Serum level of soluble interleukin‐2 receptor is positively correlated with metabolic tumor volume on 18F‐FDG PET/CT in newly diagnosed patients with diffuse large B‐cell lymphoma
Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most frequent subtype of non‐Hodgkin lymphoma. High total metabolic tumor volume (TMTV) calculated using 18F‐FDG PET/CT images at diagnosis predicts poor prognosis of patients with DLBCL. However, high cost and poor access to the imaging faciliti...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-03-01
|
| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.1973 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832576242631573504 |
|---|---|
| author | Hajime Senjo Minoru Kanaya Koh Izumiyama Koichiro Minauchi Kenji Hirata Akio Mori Makoto Saito Masanori Tanaka Hiroaki Iijima Eriko Tsukamoto Kazuo Itoh Shuichi Ota Masanobu Morioka Daigo Hashimoto Takanori Teshima North Japan Hematology Study Group (NJHSG) |
| author_facet | Hajime Senjo Minoru Kanaya Koh Izumiyama Koichiro Minauchi Kenji Hirata Akio Mori Makoto Saito Masanori Tanaka Hiroaki Iijima Eriko Tsukamoto Kazuo Itoh Shuichi Ota Masanobu Morioka Daigo Hashimoto Takanori Teshima North Japan Hematology Study Group (NJHSG) |
| author_sort | Hajime Senjo |
| collection | DOAJ |
| description | Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most frequent subtype of non‐Hodgkin lymphoma. High total metabolic tumor volume (TMTV) calculated using 18F‐FDG PET/CT images at diagnosis predicts poor prognosis of patients with DLBCL. However, high cost and poor access to the imaging facilities hamper wider use of 18F‐FDG PET/CT. In order to explore a surrogate marker for TMTV, we evaluated the correlation between the serum levels of soluble interleukin‐2 receptor (sIL‐2R) and TMTV in 64 patients with DLBCL, and the results were verified in an independent validation cohort of 86 patients. Serum levels of sIL‐2R were significantly correlated with TMTV. ROC analysis revealed that the cutoff value of TMTV ≥150 cm3 or sIL‐2R ≥ 1300 U/mL could predict failure to achieve EFS24 with areas under the curve (AUC) 0.706 and 0.758, respectively. Each of TMTV ≥150 cm3 and sIL‐2R ≥1300 U/mL was significantly associated with worse 5‐year overall survival and event‐free survival. Importantly, each of sIL‐2R <1300 U/mL or TMTV <150 cm3 identified patients with favorable prognosis among NCCN‐IPI high‐intermediate and high‐risk group. Serum level of sIL‐2R represents a convenient surrogate marker to estimate metabolic tumor burden measured by 18F‐FDG PET/CT that can predict treatment outcomes of patients with DLBCL. |
| format | Article |
| id | doaj-art-fcc72633f7674267b1aec30212444942 |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2019-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-fcc72633f7674267b1aec302124449422025-01-31T08:47:42ZengWileyCancer Medicine2045-76342019-03-018395396210.1002/cam4.1973Serum level of soluble interleukin‐2 receptor is positively correlated with metabolic tumor volume on 18F‐FDG PET/CT in newly diagnosed patients with diffuse large B‐cell lymphomaHajime Senjo0Minoru Kanaya1Koh Izumiyama2Koichiro Minauchi3Kenji Hirata4Akio Mori5Makoto Saito6Masanori Tanaka7Hiroaki Iijima8Eriko Tsukamoto9Kazuo Itoh10Shuichi Ota11Masanobu Morioka12Daigo Hashimoto13Takanori Teshima14North Japan Hematology Study Group (NJHSG)Department of Hematology Aiiku Hospital Sapporo JapanDepartment of Hematology Aiiku Hospital Sapporo