Distinct microRNA signatures define sporadic PSP-RS and PD in patient-derived midbrain organoids

Distinct microRNA signatures define sporadic PSP-RS and PD in patient-derived midbrain organoids

Summary: Progressive supranuclear Palsy–Richardson syndrome (PSP-RS) is a rare, rapidly progressive tauopathy often misdiagnosed as Parkinson’s disease (PD) due to overlapping clinical features and the lack of reliable molecular biomarkers. To address this need, we generated human midbrain organoids...

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Main Authors: Desirèe Valente, Clara Zannino, Stefania Scalise, Davide Bressan, Valeria Lucchino, Ermes Filomena, Giorgia Lucia Benedetto, Ida Lazzinnaro, Mariagrazia Talarico, Andrea Quattrone, Fulvio Chiacchiera, Graziano Pesole, Aldo Quattrone, Elvira Immacolata Parrotta, Giovanni Cuda
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Neuroscience
Cellular neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225014233
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