The relationship of cholecalciferol and parathyroid hormone with metabolic disorders in patients with arterial hypertension
Background. Essential hypertension (EH) is a complex, multifactorial and polygenic disease. Despite effective measures for control and modification of traditional risk factors, a significant amount of risk remains. The aim of the study was to evaluate changes in clinical parameters and to analyze th...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Zaslavsky O.Yu.
2024-06-01
|
| Series: | Mìžnarodnij Endokrinologìčnij Žurnal |
| Subjects: | |
| Online Access: | https://iej.zaslavsky.com.ua/index.php/journal/article/view/1401 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849221770581639168 |
|---|---|
| author | M.M. Semіaniv L.P. Sydorchuk Yu.M. Yarynych Sai Praveen Daruvuri S.B. Semenenko O.I. Sydorchuk |
| author_facet | M.M. Semіaniv L.P. Sydorchuk Yu.M. Yarynych Sai Praveen Daruvuri S.B. Semenenko O.I. Sydorchuk |
| author_sort | M.M. Semіaniv |
| collection | DOAJ |
| description | Background. Essential hypertension (EH) is a complex, multifactorial and polygenic disease. Despite effective measures for control and modification of traditional risk factors, a significant amount of risk remains. The aim of the study was to evaluate changes in clinical parameters and to analyze the relationship of cholecalciferol, parathyroid hormone with anthropometric, metabolic parameters in patients with EH. Materials and methods. One hundred subjects with EH and target organ damage (stage 2), moderate, high, very high cardiovascular risk were enrolled in case-control study. Control group consisted of 60 healthy subjects matched for sex and age. Pearson’s test was used to determine the relationship between parameters in case of categorical variables; analysis of variance (ANOVA) when one of the variables is categorical and the other is numerical (interval); non-parametric Kruskal-Wallis test in case of abnormal array distribution. Results. Development and course of EH is characterized by clinical, hemodynamic, metabolic abnormalities that are nonlinearly exacerbated with the severity of hypertension. Correlation analysis showed a direct relationship between body weight and waist-to-hip ratio (r = 0.76–0.88; р < 0.001); systolic blood pressure is moderately directly correlated with waist circumference (WC) (r = 0.38; р < 0.05); total cholesterol is strongly associated with low-density lipoprotein cholesterol (r = 0.93; р < 0.001), high-density lipoprotein cholesterol (HDL-C) is inversely associated with WC (r = –0.40; р < 0.05) and triacylglycerol levels (r = –0.41; р < 0.001), and cholecalciferol concentration is negatively marginally associated with body mass index, waist-to-hip ratio (r = –0.41/–0.38; р < 0.05). ANOVA confirmed that plasma cholecalciferol was associated with body weight (F = 6.48; р = 0.013), height (F = 4.33; р = 0.04), WC (χ2 = 15.93; р < 0.001), blood glucose (χ2 = 10.66; р = 0.001) and HDL-С (F = 6.53; р = 0.012). Reliable relationship between parathyroid hormone and waist-to-hip ratio was found (χ2 = 6.86; р = 0.032). Conclusions. In EH patients, plasma cholecalciferol significantly correlates with body weight, height, WC, glucose level, HDL-С. Parathyroid hormone has a significant and direct relationship with waist-to-hip ratio. |
| format | Article |
| id | doaj-art-fbff1d85d1314a6db4c6a654198c755c |
| institution | Kabale University |
| issn | 2224-0721 2307-1427 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Mìžnarodnij Endokrinologìčnij Žurnal |
| spelling | doaj-art-fbff1d85d1314a6db4c6a654198c755c2024-11-10T19:05:51ZengZaslavsky O.Yu.Mìžnarodnij Endokrinologìčnij Žurnal2224-07212307-14272024-06-0120424425010.22141/2224-0721.20.4.2024.14011399The relationship of cholecalciferol and parathyroid hormone with metabolic disorders in patients with arterial hypertensionM.M. Semіaniv0https://orcid.org/0000-0003-4169-7142L.P. Sydorchuk1https://orcid.org/0000-0001-9279-9531Yu.M. Yarynych2https://orcid.org/0000-0002-9599-038XSai Praveen Daruvuri3https://orcid.org/0009-0007-6789-583XS.B. Semenenko4https://orcid.org/0000-0002-6124-1938O.I. Sydorchuk5https://orcid.org/0000-0002-6209-1353Bukovinian State Medical University, Chernivtsi, UkraineBukovinian State Medical University, Chernivtsi, UkraineBukovinian State Medical University, Chernivtsi, UkraineSt. Mary’s General Hospital, Passaic, New Jersey, USABukovinian State Medical University, Chernivtsi, UkraineBogomolets National Medical University, Kyiv, UkraineBackground. Essential hypertension (EH) is a complex, multifactorial and polygenic disease. Despite effective measures for control and modification of traditional risk factors, a significant amount of risk remains. The aim of the study was to evaluate changes in clinical parameters and to analyze the relationship of cholecalciferol, parathyroid hormone with anthropometric, metabolic parameters in patients with