Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice.
The flavonoids mosloflavone, oroxylin A, and norwogonin, which were purified from Scutellaria baicalensis Georgi, significantly protected Vero cells against Coxsackievirus B3 (CVB3)-induced cell death. To investigate the in vivo antiviral activity of oroxylin A, we intraperitoneally inoculated CVB3...
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155784&type=printable |
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| author | Bo-Eun Kwon Jae-Hyoung Song Hyuk-Hwan Song Ju Won Kang Sam Noh Hwang Ki-Jong Rhee Aeri Shim Eun-Hye Hong Yeon-Jeong Kim Sang-Min Jeon Sun-Young Chang Dong-Eun Kim Sungchan Cho Hyun-Jeong Ko |
| author_facet | Bo-Eun Kwon Jae-Hyoung Song Hyuk-Hwan Song Ju Won Kang Sam Noh Hwang Ki-Jong Rhee Aeri Shim Eun-Hye Hong Yeon-Jeong Kim Sang-Min Jeon Sun-Young Chang Dong-Eun Kim Sungchan Cho Hyun-Jeong Ko |
| author_sort | Bo-Eun Kwon |
| collection | DOAJ |
| description | The flavonoids mosloflavone, oroxylin A, and norwogonin, which were purified from Scutellaria baicalensis Georgi, significantly protected Vero cells against Coxsackievirus B3 (CVB3)-induced cell death. To investigate the in vivo antiviral activity of oroxylin A, we intraperitoneally inoculated CVB3 into 4-week-old BALB/c mice. Body weights and blood glucose levels of the mice were decreased after CVB3 infection, and these changes were attenuated by the administration of oroxylin A. Importantly, treatment of mice with oroxylin A reduced viral titers in the pancreas and decreased the serum levels of the inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α. Additionally, the administration of oroxylin A mitigated the histological pancreatic lesions and apoptotic cell death induced by CVB3 infection and increased the levels of phospho-eIF2α in infected pancreata. The results suggest that oroxylin A may represent a potent antiviral agent against CVB3 infection. |
| format | Article |
| id | doaj-art-fccb7efefb8a4b63a099f89c87c96808 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-fccb7efefb8a4b63a099f89c87c968082025-08-20T02:15:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01115e015578410.1371/journal.pone.0155784Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice.Bo-Eun KwonJae-Hyoung SongHyuk-Hwan SongJu Won KangSam Noh HwangKi-Jong RheeAeri ShimEun-Hye HongYeon-Jeong KimSang-Min JeonSun-Young ChangDong-Eun KimSungchan ChoHyun-Jeong KoThe flavonoids mosloflavone, oroxylin A, and norwogonin, which were purified from Scutellaria baicalensis Georgi, significantly protected Vero cells against Coxsackievirus B3 (CVB3)-induced cell death. To investigate the in vivo antiviral activity of oroxylin A, we intraperitoneally inoculated CVB3 into 4-week-old BALB/c mice. Body weights and blood glucose levels of the mice were decreased after CVB3 infection, and these changes were attenuated by the administration of oroxylin A. Importantly, treatment of mice with oroxylin A reduced viral titers in the pancreas and decreased the serum levels of the inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α. Additionally, the administration of oroxylin A mitigated the histological pancreatic lesions and apoptotic cell death induced by CVB3 infection and increased the levels of phospho-eIF2α in infected pancreata. The results suggest that oroxylin A may represent a potent antiviral agent against CVB3 infection.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155784&type=printable |
| spellingShingle | Bo-Eun Kwon Jae-Hyoung Song Hyuk-Hwan Song Ju Won Kang Sam Noh Hwang Ki-Jong Rhee Aeri Shim Eun-Hye Hong Yeon-Jeong Kim Sang-Min Jeon Sun-Young Chang Dong-Eun Kim Sungchan Cho Hyun-Jeong Ko Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice. PLoS ONE |
| title | Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice. |
| title_full | Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice. |
| title_fullStr | Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice. |
| title_full_unstemmed | Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice. |
| title_short | Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice. |
| title_sort | antiviral activity of oroxylin a against coxsackievirus b3 alleviates virus induced acute pancreatic damage in mice |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155784&type=printable |
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