High-intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosis
Background: The increasing prevalence of acute noise exposure poses a significant threat to mental health. Identifying the intensity of noise that impair health is crucial for developing effective interventions. The study aimed to determine the acute noise intensity thresholds that elicit anxiety-li...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325001691 |
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| author | Yifei Song Xiaoni Wang Haoyu Zhang Rui Ma Yiting Kang Xiaohui Di Zeguo Feng Can Ni Fadong Zhao Hongwei Zhuang Jianbao Zhang |
| author_facet | Yifei Song Xiaoni Wang Haoyu Zhang Rui Ma Yiting Kang Xiaohui Di Zeguo Feng Can Ni Fadong Zhao Hongwei Zhuang Jianbao Zhang |
| author_sort | Yifei Song |
| collection | DOAJ |
| description | Background: The increasing prevalence of acute noise exposure poses a significant threat to mental health. Identifying the intensity of noise that impair health is crucial for developing effective interventions. The study aimed to determine the acute noise intensity thresholds that elicit anxiety-like behaviors and brain damage in female rats, and then to elucidate the underlying neurobiological mechanisms. Methods: Female rats were subjected to acute noise exposure at levels of 105, 115, 125, and 135 dB to determine the intensity thresholds that elicit anxiety-like behaviors and brain damage were assessed at the 3th day and 1 month post-exposure. Results: We found that acute noise exposure at 135 dB induced significant anxiety-like behaviors and hippocampal neuron apoptosis on the third day, with these effects persisting up to one month after exposure. KEGG enrichment analysis of differentially expressed genes (DEGs) revealed alterations in the PI3K-AKT signaling pathway, as confirmed by Western blot analysis. Conclusions: Our findings indicate that acute noise exposure at 135 dB elicits anxiety-like behaviors in female rats on the third day post-exposure, with these effects persisting up to one month. This sustained anxiety is attributed to the inhibition of the PI3K-AKT signaling pathway and the subsequent activation of the apoptotic Caspase-3/BCL-2/BAX pathway, culminating in hippocampal neuron apoptosis. |
| format | Article |
| id | doaj-art-fcabc72eb4a745289be6d4a347cb36b9 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-fcabc72eb4a745289be6d4a347cb36b92025-02-05T04:31:04ZengElsevierEcotoxicology and Environmental Safety0147-65132025-02-01291117833High-intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosisYifei Song0Xiaoni Wang1Haoyu Zhang2Rui Ma3Yiting Kang4Xiaohui Di5Zeguo Feng6Can Ni7Fadong Zhao8Hongwei Zhuang9Jianbao Zhang10Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, ChinaKey Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, ChinaKey Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, ChinaKey Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, ChinaKey Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, ChinaKey Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, ChinaKey Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, ChinaKey Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, ChinaKey Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China; Equipment Management and Support College, Chinese People's Armed Police Force Engineering University, Xi'an, ChinaEquipment Management and Support College, Chinese People's Armed Police Force Engineering University, Xi'an, ChinaKey Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China; Corresponding author.Background: The increasing prevalence of acute noise exposure poses a significant threat to mental health. Identifying the intensity of noise that impair health is crucial for developing effective interventions. The study aimed to determine the acute noise intensity thresholds that elicit anxiety-like behaviors and brain damage in female rats, and then to elucidate the underlying neurobiological mechanisms. Methods: Female rats were subjected to acute noise exposure at levels of 105, 115, 125, and 135 dB to determine the intensity thresholds that elicit anxiety-like behaviors and brain damage were assessed at the 3th day and 1 month post-exposure. Results: We found that acute noise exposure at 135 dB induced significant anxiety-like behaviors and hippocampal neuron apoptosis on the third day, with these effects persisting up to one month after exposure. KEGG enrichment analysis of differentially expressed genes (DEGs) revealed alterations in the PI3K-AKT signaling pathway, as confirmed by Western blot analysis. Conclusions: Our findings indicate that acute noise exposure at 135 dB elicits anxiety-like behaviors in female rats on the third day post-exposure, with these effects persisting up to one month. This sustained anxiety is attributed to the inhibition of the PI3K-AKT signaling pathway and the subsequent activation of the apoptotic Caspase-3/BCL-2/BAX pathway, culminating in hippocampal neuron apoptosis.http://www.sciencedirect.com/science/article/pii/S0147651325001691Acute noiseAnxietyHippocampusPI3K-AKT signaling pathwayApoptosis |
| spellingShingle | Yifei Song Xiaoni Wang Haoyu Zhang Rui Ma Yiting Kang Xiaohui Di Zeguo Feng Can Ni Fadong Zhao Hongwei Zhuang Jianbao Zhang High-intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosis Ecotoxicology and Environmental Safety Acute noise Anxiety Hippocampus PI3K-AKT signaling pathway Apoptosis |
| title | High-intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosis |
| title_full | High-intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosis |
| title_fullStr | High-intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosis |
| title_full_unstemmed | High-intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosis |
| title_short | High-intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosis |
| title_sort | high intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosis |
| topic | Acute noise Anxiety Hippocampus PI3K-AKT signaling pathway Apoptosis |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325001691 |
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