EH. Materials and methods. One hundred subjects with EH and target organ damage (stage 2), moderate, high, very high cardiovascular risk were enrolled in case-control study. Control group consisted of 60 healthy subjects matched for sex and age. Pearson’s test was used to determine the relationship between parameters in case of categorical variables; analysis of variance (ANOVA) when one of the variables is categorical and the other is numerical (interval); non-parametric Kruskal-Wallis test in case of abnormal array distribution. Results. Development and course of EH is characterized by clinical, hemodynamic, metabolic abnormalities that are nonlinearly exacerbated with the severity of hypertension. Correlation analysis showed a direct relationship between body weight and waist-to-hip ratio (r = 0.76–0.88; р < 0.001); systolic blood pressure is moderately directly correlated with waist circumference (WC) (r = 0.38; р < 0.05); total cholesterol is strongly associated with low-density lipoprotein cholesterol (r = 0.93; р < 0.001), high-density lipoprotein cholesterol (HDL-C) is inversely associated with WC (r = –0.40; р < 0.05) and triacylglycerol levels (r = –0.41; р < 0.001), and cholecalciferol concentration is negatively marginally associated with body mass index, waist-to-hip ratio (r = –0.41/–0.38; р < 0.05). ANOVA confirmed that plasma cholecalciferol was associated with body weight (F = 6.48; р = 0.013), height (F = 4.33; р = 0.04), WC (χ2 = 15.93; р < 0.001), blood glucose (χ2 = 10.66; р = 0.001) and HDL-С (F = 6.53; р = 0.012). Reliable relationship between parathyroid hormone and waist-to-hip ratio was found (χ2 = 6.86; р = 0.032). Conclusions. In EH patients, plasma cholecalciferol significantly correlates with body weight, height, WC, glucose level, HDL-С. Parathyroid hormone has a significant and direct relationship with waist-to-hip ratio.https://iej.zaslavsky.com.ua/index.php/journal/article/view/1401essential hypertensioncholecalciferolparathyroid hormonemetabolic parametersrelationship |
| spellingShingle | M.M. Semіaniv L.P. Sydorchuk Yu.M. Yarynych Sai Praveen Daruvuri S.B. Semenenko O.I. Sydorchuk The relationship of cholecalciferol and parathyroid hormone with metabolic disorders in patients with arterial hypertension Mìžnarodnij Endokrinologìčnij Žurnal essential hypertension cholecalciferol parathyroid hormone metabolic parameters relationship |
| title | The relationship of cholecalciferol and parathyroid hormone with metabolic disorders in patients with arterial hypertension |
| title_full | The relationship of cholecalciferol and parathyroid hormone with metabolic disorders in patients with arterial hypertension |
| title_fullStr | The relationship of cholecalciferol and parathyroid hormone with metabolic disorders in patients with arterial hypertension |
| title_full_unstemmed | The relationship of cholecalciferol and parathyroid hormone with metabolic disorders in patients with arterial hypertension |
| title_short | The relationship of cholecalciferol and parathyroid hormone with metabolic disorders in patients with arterial hypertension |
| title_sort | relationship of cholecalciferol and parathyroid hormone with metabolic disorders in patients with arterial hypertension |
| topic | essential hypertension cholecalciferol parathyroid hormone metabolic parameters relationship |
| url | https://iej.zaslavsky.com.ua/index.php/journal/article/view/1401 |
| work_keys_str_mv | AT mmsemíaniv therelationshipofcholecalciferolandparathyroidhormonewithmetabolicdisordersinpatientswitharterialhypertension AT lpsydorchuk therelationshipofcholecalciferolandparathyroidhormonewithmetabolicdisordersinpatientswitharterialhypertension AT yumyarynych therelationshipofcholecalciferolandparathyroidhormonewithmetabolicdisordersinpatientswitharterialhypertension AT saipraveendaruvuri therelationshipofcholecalciferolandparathyroidhormonewithmetabolicdisordersinpatientswitharterialhypertension AT sbsemenenko therelationshipofcholecalciferolandparathyroidhormonewithmetabolicdisordersinpatientswitharterialhypertension AT oisydorchuk therelationshipofcholecalciferolandparathyroidhormonewithmetabolicdisordersinpatientswitharterialhypertension AT mmsemíaniv relationshipofcholecalciferolandparathyroidhormonewithmetabolicdisordersinpatientswitharterialhypertension AT lpsydorchuk relationshipofcholecalciferolandparathyroidhormonewithmetabolicdisordersinpatientswitharterialhypertension AT yumyarynych relationshipofcholecalciferolandparathyroidhormonewithmetabolicdisordersinpatientswitharterialhypertension AT saipraveendaruvuri relationshipofcholecalciferolandparathyroidhormonewithmetabolicdisordersinpatientswitharterialhypertension AT sbsemenenko relationshipofcholecalciferolandparathyroidhormonewithmetabolicdisordersinpatientswitharterialhypertension AT oisydorchuk relationshipofcholecalciferolandparathyroidhormonewithmetabolicdisordersinpatientswitharterialhypertension |