Matrix metalloproteinase-9 index as a possible parameter for predicting acute coronary syndrome in diabetics
Background/Aim. Matrix metalloproteinase-9 (MMP-9) index is the ratio of active MMP-9 and total MMP-9 levels. It reflects the importance of MMP-9 in acute coronary syndrome (ACS). Methods. The study included 3 groups of patients (n = 87): the group 1 - non-diabetic subjects without ACS (...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2015-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501400055P.pdf |
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| Summary: | Background/Aim. Matrix metalloproteinase-9 (MMP-9) index is the ratio of
active MMP-9 and total MMP-9 levels. It reflects the importance of MMP-9 in
acute coronary syndrome (ACS). Methods. The study included 3 groups of
patients (n = 87): the group 1 - non-diabetic subjects without ACS
(control); the group 2 - diabetic patients with ACS [subgroups with unstable
angina pectoris (UAP), myocardial infarction (MI) or reinfarction]; and the
group 3 non-diabetics patients with ACS. Total and active MMP-9 were
measured and used to create MMP-9 index. Results. MMP-9 index, as a marker
showed good sensitivity and specificity, of ACS in diabetics, with a cut-off
value over 58.2. MMP-9 was higher in the study groups than in the control
one. MMP-9 correlated with ACS occurrence and type of cardiovascular event.
A statistically significant difference was found among the groups according
to active MMP-9 (p < 0.001). The same was found with active MMP-9 between
the control and the group with MI (p < 0.001). The control was highly
statistically significantly different from the group of patients with UAP (p
< 0.01). Statically significant differences in MMP-9 index was found between
the control and the diabetics with ACS (p < 0.001). Statistically
significant difference of MMP-9 index was also found in the controls
compared to the value in non-diabetic patients with ACS (p < 0.01).
Conclusion. MMP-9 index may be a possible marker of atheromatous plaque
rupture in diabetics. |
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| ISSN: | 0042-8450 |