JapanDepartment of Hematology Aiiku Hospital Sapporo JapanDepartment of Hematology Sapporo Hokuyu Hospital Sapporo JapanDepartment of Nuclear Medicine, Graduate School of Medicine Hokkaido University Sapporo JapanDepartment of Hematology Aiiku Hospital Sapporo JapanDepartment of Hematology Aiiku Hospital Sapporo JapanDepartment of Hematology Aiiku Hospital Sapporo JapanClinical Research and Medical Innovation Center Hokkaido University Hospital Sapporo JapanDepartment of Radiology Central CI Clinic Sapporo JapanDepartment of Radiology Keiyukai Sapporo Hospital Sapporo JapanDepartment of Hematology Sapporo Hokuyu Hospital Sapporo JapanDepartment of Hematology Aiiku Hospital Sapporo JapanDepartment of Hematology, Faculty of Medicine Hokkaido University Sapporo JapanDepartment of Hematology, Faculty of Medicine Hokkaido University Sapporo JapanAbstract Diffuse large B‐cell lymphoma (DLBCL) is the most frequent subtype of non‐Hodgkin lymphoma. High total metabolic tumor volume (TMTV) calculated using 18F‐FDG PET/CT images at diagnosis predicts poor prognosis of patients with DLBCL. However, high cost and poor access to the imaging facilities hamper wider use of 18F‐FDG PET/CT. In order to explore a surrogate marker for TMTV, we evaluated the correlation between the serum levels of soluble interleukin‐2 receptor (sIL‐2R) and TMTV in 64 patients with DLBCL, and the results were verified in an independent validation cohort of 86 patients. Serum levels of sIL‐2R were significantly correlated with TMTV. ROC analysis revealed that the cutoff value of TMTV ≥150 cm3 or sIL‐2R ≥ 1300 U/mL could predict failure to achieve EFS24 with areas under the curve (AUC) 0.706 and 0.758, respectively. Each of TMTV ≥150 cm3 and sIL‐2R ≥1300 U/mL was significantly associated with worse 5‐year overall survival and event‐free survival. Importantly, each of sIL‐2R <1300 U/mL or TMTV <150 cm3 identified patients with favorable prognosis among NCCN‐IPI high‐intermediate and high‐risk group. Serum level of sIL‐2R represents a convenient surrogate marker to estimate metabolic tumor burden measured by 18F‐FDG PET/CT that can predict treatment outcomes of patients with DLBCL.https://doi.org/10.1002/cam4.1973diffuse large B‐cell lymphomasoluble interleukin‐2 receptortotal metabolic tumor volume |
| spellingShingle | Hajime Senjo Minoru Kanaya Koh Izumiyama Koichiro Minauchi Kenji Hirata Akio Mori Makoto Saito Masanori Tanaka Hiroaki Iijima Eriko Tsukamoto Kazuo Itoh Shuichi Ota Masanobu Morioka Daigo Hashimoto Takanori Teshima North Japan Hematology Study Group (NJHSG) Serum level of soluble interleukin‐2 receptor is positively correlated with metabolic tumor volume on 18F‐FDG PET/CT in newly diagnosed patients with diffuse large B‐cell lymphoma Cancer Medicine diffuse large B‐cell lymphoma soluble interleukin‐2 receptor total metabolic tumor volume |
| title | Serum level of soluble interleukin‐2 receptor is positively correlated with metabolic tumor volume on 18F‐FDG PET/CT in newly diagnosed patients with diffuse large B‐cell lymphoma |
| title_full | Serum level of soluble interleukin‐2 receptor is positively correlated with metabolic tumor volume on 18F‐FDG PET/CT in newly diagnosed patients with diffuse large B‐cell lymphoma |
| title_fullStr | Serum level of soluble interleukin‐2 receptor is positively correlated with metabolic tumor volume on 18F‐FDG PET/CT in newly diagnosed patients with diffuse large B‐cell lymphoma |
