The application of procyanidins in diabetes and its complications: a review of preclinical studies
Diabetes mellitus (DM) and its various complications, including diabetic nephropathy, retinopathy, neuropathy, cardiovascular disease, and ulcers, pose significant challenges to global health. This review investigates the potential of procyanidins (PCs), a natural polyphenolic compound, in preventin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1532246/full |
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| author | Yongchuang Zhang Mengna Li Haoyuan Liu Yongfu Fan Huan Huan Liu |
| author_facet | Yongchuang Zhang Mengna Li Haoyuan Liu Yongfu Fan Huan Huan Liu |
| author_sort | Yongchuang Zhang |
| collection | DOAJ |
| description | Diabetes mellitus (DM) and its various complications, including diabetic nephropathy, retinopathy, neuropathy, cardiovascular disease, and ulcers, pose significant challenges to global health. This review investigates the potential of procyanidins (PCs), a natural polyphenolic compound, in preventing and managing diabetes and its complications. PCs, recognized for their strong antioxidant, anti-inflammatory, and anti-hyperglycemic properties, play a crucial role in reducing oxidative stress and enhancing endothelial function, which are essential for managing diabetic complications. This review elucidates the molecular mechanisms by which PCs improve insulin sensitivity and endothelial health, thereby providing protection against the various complications of diabetes. The comprehensive analysis underscores the promising therapeutic role of PCs in diabetes care, indicating the need for further clinical studies to confirm and leverage their potential in comprehensive diabetes management strategies. |
| format | Article |
| id | doaj-art-fc26d1df02c1489cb11f9cc947337261 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-fc26d1df02c1489cb11f9cc9473372612025-02-10T06:48:31ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-02-011610.3389/fphar.2025.15322461532246The application of procyanidins in diabetes and its complications: a review of preclinical studiesYongchuang Zhang0Mengna Li1Haoyuan Liu2Yongfu Fan3Huan Huan Liu4Department of Rehabilitation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaInstitute of Pain Medicine and Special Environmental Medicine, Nantong University, Nantong, ChinaRehabilitation Department, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, ChinaSchool of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou, ChinaInternational institute for Traditional Chinese Medicine, Guanzhou University of Chinese Medicine, Guangzhou, ChinaDiabetes mellitus (DM) and its various complications, including diabetic nephropathy, retinopathy, neuropathy, cardiovascular disease, and ulcers, pose significant challenges to global health. This review investigates the potential of procyanidins (PCs), a natural polyphenolic compound, in preventing and managing diabetes and its complications. PCs, recognized for their strong antioxidant, anti-inflammatory, and anti-hyperglycemic properties, play a crucial role in reducing oxidative stress and enhancing endothelial function, which are essential for managing diabetic complications. This review elucidates the molecular mechanisms by which PCs improve insulin sensitivity and endothelial health, thereby providing protection against the various complications of diabetes. The comprehensive analysis underscores the promising therapeutic role of PCs in diabetes care, indicating the need for further clinical studies to confirm and leverage their potential in comprehensive diabetes management strategies.https://www.frontiersin.org/articles/10.3389/fphar.2025.1532246/fulldiabetes mellitusprocyanidinsantioxidantanti-inflammatoryinsulin sensitivity |
| spellingShingle | Yongchuang Zhang Mengna Li Haoyuan Liu Yongfu Fan Huan Huan Liu The application of procyanidins in diabetes and its complications: a review of preclinical studies Frontiers in Pharmacology diabetes mellitus procyanidins antioxidant anti-inflammatory insulin sensitivity |
| title | The application of procyanidins in diabetes and its complications: a review of preclinical studies |
| title_full | The application of procyanidins in diabetes and its complications: a review of preclinical studies |
| title_fullStr | The application of procyanidins in diabetes and its complications: a review of preclinical studies |
| title_full_unstemmed | The application of procyanidins in diabetes and its complications: a review of preclinical studies |
| title_short | The application of procyanidins in diabetes and its complications: a review of preclinical studies |
| title_sort | application of procyanidins in diabetes and its complications a review of preclinical studies |
| topic | diabetes mellitus procyanidins antioxidant anti-inflammatory insulin sensitivity |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1532246/full |
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