Chemical Biology of G-quadruplex and i-motif DNA: use of topologically constrained DNA
Tetrameric DNA structures such as G-quadruplex (G4) and i-motif (i-DNA) have attracted increasing interest in the last decades. They are indeed involved in many biological processes including translation regulation, pre-mRNA processing, mRNA targeting, telomere maintenance, etc. We have developed ch...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Académie des sciences
2023-10-01
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| Series: | Comptes Rendus. Chimie |
| Subjects: | |
| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.256/ |
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| Summary: | Tetrameric DNA structures such as G-quadruplex (G4) and i-motif (i-DNA) have attracted increasing interest in the last decades. They are indeed involved in many biological processes including translation regulation, pre-mRNA processing, mRNA targeting, telomere maintenance, etc. We have developed chemical tools named TASQ (Template-Assembled Synthetic Quadruplex) to address the following scientific goals: (i) identify unambiguous (i.e., affine and specific) G4- and i-DNA-interacting ligands, (ii) identify proteins interacting with those structures and determine their cellular relevance and (iii) select specific antibodies for G4 and i-DNA. This review reports on our works over the past decade. |
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| ISSN: | 1878-1543 |