| title_full_unstemmed | Serum level of soluble interleukin‐2 receptor is positively correlated with metabolic tumor volume on 18F‐FDG PET/CT in newly diagnosed patients with diffuse large B‐cell lymphoma |
| title_short | Serum level of soluble interleukin‐2 receptor is positively correlated with metabolic tumor volume on 18F‐FDG PET/CT in newly diagnosed patients with diffuse large B‐cell lymphoma |
| title_sort | serum level of soluble interleukin 2 receptor is positively correlated with metabolic tumor volume on 18f fdg pet ct in newly diagnosed patients with diffuse large b cell lymphoma |
| topic | diffuse large B‐cell lymphoma soluble interleukin‐2 receptor total metabolic tumor volume |
| url | https://doi.org/10.1002/cam4.1973 |
| work_keys_str_mv | AT hajimesenjo serumlevelofsolubleinterleukin2receptorispositivelycorrelatedwithmetabolictumorvolumeon18ffdgpetctinnewlydiagnosedpatientswithdiffuselargebcelllymphoma AT minorukanaya serumlevelofsolubleinterleukin2receptorispositivelycorrelatedwithmetabolictumorvolumeon18ffdgpetctinnewlydiagnosedpatientswithdiffuselargebcelllymphoma AT kohizumiyama serumlevelofsolubleinterleukin2receptorispositivelycorrelatedwithmetabolictumorvolumeon18ffdgpetctinnewlydiagnosedpatientswithdiffuselargebcelllymphoma AT koichirominauchi serumlevelofsolubleinterleukin2receptorispositivelycorrelatedwithmetabolictumorvolumeon18ffdgpetctinnewlydiagnosedpatientswithdiffuselargebcelllymphoma AT kenjihirata serumlevelofsolubleinterleukin2receptorispositivelycorrelatedwithmetabolictumorvolumeon18ffdgpetctinnewlydiagnosedpatientswithdiffuselargebcelllymphoma AT akiomori serumlevelofsolubleinterleukin2receptorispositivelycorrelatedwithmetabolictumorvolumeon18ffdgpetctinnewlydiagnosedpatientswithdiffuselargebcelllymphoma AT makotosaito serumlevelofsolubleinterleukin2receptorispositivelycorrelatedwithmetabolictumorvolumeon18ffdgpetctinnewlydiagnosedpatientswithdiffuselargebcelllymphoma AT masanoritanaka serumlevelofsolubleinterleukin2receptorispositivelycorrelatedwithmetabolictumorvolumeon18ffdgpetctinnewlydiagnosedpatientswithdiffuselargebcelllymphoma AT hiroakiiijima serumlevelofsolubleinterleukin2receptorispositivelycorrelatedwithmetabolictumorvolumeon18ffdgpetctinnewlydiagnosedpatientswithdiffuselargebcelllymphoma AT erikotsukamoto serumlevelofsolubleinterleukin2receptorispositivelycorrelatedwithmetabolictumorvolumeon18ffdgpetctinnewlydiagnosedpatientswithdiffuselargebcelllymphoma AT kazuoitoh serumlevelofsolubleinterleukin2receptorispositivelycorrelatedwithmetabolictumorvolumeon18ffdgpetctinnewlydiagnosedpatientswithdiffuselargebcelllymphoma AT shuichiota serumlevelofsolubleinterleukin2receptorispositivelycorrelatedwithmetabolictumorvolumeon18ffdgpetctinnewlydiagnosedpatientswithdiffuselargebcelllymphoma AT masanobumorioka serumlevelofsolubleinterleukin2receptorispositivelycorrelatedwithmetabolictumorvolumeon18ffdgpetctinnewlydiagnosedpatientswithdiffuselargebcelllymphoma AT daigohashimoto serumlevelofsolubleinterleukin2receptorispositivelycorrelatedwithmetabolictumorvolumeon18ffdgpetctinnewlydiagnosedpatientswithdiffuselargebcelllymphoma AT takanoriteshima serumlevelofsolubleinterleukin2receptorispositivelycorrelatedwithmetabolictumorvolumeon18ffdgpetctinnewlydiagnosedpatientswithdiffuselargebcelllymphoma AT northjapanhematologystudygroupnjhsg serumlevelofsolubleinterleukin2receptorispositivelycorrelatedwithmetabolictumorvolumeon18ffdgpetctinnewlydiagnosedpatientswithdiffuselargebcelllymphoma |