A Case Report of Giant Congenital Melanocytic Nevus Complicated by Minimal Change Disease, With Genetic Analysis
ABSTRACT This case describes a 39‐year‐old woman with congenital giant melanocytic nevus (GCMN) who developed new‐onset nephrotic syndrome. Clinical evaluation revealed minimal change disease (MCD) confirmed by renal biopsy, with podocyte effacement on electron microscopy. Genetic testing identified...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.70794 |
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| author | Geping Yu Ting Hu Ting Yu Yihan Zhao Xiao Xu |
| author_facet | Geping Yu Ting Hu Ting Yu Yihan Zhao Xiao Xu |
| author_sort | Geping Yu |
| collection | DOAJ |
| description | ABSTRACT This case describes a 39‐year‐old woman with congenital giant melanocytic nevus (GCMN) who developed new‐onset nephrotic syndrome. Clinical evaluation revealed minimal change disease (MCD) confirmed by renal biopsy, with podocyte effacement on electron microscopy. Genetic testing identified four variants of uncertain significance, with no known pathogenic mutations. Treatment with corticosteroids, losartan, and low‐molecular‐weight heparin led to remission, and no relapse occurred after one year. The GCMN remained unchanged. This rare co‐occurrence highlights the need to consider systemic associations in complex cases and suggests possible molecular links between dermatological and renal disorders requiring further investigation. |
| format | Article |
| id | doaj-art-fbfc2e628592424bbc3af0114dad806f |
| institution | Kabale University |
| issn | 2050-0904 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-fbfc2e628592424bbc3af0114dad806f2025-08-22T07:33:08ZengWileyClinical Case Reports2050-09042025-08-01138n/an/a10.1002/ccr3.70794A Case Report of Giant Congenital Melanocytic Nevus Complicated by Minimal Change Disease, With Genetic AnalysisGeping Yu0Ting Hu1Ting Yu2Yihan Zhao3Xiao Xu4Department of Nephrology, Hangzhou First People's Hospital Tonglu Campus, School of Medicine Westlake University Hangzhou People's Republic of ChinaDepartment of Nephrology, Hangzhou First People's Hospital Tonglu Campus, School of Medicine Westlake University Hangzhou People's Republic of ChinaDepartment of Nephrology, Hangzhou First People's Hospital Tonglu Campus, School of Medicine Westlake University Hangzhou People's Republic of ChinaDepartment of Nephrology, Hangzhou First People's Hospital Tonglu Campus, School of Medicine Westlake University Hangzhou People's Republic of ChinaDepartment of Nephrology, Hangzhou First People's Hospital Tonglu Campus, School of Medicine Westlake University Hangzhou People's Republic of ChinaABSTRACT This case describes a 39‐year‐old woman with congenital giant melanocytic nevus (GCMN) who developed new‐onset nephrotic syndrome. Clinical evaluation revealed minimal change disease (MCD) confirmed by renal biopsy, with podocyte effacement on electron microscopy. Genetic testing identified four variants of uncertain significance, with no known pathogenic mutations. Treatment with corticosteroids, losartan, and low‐molecular‐weight heparin led to remission, and no relapse occurred after one year. The GCMN remained unchanged. This rare co‐occurrence highlights the need to consider systemic associations in complex cases and suggests possible molecular links between dermatological and renal disorders requiring further investigation.https://doi.org/10.1002/ccr3.70794congenital giant congenital melanocytic nevusgeneticsminimal change diseasepodocyte injury |
| spellingShingle | Geping Yu Ting Hu Ting Yu Yihan Zhao Xiao Xu A Case Report of Giant Congenital Melanocytic Nevus Complicated by Minimal Change Disease, With Genetic Analysis Clinical Case Reports congenital giant congenital melanocytic nevus genetics minimal change disease podocyte injury |
| title | A Case Report of Giant Congenital Melanocytic Nevus Complicated by Minimal Change Disease, With Genetic Analysis |
| title_full | A Case Report of Giant Congenital Melanocytic Nevus Complicated by Minimal Change Disease, With Genetic Analysis |
| title_fullStr | A Case Report of Giant Congenital Melanocytic Nevus Complicated by Minimal Change Disease, With Genetic Analysis |
| title_full_unstemmed | A Case Report of Giant Congenital Melanocytic Nevus Complicated by Minimal Change Disease, With Genetic Analysis |
| title_short | A Case Report of Giant Congenital Melanocytic Nevus Complicated by Minimal Change Disease, With Genetic Analysis |
| title_sort | case report of giant congenital melanocytic nevus complicated by minimal change disease with genetic analysis |
| topic | congenital giant congenital melanocytic nevus genetics minimal change disease podocyte injury |
| url | https://doi.org/10.1002/ccr3.70794 |
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