SELECTION OF THERAPEUTIC TACTICS FOR EARLY ANEMIA OF PREMATURE INFANTS WITH VERY LOW OR EXTREMELY LOW BIRTH WEIGHT: RETROSPECTIVE STUDY RESULTS
Background: Early anemia of prematurity (EAP) is a serious issue of contemporary neonatology due to increasing survivability of premature infants. One of the most efficient preventive methods is extreme prematurity prevention. At the same time, efficacy of different methods of EAP therapy remains un...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Union of pediatricians of Russia
2016-02-01
|
| Series: | Педиатрическая фармакология |
| Subjects: | |
| Online Access: | https://www.pedpharma.ru/jour/article/view/1363 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849395791505915904 |
|---|---|
| author | O. A. Senkevich E. A. Smetanina A. N. Yilg |
| author_facet | O. A. Senkevich E. A. Smetanina A. N. Yilg |
| author_sort | O. A. Senkevich |
| collection | DOAJ |
| description | Background: Early anemia of prematurity (EAP) is a serious issue of contemporary neonatology due to increasing survivability of premature infants. One of the most efficient preventive methods is extreme prematurity prevention. At the same time, efficacy of different methods of EAP therapy remains undetermined.Objective: Our aim was to compare efficacy of erythrocyte-containing donor blood components (packed red cells, erythrocytic suspension) and recombinant epoetin beta for treating premature infants with EAP.Methods: The retrospective cohort study provided analysis of data of premature infants (gestation age — 27–32 weeks) born with very low (VLBW) and extremely low birth weight (ELBW) and EAP (hemoglobin < 110 g/l, hematocrit < 27%, reticulocyte share < 20‰, normochromia, normocytosis; all criteria must have been met). We determined primary hematological morphological parameters and population structure of umbilical (at birth) and peripheral blood (after 30 days of treatment) leukocytes.Results: 32 premature infants with EAP underwent donor blood component transfusions, 26 — recombinant epoetin beta injections. The groups were comparable in terms of the primary clinical laboratory parameters. In the donor blood component group, we observed lower hemoglobin concentration (108 ± 17 vs. 119 ± 16 g/l in the epoetin beta group; p = 0.07) and reticulocyte share (3.7 ± 1.5 vs. 8.7 ± 1.7‰, respectively; p = 0,053) at the age of 1 month. We revealed a drop in cell immunity parameters in the setting of donor blood component transfusions: CD4+ lymphocyte share — down to 32,2 ± 14,0% (in the epoetin beta group; p = 0.055); CD8+ lymphocyte share — down to 21,2 ± 7,1% (in the epoetin beta group; p = 0.050).Conclusion: Epoetin beta is more efficient in terms of EAP correction in premature infants with VLBW and ELBW that erythrocyte-containing donor blood component transfusions. The latter are characterized by adverse effect on cell immunity parameters. |
| format | Article |
| id | doaj-art-fbfc36e836c645cf84923e148dcd579c |
| institution | Kabale University |
| issn | 1727-5776 2500-3089 |
| language | Russian |
| publishDate | 2016-02-01 |
| publisher | Union of pediatricians of Russia |
| record_format | Article |
| series | Педиатрическая фармакология |
| spelling | doaj-art-fbfc36e836c645cf84923e148dcd579c2025-08-20T03:39:29ZrusUnion of pediatricians of RussiaПедиатрическая фармакология1727-57762500-30892016-02-01131333710.15690/pf.v13i1.15121355SELECTION OF THERAPEUTIC TACTICS FOR EARLY ANEMIA OF PREMATURE INFANTS WITH VERY LOW OR EXTREMELY LOW BIRTH WEIGHT: RETROSPECTIVE STUDY RESULTSO. A. Senkevich0E. A. Smetanina1A. N. Yilg2Far Eastern State UniversityСlinic «The Mother and Child»Far Eastern State UniversityBackground: Early anemia of prematurity (EAP) is a serious issue of contemporary neonatology due to increasing survivability of premature infants. One