Management of a Patient with Metastatic Colorectal Cancer and Liver Metastases
Liver metastases are commonly encountered in patients presenting with metastatic colorectal cancer (mCRC); resection is the treatment of choice. A number of systemic treatment options are currently available for such patients, including the use of 5-fluorouracil-based chemotherapies and oxaliplatin...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/790192 |
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| author | Muhammad Wasif Saif |
| author_facet | Muhammad Wasif Saif |
| author_sort | Muhammad Wasif Saif |
| collection | DOAJ |
| description | Liver metastases are commonly encountered in patients presenting with metastatic colorectal cancer (mCRC); resection is the treatment of choice. A number of systemic treatment options are currently available for such patients, including the use of 5-fluorouracil-based chemotherapies and oxaliplatin (e.g., FOLFOX) in combination with biologic agents that target angiogenesis (e.g., bevacizumab). For patients with progression following first-line treatment, current second-line options include a change in chemotherapy with bevacizumab (for patients who did or did not receive prior bevacizumab) or FOLFIRI in combination with aflibercept, a more recently approved antiangiogenesis therapy. Neurotoxicity is a well-established adverse event of oxaliplatin-based therapy. The current case details an mCRC patient with liver metastases who was treated with a capecitabine and oxaliplatin regimen (XELOX), and experienced two episodes of transient cortical blindness possibly related to oxaliplatin. After disease progression, the patient was switched to a regimen of FOLFIRI and aflibercept and did well on this second-line regimen. |
| format | Article |
| id | doaj-art-fc11c1b1da744e9391cac2885bcdafd4 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-fc11c1b1da744e9391cac2885bcdafd42025-02-03T01:25:59ZengWileyCase Reports in Oncological Medicine2090-67062090-67142014-01-01201410.1155/2014/790192790192Management of a Patient with Metastatic Colorectal Cancer and Liver MetastasesMuhammad Wasif Saif0Tufts University School of Medicine, 800 Washington Street, Suite 7S-7099, Boston, MA 02111, USALiver metastases are commonly encountered in patients presenting with metastatic colorectal cancer (mCRC); resection is the treatment of choice. A number of systemic treatment options are currently available for such patients, including the use of 5-fluorouracil-based chemotherapies and oxaliplatin (e.g., FOLFOX) in combination with biologic agents that target angiogenesis (e.g., bevacizumab). For patients with progression following first-line treatment, current second-line options include a change in chemotherapy with bevacizumab (for patients who did or did not receive prior bevacizumab) or FOLFIRI in combination with aflibercept, a more recently approved antiangiogenesis therapy. Neurotoxicity is a well-established adverse event of oxaliplatin-based therapy. The current case details an mCRC patient with liver metastases who was treated with a capecitabine and oxaliplatin regimen (XELOX), and experienced two episodes of transient cortical blindness possibly related to oxaliplatin. After disease progression, the patient was switched to a regimen of FOLFIRI and aflibercept and did well on this second-line regimen.http://dx.doi.org/10.1155/2014/790192 |
| spellingShingle | Muhammad Wasif Saif Management of a Patient with Metastatic Colorectal Cancer and Liver Metastases Case Reports in Oncological Medicine |
| title | Management of a Patient with Metastatic Colorectal Cancer and Liver Metastases |
| title_full | Management of a Patient with Metastatic Colorectal Cancer and Liver Metastases |
| title_fullStr | Management of a Patient with Metastatic Colorectal Cancer and Liver Metastases |
| title_full_unstemmed | Management of a Patient with Metastatic Colorectal Cancer and Liver Metastases |
| title_short | Management of a Patient with Metastatic Colorectal Cancer and Liver Metastases |
| title_sort | management of a patient with metastatic colorectal cancer and liver metastases |
| url | http://dx.doi.org/10.1155/2014/790192 |
| work_keys_str_mv | AT muhammadwasifsaif managementofapatientwithmetastaticcolorectalcancerandlivermetastases |