Safety Profile of the New 5-ASA Based Compounds
5-aminosalicylic acid (5-ASA) preparations were anticipated to be and generally are better tolerated than sulphasalazine. Minor side effects such as headache, dizziness, abdominal pain and nausea do occur but are not more frequent than in placebo-treated patients. Approximately 10% of patients thoug...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1990-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1990/345274 |
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| Summary: | 5-aminosalicylic acid (5-ASA) preparations were anticipated to
be and generally are better tolerated than sulphasalazine. Minor side effects such
as headache, dizziness, abdominal pain and nausea do occur but are not more
frequent than in placebo-treated patients. Approximately 10% of patients
thought to be allergic to sulphasalazine are also allergic to 5-ASA. An
idiosyncratic reaction with worsening of symptoms can occur. Diarrhea is more
common with olsalazine, and it is due to the effect of olsalazine itself on the small
bowel. not the 5-ASA component. There are case reports of pancreatitis,
pericarditis and bronchospasm, retrosternal chest pain, mild neutropenia,
nephrotic syndrome and hair loss associated with 5-ASA treatment. Patients
with oligospermia due to sulphasalazine have improved when switched to 5-ASA. 5-ASA enemas can cause local irritation or other effects resulting from
enema tip insertion. |
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| ISSN: | 0835-7900 |