Prime and pull of T cell responses against cancer-exogenous antigens is effective against CPI-resistant tumors

Prime and pull of T cell responses against cancer-exogenous antigens is effective against CPI-resistant tumors

Neoantigen (neoAg)-based cancer vaccines expand preexisting antitumor immunity and elicit novel cancer-specific T cells. However, at odds with prophylactic vaccines, therapeutic antitumor immunity must be induced when the tumor is present and has already established an immunosuppressive environment...

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Bibliographic Details
Main Authors: Fulvia Troise, Guido Leoni, Emanuele Sasso, Mariarosaria Del Sorbo, Marialuisa Esposito, Giuseppina Romano, Simona Allocca, Guendalina Froechlich, Gabriella Cotugno, Stefania Capone, Antonella Folgori, Elisa Scarselli, Anna Morena D’Alise, Alfredo Nicosia
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
cancer vaccine
adenovirus vectors
herpesvirus vectors
immune checkpoint inhibitors
neoantigens
Online Access:http://www.sciencedirect.com/science/article/pii/S295032992400002X
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