Efficacy of trabeculectomy combined with collagen implant and mitomycin C compared to with mitomycin C alone in glaucoma: a retrospective cohort study
AIM: To compare trabeculectomy with mitomycin C (MMC) alone to trabeculectomy with a combination of MMC and Ologen implant in glaucoma patients. METHODS: A retrospective cohort study including 94 eyes recruited in two groups [50 in the mitomycin C (MMC) group and 44 in the combined Ologen+MMC (OLO)...
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Press of International Journal of Ophthalmology (IJO PRESS)
2025-06-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2025/6/20250609.pdf |
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| author | Medhat A Bakr Ussama Alnaqib Saleh S. Algamdi Hatim Najmi Askar K. Alshaibani Moataza M. Abdel Wahab Mohammed Barnawi Abdulaziz I. AlSomali Khalid B. Alburayk |
| author_facet | Medhat A Bakr Ussama Alnaqib Saleh S. Algamdi Hatim Najmi Askar K. Alshaibani Moataza M. Abdel Wahab Mohammed Barnawi Abdulaziz I. AlSomali Khalid B. Alburayk |
| author_sort | Medhat A Bakr |
| collection | DOAJ |
| description | AIM: To compare trabeculectomy with mitomycin C (MMC) alone to trabeculectomy with a combination of MMC and Ologen implant in glaucoma patients. METHODS: A retrospective cohort study including 94 eyes recruited in two groups [50 in the mitomycin C (MMC) group and 44 in the combined Ologen+MMC (OLO) group]. The medical charts of the patients were collected and analyzed at different time points: 1d, 10-30d, 3-5mo, 6-9mo, 1, 2, and 3y postoperatively. We assessed the intraocular pressure (IOP) reduction, cup-disc (CD) ratio, visual acuity (VA), bleb morphology, and complications. RESULTS: Both groups showed a significant reduction of the mean IOP from 28.8 to 10 mm Hg in 1 and 2y. However, no significant difference was noticed between both groups. We observed a stable visual acuity in 40% and 11.8%, improved in 20% and 41.2%, and worsened in 40% and 47.1% in the MMC and OLO groups, respectively. Complications were statistically significantly lower in the OLO group than in the MMC group. Bleb morphology showed statistically significant differences between the groups, with grade C blebs being more prevalent in the OLO group (43.2% in 1y) compared to the MMC group (16% in 1y) and flat blebs being more prevalent in the OLO group (43.2% in 2y) compare to MMC group (20% in 2y). Both MMC and OLO groups were effective in reducing IOP. CONCLUSION: The combined use of the Ologen implant and MMC may provide better outcomes in terms of preserving the optic nerve structure, reducing complications, and maintaining stable bleb morphology postoperatively. |
| format | Article |
| id | doaj-art-fbf689fe92ca4ec58540232ba58a3f83 |
| institution | Kabale University |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
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| series | International Journal of Ophthalmology |
| spelling | doaj-art-fbf689fe92ca4ec58540232ba58a3f832025-08-20T03:47:33ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982025-06-011861032104110.18240/ijo.2025.06.0920250609Efficacy of trabeculectomy combined with collagen implant and mitomycin C compared to with mitomycin C alone in glaucoma: a retrospective cohort studyMedhat A Bakr0Ussama Alnaqib1Saleh S. Algamdi2Hatim Najmi3Askar K. Alshaibani4Moataza M. Abdel Wahab5Mohammed Barnawi6Abdulaziz I. AlSomali7Khalid B. Alburayk8Medhat A Bakr. Ophthalmology Department, Imam Abdulrahman Bin Faisal University, Dammam 34221, Saudi Arabia. medhat_6@hotmail.comGlaucoma Department, Dhahran Eye Specialist Hospital, Dhahran 34257, Saudi ArabiaOphthalmology Department, Imam Abdulrahman Bin Faisal University, Dammam 34221, Saudi ArabiaDhahran Eye Specialist