of the most efficient preventive methods is extreme prematurity prevention. At the same time, efficacy of different methods of EAP therapy remains undetermined.Objective: Our aim was to compare efficacy of erythrocyte-containing donor blood components (packed red cells, erythrocytic suspension) and recombinant epoetin beta for treating premature infants with EAP.Methods: The retrospective cohort study provided analysis of data of premature infants (gestation age — 27–32 weeks) born with very low (VLBW) and extremely low birth weight (ELBW) and EAP (hemoglobin < 110 g/l, hematocrit < 27%, reticulocyte share < 20‰, normochromia, normocytosis; all criteria must have been met). We determined primary hematological morphological parameters and population structure of umbilical (at birth) and peripheral blood (after 30 days of treatment) leukocytes.Results: 32 premature infants with EAP underwent donor blood component transfusions, 26 — recombinant epoetin beta injections. The groups were comparable in terms of the primary clinical laboratory parameters. In the donor blood component group, we observed lower hemoglobin concentration (108 ± 17 vs. 119 ± 16 g/l in the epoetin beta group; p = 0.07) and reticulocyte share (3.7 ± 1.5 vs. 8.7 ± 1.7‰, respectively; p = 0,053) at the age of 1 month. We revealed a drop in cell immunity parameters in the setting of donor blood component transfusions: CD4+ lymphocyte share — down to 32,2 ± 14,0% (in the epoetin beta group; p = 0.055); CD8+ lymphocyte share — down to 21,2 ± 7,1% (in the epoetin beta group; p = 0.050).Conclusion: Epoetin beta is more efficient in terms of EAP correction in premature infants with VLBW and ELBW that erythrocyte-containing donor blood component transfusions. The latter are characterized by adverse effect on cell immunity parameters.https://www.pedpharma.ru/jour/article/view/1363childrenpremature infantsanemiahemotransfusionrecombinant epoetin betacell immunity |
| spellingShingle | O. A. Senkevich E. A. Smetanina A. N. Yilg SELECTION OF THERAPEUTIC TACTICS FOR EARLY ANEMIA OF PREMATURE INFANTS WITH VERY LOW OR EXTREMELY LOW BIRTH WEIGHT: RETROSPECTIVE STUDY RESULTS Педиатрическая фармакология children premature infants anemia hemotransfusion recombinant epoetin beta cell immunity |
| title | SELECTION OF THERAPEUTIC TACTICS FOR EARLY ANEMIA OF PREMATURE INFANTS WITH VERY LOW OR EXTREMELY LOW BIRTH WEIGHT: RETROSPECTIVE STUDY RESULTS |
| title_full | SELECTION OF THERAPEUTIC TACTICS FOR EARLY ANEMIA OF PREMATURE INFANTS WITH VERY LOW OR EXTREMELY LOW BIRTH WEIGHT: RETROSPECTIVE STUDY RESULTS |
| title_fullStr | SELECTION OF THERAPEUTIC TACTICS FOR EARLY ANEMIA OF PREMATURE INFANTS WITH VERY LOW OR EXTREMELY LOW BIRTH WEIGHT: RETROSPECTIVE STUDY RESULTS |
| title_full_unstemmed | SELECTION OF THERAPEUTIC TACTICS FOR EARLY ANEMIA OF PREMATURE INFANTS WITH VERY LOW OR EXTREMELY LOW BIRTH WEIGHT: RETROSPECTIVE STUDY RESULTS |
| title_short | SELECTION OF THERAPEUTIC TACTICS FOR EARLY ANEMIA OF PREMATURE INFANTS WITH VERY LOW OR EXTREMELY LOW BIRTH WEIGHT: RETROSPECTIVE STUDY RESULTS |
| title_sort | selection of therapeutic tactics for early anemia of premature infants with very low or extremely low birth weight retrospective study results |
| topic | children premature infants anemia hemotransfusion recombinant epoetin beta cell immunity |
| url | https://www.pedpharma.ru/jour/article/view/1363 |
| work_keys_str_mv | AT oasenkevich selectionoftherapeutictacticsforearlyanemiaofprematureinfantswithveryloworextremelylowbirthweightretrospectivestudyresults AT easmetanina selectionoftherapeutictacticsforearlyanemiaofprematureinfantswithveryloworextremelylowbirthweightretrospectivestudyresults AT anyilg selectionoftherapeutictacticsforearlyanemiaofprematureinfantswithveryloworextremelylowbirthweightretrospectivestudyresults |