Chemical Biology of G-quadruplex and i-motif DNA: use of topologically constrained DNA
Tetrameric DNA structures such as G-quadruplex (G4) and i-motif (i-DNA) have attracted increasing interest in the last decades. They are indeed involved in many biological processes including translation regulation, pre-mRNA processing, mRNA targeting, telomere maintenance, etc. We have developed ch...
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Académie des sciences
2023-10-01
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| Series: | Comptes Rendus. Chimie |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.256/ |
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| author | Dejeu, Jérôme Defrancq, Eric |
| author_facet | Dejeu, Jérôme Defrancq, Eric |
| author_sort | Dejeu, Jérôme |
| collection | DOAJ |
| description | Tetrameric DNA structures such as G-quadruplex (G4) and i-motif (i-DNA) have attracted increasing interest in the last decades. They are indeed involved in many biological processes including translation regulation, pre-mRNA processing, mRNA targeting, telomere maintenance, etc. We have developed chemical tools named TASQ (Template-Assembled Synthetic Quadruplex) to address the following scientific goals: (i) identify unambiguous (i.e., affine and specific) G4- and i-DNA-interacting ligands, (ii) identify proteins interacting with those structures and determine their cellular relevance and (iii) select specific antibodies for G4 and i-DNA. This review reports on our works over the past decade. |
| format | Article |
| id | doaj-art-fc04856170cc464fb12e830250d44181 |
| institution | Kabale University |
| issn | 1878-1543 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus. Chimie |
| spelling | doaj-art-fc04856170cc464fb12e830250d441812025-02-07T13:38:53ZengAcadémie des sciencesComptes Rendus. Chimie1878-15432023-10-0126S3395210.5802/crchim.25610.5802/crchim.256Chemical Biology of G-quadruplex and i-motif DNA: use of topologically constrained DNADejeu, Jérôme0https://orcid.org/0000-0002-2434-2959Defrancq, Eric1https://orcid.org/0000-0002-3911-6241SUPMICROTECH, Université de Franche-Comté, CNRS, Institut FEMTO-ST, F-25000 Besançon, France; Université Grenoble-Alpes, CNRS, UMR 5250, Département de Chimie Moléculaire (DCM), 38000 Grenoble, FranceUniversité Grenoble-Alpes, CNRS, UMR 5250, Département de Chimie Moléculaire (DCM), 38000 Grenoble, FranceTetrameric DNA structures such as G-quadruplex (G4) and i-motif (i-DNA) have attracted increasing interest in the last decades. They are indeed involved in many biological processes including translation regulation, pre-mRNA processing, mRNA targeting, telomere maintenance, etc. We have developed chemical tools named TASQ (Template-Assembled Synthetic Quadruplex) to address the following scientific goals: (i) identify unambiguous (i.e., affine and specific) G4- and i-DNA-interacting ligands, (ii) identify proteins interacting with those structures and determine their cellular relevance and (iii) select specific antibodies for G4 and i-DNA. This review reports on our works over the past decade.https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.256/G-quadruplexi-motifDNASPRBLIOligonucleotide conjugateClick chemistry |
| spellingShingle | Dejeu, Jérôme Defrancq, Eric Chemical Biology of G-quadruplex and i-motif DNA: use of topologically constrained DNA Comptes Rendus. Chimie G-quadruplex i-motif DNA SPR BLI Oligonucleotide conjugate Click chemistry |
| title | Chemical Biology of G-quadruplex and i-motif DNA: use of topologically constrained DNA |
| title_full | Chemical Biology of G-quadruplex and i-motif DNA: use of topologically constrained DNA |
| title_fullStr | Chemical Biology of G-quadruplex and i-motif DNA: use of topologically constrained DNA |
| title_full_unstemmed | Chemical Biology of G-quadruplex and i-motif DNA: use of topologically constrained DNA |
| title_short | Chemical Biology of G-quadruplex and i-motif DNA: use of topologically constrained DNA |
| title_sort | chemical biology of g quadruplex and i motif dna use of topologically constrained dna |
| topic | G-quadruplex i-motif DNA SPR BLI Oligonucleotide conjugate Click chemistry |
| url | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.256/ |
| work_keys_str_mv | AT dejeujerome chemicalbiologyofgquadruplexandimotifdnauseoftopologicallyconstraineddna AT defrancqeric chemicalbiologyofgquadruplexandimotifdnauseoftopologicallyconstraineddna |