Fresh versus frozen micro-TESE sperm and outcomes
The use of fresh versus frozen spermatozoa in men with nonobstructive azoospermia (NOA) undergoing in vitro fertilization (IVF) has been a debated hot topic among reproductive specialists. Each approach presents distinct advantages and disadvantages, with fresh sperm typically showing superior sperm...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Asian Journal of Andrology |
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| Online Access: | https://journals.lww.com/10.4103/aja202513 |
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| author | Krishna Chaitanya Mantravadi Marlon Martinez Favian Ariiq Rahmat Armand Achmadsyah Missy Savira Ponco Birowo |
| author_facet | Krishna Chaitanya Mantravadi Marlon Martinez Favian Ariiq Rahmat Armand Achmadsyah Missy Savira Ponco Birowo |
| author_sort | Krishna Chaitanya Mantravadi |
| collection | DOAJ |
| description | The use of fresh versus frozen spermatozoa in men with nonobstructive azoospermia (NOA) undergoing in vitro fertilization (IVF) has been a debated hot topic among reproductive specialists. Each approach presents distinct advantages and disadvantages, with fresh sperm typically showing superior sperm quality, while frozen sperm offers logistical flexibility and a reliable backup for repeated cycles. This review summarizes the latest advancements in sperm retrieval and cryopreservation techniques, providing practitioners with a comprehensive analysis of each option’s strengths and limitations. Comparative studies indicate that, although fresh sperm often has better quality metrics, cryopreservation methods such as vitrification have significantly improved postthaw outcomes, making frozen sperm a viable choice in assisted reproductive technologies (ART). The findings show comparable rates for fertilization, implantation, clinical pregnancy, and live birth between fresh and frozen microdissection testicular sperm extraction (micro-TESE) sperm in many cases, although patient-specific factors such as timing, cost-effectiveness, and procedural convenience should guide the final decision. Ultimately, the choice of using fresh or frozen sperm should align with the individual needs and conditions of patients. This tailored approach, supported by the latest advancements, can optimize ART outcomes and provide personalized reproductive care. |
| format | Article |
| id | doaj-art-fbef3cd6a6b641058c03f2cb94f20a5e |
| institution | DOAJ |
| issn | 1008-682X 1745-7262 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj-art-fbef3cd6a6b641058c03f2cb94f20a5e2025-08-20T03:07:41ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622025-05-0127339940810.4103/aja202513Fresh versus frozen micro-TESE sperm and outcomesKrishna Chaitanya MantravadiMarlon MartinezFavian Ariiq RahmatArmand AchmadsyahMissy SaviraPonco BirowoThe use of fresh versus frozen spermatozoa in men with nonobstructive azoospermia (NOA) undergoing in vitro fertilization (IVF) has been a debated hot topic among reproductive specialists. Each approach presents distinct advantages and disadvantages, with fresh sperm typically showing superior sperm quality, while frozen sperm offers logistical flexibility and a reliable backup for repeated cycles. This review summarizes the latest advancements in sperm retrieval and cryopreservation techniques, providing practitioners with a comprehensive analysis of each option’s strengths and limitations. Comparative studies indicate that, although fresh sperm often has better quality metrics, cryopreservation methods such as vitrification have significantly improved postthaw outcomes, making frozen sperm a viable choice in assisted reproductive technologies (ART). The findings show comparable rates for fertilization, implantation, clinical pregnancy, and live birth between fresh and frozen microdissection testicular sperm extraction (micro-TESE) sperm in many cases, although patient-specific factors such as timing, cost-effectiveness, and procedural convenience should guide the final decision. Ultimately, the choice of using fresh or frozen sperm should align with the individual needs and conditions of patients. This tailored approach, supported by the latest advancements, can optimize ART outcomes and provide personalized reproductive care.https://journals.lww.com/10.4103/aja202513cryopreservationinfertilitymicrodissection testicular sperm extractionnonobstructive azoospermiaspermatozoa |
| spellingShingle | Krishna Chaitanya Mantravadi Marlon Martinez Favian Ariiq Rahmat Armand Achmadsyah Missy Savira Ponco Birowo Fresh versus frozen micro-TESE sperm and outcomes Asian Journal of Andrology cryopreservation infertility microdissection testicular sperm extraction nonobstructive azoospermia spermatozoa |
| title | Fresh versus frozen micro-TESE sperm and outcomes |
| title_full | Fresh versus frozen micro-TESE sperm and outcomes |
| title_fullStr | Fresh versus frozen micro-TESE sperm and outcomes |
| title_full_unstemmed | Fresh versus frozen micro-TESE sperm and outcomes |
| title_short | Fresh versus frozen micro-TESE sperm and outcomes |
| title_sort | fresh versus frozen micro tese sperm and outcomes |
| topic | cryopreservation infertility microdissection testicular sperm extraction nonobstructive azoospermia spermatozoa |
| url | https://journals.lww.com/10.4103/aja202513 |
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