Bioelectric stimulation outperforms brain derived neurotrophic factor in promoting neuronal maturation

Bioelectric stimulation outperforms brain derived neurotrophic factor in promoting neuronal maturation

Abstract Neuronal differentiation and maturation are crucial for developing research models and therapeutic applications. Brain-derived neurotrophic factor (BDNF) is a widely used biochemical stimulus for promoting neuronal maturation. However, the broad effects of biochemical stimuli on multiple ce...

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Bibliographic Details
Main Authors: María del Pilar Diego-Santiago, María Ujué González, Esther María Zamora Sánchez, Nuria Cortes-Carrillo, Carlos Dotti, Francesc Xavier Guix, Sahba Mobini
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Neuronal differentiation and maturation
Electrical stimulation
Charge injection
Biochemical-free stimulation
Neural extracellular vesicles
Online Access:https://doi.org/10.1038/s41598-025-89330-4
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