Hypervalent iodine-mediated intramolecular alkene halocyclisation
The chemistry of hypervalent iodine (HVI) reagents has gathered increased attention towards the synthesis of a wide range of chemical structures. HVI reagents are characterized by their diverse reactivity as oxidants and electrophilic reagents. In addition, they are inexpensive, non-toxic and consid...
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2024-11-01
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| Series: | Beilstein Journal of Organic Chemistry |
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| Online Access: | https://doi.org/10.3762/bjoc.20.258 |
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| author | Charu Bansal Oliver Ruggles Albert C. Rowett Alastair J. J. Lennox |
| author_facet | Charu Bansal Oliver Ruggles Albert C. Rowett Alastair J. J. Lennox |
| author_sort | Charu Bansal |
| collection | DOAJ |
| description | The chemistry of hypervalent iodine (HVI) reagents has gathered increased attention towards the synthesis of a wide range of chemical structures. HVI reagents are characterized by their diverse reactivity as oxidants and electrophilic reagents. In addition, they are inexpensive, non-toxic and considered to be environmentally friendly. An important application of HVI reagents is the synthesis of halogenated cyclic compounds, in particular, the intramolecular HVI-mediated halocyclisation of alkenes using carbon, oxygen, nitrogen or sulfur nucleophiles. Herein, we describe the examples reported in the literature, which are organised by the different halogens involved and the internal nucleophiles. |
| format | Article |
| id | doaj-art-fca86d2d2dfa4b709da3c53ff80c24d4 |
| institution | OA Journals |
| issn | 1860-5397 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj-art-fca86d2d2dfa4b709da3c53ff80c24d42025-08-20T02:18:24ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972024-11-012013113313310.3762/bjoc.20.2581860-5397-20-258Hypervalent iodine-mediated intramolecular alkene halocyclisationCharu Bansal0Oliver Ruggles1Albert C. Rowett2Alastair J. J. Lennox3University of Bristol, School of Chemistry, Bristol, BS8 1TS, UK University of Bristol, School of Chemistry, Bristol, BS8 1TS, UK University of Bristol, School of Chemistry, Bristol, BS8 1TS, UK University of Bristol, School of Chemistry, Bristol, BS8 1TS, UK The chemistry of hypervalent iodine (HVI) reagents has gathered increased attention towards the synthesis of a wide range of chemical structures. HVI reagents are characterized by their diverse reactivity as oxidants and electrophilic reagents. In addition, they are inexpensive, non-toxic and considered to be environmentally friendly. An important application of HVI reagents is the synthesis of halogenated cyclic compounds, in particular, the intramolecular HVI-mediated halocyclisation of alkenes using carbon, oxygen, nitrogen or sulfur nucleophiles. Herein, we describe the examples reported in the literature, which are organised by the different halogens involved and the internal nucleophiles.https://doi.org/10.3762/bjoc.20.258cyclisationhalogenationheterocycleshypervalent iodineoxidation |
| spellingShingle | Charu Bansal Oliver Ruggles Albert C. Rowett Alastair J. J. Lennox Hypervalent iodine-mediated intramolecular alkene halocyclisation Beilstein Journal of Organic Chemistry cyclisation halogenation heterocycles hypervalent iodine oxidation |
| title | Hypervalent iodine-mediated intramolecular alkene halocyclisation |
| title_full | Hypervalent iodine-mediated intramolecular alkene halocyclisation |
| title_fullStr | Hypervalent iodine-mediated intramolecular alkene halocyclisation |
| title_full_unstemmed | Hypervalent iodine-mediated intramolecular alkene halocyclisation |
| title_short | Hypervalent iodine-mediated intramolecular alkene halocyclisation |
| title_sort | hypervalent iodine mediated intramolecular alkene halocyclisation |
| topic | cyclisation halogenation heterocycles hypervalent iodine oxidation |
| url | https://doi.org/10.3762/bjoc.20.258 |
| work_keys_str_mv | AT charubansal hypervalentiodinemediatedintramolecularalkenehalocyclisation AT oliverruggles hypervalentiodinemediatedintramolecularalkenehalocyclisation AT albertcrowett hypervalentiodinemediatedintramolecularalkenehalocyclisation AT alastairjjlennox hypervalentiodinemediatedintramolecularalkenehalocyclisation |