Antitumor properties of nuclear erythroid cells
Purpose. To study suppressor and/or cytotoxic activity of the nuclear erythroid cells (NEC) against tumor cells of various origins. Material and Methods. C57Bl/6 mice and P815, L1210, B16 and L929 tumor cells were used. “Phenylhydrazine” NECs were obtained from mice with induced hemolytic anemia. “E...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Tomsk National Research Medical Center
2022-06-01
|
| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/2162 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849341255221248000 |
|---|---|
| author | V. A. Kozlov G. V. Seledtsova A. B. Dorzhieva I. P. Ivanova V. I. Seledtsov |
| author_facet | V. A. Kozlov G. V. Seledtsova A. B. Dorzhieva I. P. Ivanova V. I. Seledtsov |
| author_sort | V. A. Kozlov |
| collection | DOAJ |
| description | Purpose. To study suppressor and/or cytotoxic activity of the nuclear erythroid cells (NEC) against tumor cells of various origins. Material and Methods. C57Bl/6 mice and P815, L1210, B16 and L929 tumor cells were used. “Phenylhydrazine” NECs were obtained from mice with induced hemolytic anemia. “Erythropoietin” NECs were isolated from the “phenylhydrazine spleen” and further cultured in the presence of erythropoietin. Another source of NEC was neonatal mouse spleen, human and mouse fetal liver cells, and mouse bone marrow cells cultured with erythropoietin. The cytostatic effect of NEC or their supernatants was recorded by reducing proliferation of P815, L1210, B16, LLC, L929 lines. Results. The presence of pronounced direct antitumor activity was found in both NEC and their culturing products in relation to cells of various tumor lines. The suppressor effect was not specifc. Conclusion. We know about the signifcant numerical predominance of NEC during the embryo development over all other hematopoietic cells and their high suppressive potential. Therefore, it can be assumed that erythroblasts are involved in process of creating antitumor protection of a fetus during this period of life. |
| format | Article |
| id | doaj-art-fbf64402e3064216b5d2c4d4c2d9fa21 |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2022-06-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-fbf64402e3064216b5d2c4d4c2d9fa212025-08-20T03:43:40ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682022-06-01213424910.21294/1814-4861-2022-21-3-42-49997Antitumor properties of nuclear erythroid cellsV. A. Kozlov0G. V. Seledtsova1A. B. Dorzhieva2I. P. Ivanova3V. I. Seledtsov4Research Institute of Fundamental and Clinical ImmunologyResearch Institute of Fundamental and Clinical ImmunologyResearch Institute of Fundamental and Clinical ImmunologyResearch Institute of Fundamental and Clinical ImmunologyCentral Clinical Hospital of the Russian Academy of SciencesPurpose. To study suppressor and/or cytotoxic activity of the nuclear erythroid cells (NEC) against tumor cells of various origins. Material and Methods. C57Bl/6 mice and P815, L1210, B16 and L929 tumor cells were used. “Phenylhydrazine” NECs were obtained from mice with induced hemolytic anemia. “Erythropoietin” NECs were isolated from the “phenylhydrazine spleen” and further cultured in the presence of erythropoietin. Another source of NEC was neonatal mouse spleen, human and mouse fetal liver cells, and mouse bone marrow cells cultured with erythropoietin. The cytostatic effect of NEC or their supernatants was recorded by reducing proliferation of P815, L1210, B16, LLC, L929 lines. Results. The presence of pronounced direct antitumor activity was found in both NEC and their culturing products in relation to cells of various tumor lines. The suppressor effect was not specifc. Conclusion. We know about the signifcant numerical predominance of NEC during the embryo development over all other hematopoietic cells and their high suppressive potential. Therefore, it can be assumed that erythroblasts are involved in process of creating antitumor protection of a fetus during this period of life.https://www.siboncoj.ru/jour/article/view/2162nuclear erythroid cellserythroblastsantitumor activity |
| spellingShingle | V. A. Kozlov G. V. Seledtsova A. B. Dorzhieva I. P. Ivanova V. I. Seledtsov Antitumor properties of nuclear erythroid cells Сибирский онкологический журнал nuclear erythroid cells erythroblasts antitumor activity |
| title | Antitumor properties of nuclear erythroid cells |
| title_full | Antitumor properties of nuclear erythroid cells |
| title_fullStr | Antitumor properties of nuclear erythroid cells |
| title_full_unstemmed | Antitumor properties of nuclear erythroid cells |
| title_short | Antitumor properties of nuclear erythroid cells |
| title_sort | antitumor properties of nuclear erythroid cells |
| topic | nuclear erythroid cells erythroblasts antitumor activity |
| url | https://www.siboncoj.ru/jour/article/view/2162 |
| work_keys_str_mv | AT vakozlov antitumorpropertiesofnuclearerythroidcells AT gvseledtsova antitumorpropertiesofnuclearerythroidcells AT abdorzhieva antitumorpropertiesofnuclearerythroidcells AT ipivanova antitumorpropertiesofnuclearerythroidcells AT viseledtsov antitumorpropertiesofnuclearerythroidcells |