Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis
Platelets are small anucleate cell fragments that circulate in blood playing crucial role in managing vascular integrity and regulating hemostasis. Platelets are also involved in the fundamental biological process of chronic inflammation associated with disease pathology. Platelet indices like mean...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/781857 |
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| author | Kakali Ghoshal Maitree Bhattacharyya |
| author_facet | Kakali Ghoshal Maitree Bhattacharyya |
| author_sort | Kakali Ghoshal |
| collection | DOAJ |
| description | Platelets are small anucleate cell fragments that circulate in blood playing crucial role in managing vascular integrity and regulating hemostasis. Platelets are also involved in the fundamental biological process of chronic inflammation associated with disease pathology. Platelet indices like mean platelets volume (MPV), platelets distributed width (PDW), and platelet crit (PCT) are useful as cheap noninvasive biomarkers for assessing the diseased states. Dynamic platelets bear distinct morphology, where α and dense granule are actively involved in secretion of molecules like GPIIb , IIIa, fibrinogen, vWf, catecholamines, serotonin, calcium, ATP, ADP, and so forth, which are involved in aggregation. Differential expressions of surface receptors like CD36, CD41, CD61 and so forth have also been quantitated in several diseases. Platelet clinical research faces challenges due to the vulnerable nature of platelet structure functions and lack of accurate assay techniques. But recent advancement in flow cytometry inputs huge progress in the field of platelets study. Platelets activation and dysfunction have been implicated in diabetes, renal diseases, tumorigenesis, Alzheimer’s, and CVD. In conclusion, this paper elucidates that platelets are not that innocent as they keep showing and thus numerous novel platelet biomarkers are upcoming very soon in the field of clinical research which can be important for predicting and diagnosing disease state. |
| format | Article |
| id | doaj-art-fc94f9d501b4462ebc8fe0ed499954b0 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-fc94f9d501b4462ebc8fe0ed499954b02025-02-03T01:12:30ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/781857781857Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease PathogenesisKakali Ghoshal0Maitree Bhattacharyya1Department of Biochemistry, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700019, IndiaDepartment of Biochemistry, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700019, IndiaPlatelets are small anucleate cell fragments that circulate in blood playing crucial role in managing vascular integrity and regulating hemostasis. Platelets are also involved in the fundamental biological process of chronic inflammation associated with disease pathology. Platelet indices like mean platelets volume (MPV), platelets distributed width (PDW), and platelet crit (PCT) are useful as cheap noninvasive biomarkers for assessing the diseased states. Dynamic platelets bear distinct morphology, where α and dense granule are actively involved in secretion of molecules like GPIIb , IIIa, fibrinogen, vWf, catecholamines, serotonin, calcium, ATP, ADP, and so forth, which are involved in aggregation. Differential expressions of surface receptors like CD36, CD41, CD61 and so forth have also been quantitated in several diseases. Platelet clinical research faces challenges due to the vulnerable nature of platelet structure functions and lack of accurate assay techniques. But recent advancement in flow cytometry inputs huge progress in the field of platelets study. Platelets activation and dysfunction have been implicated in diabetes, renal diseases, tumorigenesis, Alzheimer’s, and CVD. In conclusion, this paper elucidates that platelets are not that innocent as they keep showing and thus numerous novel platelet biomarkers are upcoming very soon in the field of clinical research which can be important for predicting and diagnosing disease state.http://dx.doi.org/10.1155/2014/781857 |
| spellingShingle | Kakali Ghoshal Maitree Bhattacharyya Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis The Scientific World Journal |
| title | Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis |
| title_full | Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis |
| title_fullStr | Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis |
| title_full_unstemmed | Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis |
| title_short | Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis |
| title_sort | overview of platelet physiology its hemostatic and nonhemostatic role in disease pathogenesis |
| url | http://dx.doi.org/10.1155/2014/781857 |
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