharmaceutical formulations, minimizing side effects and premature release. The technology of 3D printing, especially vat photopolymerization, is valuable for integrating nanoparticles into complex formulations. Method: This study aimed to incorporate gold nanospheres (AuNSs) and nanorods (AuNRs) into polymeric matrices using vat photopolymerization, allowing for controlled drug release with exposure to 532 nm and 1064 nm wavelengths. Results: The AuNSs (27 nm) responded to 532 nm and the NRs (60 nm length, 10 nm width) responded to 1064 nm. Niclosamide was used as the drug model. Ternary blends of Polyethylene Glycol Diacrylate 250 (PEGDA 250), Polyethylene Glycol 400 (PEG 400), and water were optimized using DesignExpert 11 software for controlled drug release upon specific wavelength exposure. Three matrices, selected based on solubility and printability, underwent rigorous characterization. Two materials achieved controlled drug release with specific wavelengths. Bilayer devices combining AuNSs and AuNRs demonstrated selective drug release based on irradiation wavelength. Conclusions: A pharmaceutical device was developed, capable of controlling drug release upon irradiation, with potential applications in treatments requiring delayed administration. |
| format | Article |
| id | doaj-art-fce52efa86ee4108955257d226dea493 |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-fce52efa86ee4108955257d226dea4932024-11-26T18:17:13ZengMDPI AGPharmaceuticals1424-82472024-10-011711145310.3390/ph171114533D-Printed Plasmonic Nanocomposites: VAT Photopolymerization for Photothermal-Controlled Drug ReleaseIgnacia Paz Torres Fredes0Elizabeth Nicole Cortés-Adasme1Bruno Andrés Barrientos2Juan Pablo Real3Cesar Gerardo Gomez4Santiago Daniel Palma5Marcelo Javier Kogan6Daniel Andrés Real7Department of Pharmacological and Toxicological Chemistry, University of Chile, Santos Dumont 964, Santiago 8380494, ChileDepartment of Pharmacological and Toxicological Chemistry, University of Chile, Santos Dumont 964, Santiago 8380494, ChileUnidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA-CONICET), Haya de la Torre y Medina Allende, Córdoba X5000XHUA, ArgentinaUnidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA-CONICET), Haya de la Torre y Medina Allende, Córdoba X5000XHUA, ArgentinaDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba X5000XHUA, ArgentinaUnidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA-CONICET), Haya de la Torre y Medina Allende, Córdoba X5000XHUA, ArgentinaDepartment of Pharmacological and Toxicological Chemistry, University of Chile, Santos Dumont 964, Santiago 8380494, ChileDepartment of Pharmacological and Toxicological Chemistry, University of Chile, Santos Dumont 964, Santiago 8380494, ChileBackground: Gold nanoparticles can generate heat upon exposure to radiation due to their plasmonic properties, which depend on particle size and shape. This enables precise control over the release of active substances from polymeric pharmaceutical formulations, minimizing side effects and premature release. The technology of 3D printing, especially vat photopolymerization, is valuable for integrating nanoparticles into complex formulations. Method: This study aimed to incorporate gold nanospheres (AuNSs) and nanorods (AuNRs) into polymeric matrices using vat photopolymerization, allowing for controlled drug release with exposure to 532 nm and 1064 nm wavelengths. Results: The AuNSs (27 nm) responded to 532 nm and the NRs (60 nm length, 10 nm width) responded to 1064 nm. Niclosamide was used as the drug model. Ternary blends of Polyethylene Glycol Diacrylate 250 (PEGDA 250), Polyethylene Glycol 400 (PEG 400), and water were optimized using DesignExpert 11 software for controlled drug release upon specific wavelength exposure. Three matrices, selected based on solubility and printability, underwent rigorous characterization. Two materials achieved controlled drug release with specific wavelengths. Bilayer devices combining AuNSs and AuNRs demonstrated selective drug release based on irradiation wavelength. Conclusions: A pharmaceutical device was developed, capable of controlling drug release upon irradiation, with potential applications in treatments requiring delayed administration.https://www.mdpi.com/1424-8247/17/11/14533D printingcontrolled drug releasephotothermal drug deliveryniclosamidevat photopolymerization |
| spellingShingle | Ignacia Paz Torres Fredes Elizabeth Nicole Cortés-Adasme Bruno Andrés Barrientos Juan Pablo Real Cesar Gerardo Gomez Santiago Daniel Palma Marcelo Javier Kogan Daniel Andrés Real 3D-Printed Plasmonic Nanocomposites: VAT Photopolymerization for Photothermal-Controlled Drug Release Pharmaceuticals 3D printing controlled drug release photothermal drug delivery niclosamide vat photopolymerization |
| title | 3D-Printed Plasmonic Nanocomposites: VAT Photopolymerization for Photothermal-Controlled Drug Release |
| title_full | 3D-Printed Plasmonic Nanocomposites: VAT Photopolymerization for Photothermal-Controlled Drug Release |
| title_fullStr | 3D-Printed Plasmonic Nanocomposites: VAT Photopolymerization for Photothermal-Controlled Drug Release |
| title_full_unstemmed | 3D-Printed Plasmonic Nanocomposites: VAT Photopolymerization for Photothermal-Controlled Drug Release |
| title_short | 3D-Printed Plasmonic Nanocomposites: VAT Photopolymerization for Photothermal-Controlled Drug Release |
| title_sort | 3d printed plasmonic nanocomposites vat photopolymerization for photothermal controlled drug release |
| topic | 3D printing controlled drug release photothermal drug delivery niclosamide vat photopolymerization |
| url | https://www.mdpi.com/1424-8247/17/11/1453 |
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