Hospital, Dhahran 34257, Saudi ArabiaDhahran Eye Specialist Hospital, Dhahran 34257, Saudi ArabiaFamily and Community Medicine Department, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi ArabiaPostgraduate Training Program for Preventive Medicine in Taif, Ministry of Health, Taif 21944, Saudi ArabiaKing Faisal University, Ahsaa 31982, Saudi ArabiaOphthalmology Department, Imam Abdulrahman Bin Faisal University, Dammam 34221, Saudi ArabiaAIM: To compare trabeculectomy with mitomycin C (MMC) alone to trabeculectomy with a combination of MMC and Ologen implant in glaucoma patients. METHODS: A retrospective cohort study including 94 eyes recruited in two groups [50 in the mitomycin C (MMC) group and 44 in the combined Ologen+MMC (OLO) group]. The medical charts of the patients were collected and analyzed at different time points: 1d, 10-30d, 3-5mo, 6-9mo, 1, 2, and 3y postoperatively. We assessed the intraocular pressure (IOP) reduction, cup-disc (CD) ratio, visual acuity (VA), bleb morphology, and complications. RESULTS: Both groups showed a significant reduction of the mean IOP from 28.8 to 10 mm Hg in 1 and 2y. However, no significant difference was noticed between both groups. We observed a stable visual acuity in 40% and 11.8%, improved in 20% and 41.2%, and worsened in 40% and 47.1% in the MMC and OLO groups, respectively. Complications were statistically significantly lower in the OLO group than in the MMC group. Bleb morphology showed statistically significant differences between the groups, with grade C blebs being more prevalent in the OLO group (43.2% in 1y) compared to the MMC group (16% in 1y) and flat blebs being more prevalent in the OLO group (43.2% in 2y) compare to MMC group (20% in 2y). Both MMC and OLO groups were effective in reducing IOP. CONCLUSION: The combined use of the Ologen implant and MMC may provide better outcomes in terms of preserving the optic nerve structure, reducing complications, and maintaining stable bleb morphology postoperatively.http://ies.ijo.cn/en_publish/2025/6/20250609.pdfologen implantmitomycin cintraocular pressureglaucomatrabeculectomy |
| spellingShingle | Medhat A Bakr Ussama Alnaqib Saleh S. Algamdi Hatim Najmi Askar K. Alshaibani Moataza M. Abdel Wahab Mohammed Barnawi Abdulaziz I. AlSomali Khalid B. Alburayk Efficacy of trabeculectomy combined with collagen implant and mitomycin C compared to with mitomycin C alone in glaucoma: a retrospective cohort study International Journal of Ophthalmology ologen implant mitomycin c intraocular pressure glaucoma trabeculectomy |
| title | Efficacy of trabeculectomy combined with collagen implant and mitomycin C compared to with mitomycin C alone in glaucoma: a retrospective cohort study |
| title_full | Efficacy of trabeculectomy combined with collagen implant and mitomycin C compared to with mitomycin C alone in glaucoma: a retrospective cohort study |
| title_fullStr | Efficacy of trabeculectomy combined with collagen implant and mitomycin C compared to with mitomycin C alone in glaucoma: a retrospective cohort study |
| title_full_unstemmed | Efficacy of trabeculectomy combined with collagen implant and mitomycin C compared to with mitomycin C alone in glaucoma: a retrospective cohort study |
| title_short | Efficacy of trabeculectomy combined with collagen implant and mitomycin C compared to with mitomycin C alone in glaucoma: a retrospective cohort study |
| title_sort | efficacy of trabeculectomy combined with collagen implant and mitomycin c compared to with mitomycin c alone in glaucoma a retrospective cohort study |
| topic | ologen implant mitomycin c intraocular pressure glaucoma trabeculectomy |
| url | http://ies.ijo.cn/en_publish/2025/6/20250609.pdf |
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