Low-Grade Systemic Inflammation Profile, Unrelated to Homocysteinemia, in Obese Children

To investigate in prepubertal obese children (POC) the profile of chronic low-grade systemic inflammation (CLGSI) and its relation to homocysteinemia, 72 POC were evaluated for serum C-reactive protein (CRP) and amyloid A (SAA) levels, both markers of CLGSI, and plasma levels of total homocysteine (...

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Main Authors: Emanuel V. Economou, Ariadne V. Malamitsi-Puchner, Christos P. Pitsavos, Evangelia E. Kouskouni, Ioanna Magaziotou-Elefsinioti, George Creatsas
Format: Article
Language:English
Published: Wiley 2005-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/MI.2005.337
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author Emanuel V. Economou
Ariadne V. Malamitsi-Puchner
Christos P. Pitsavos
Evangelia E. Kouskouni
Ioanna Magaziotou-Elefsinioti
George Creatsas
author_facet Emanuel V. Economou
Ariadne V. Malamitsi-Puchner
Christos P. Pitsavos
Evangelia E. Kouskouni
Ioanna Magaziotou-Elefsinioti
George Creatsas
author_sort Emanuel V. Economou
collection DOAJ
description To investigate in prepubertal obese children (POC) the profile of chronic low-grade systemic inflammation (CLGSI) and its relation to homocysteinemia, 72 POC were evaluated for serum C-reactive protein (CRP) and amyloid A (SAA) levels, both markers of CLGSI, and plasma levels of total homocysteine (tHcy), an independent risk factor for adult atherosclerosis, in comparison to 42 prepubertal lean children (PLC). The main observations in POC were higher CRP levels compared to PLC, positive association of SAA levels to CRP levels, no association of CRP or SAA levels to tHcy levels. Thus, in POC, positively interrelated to each other, elevated CRP and unaltered SAA levels reveal a unique profile of the CLGSI, not explaining homocysteinemia-induced risk for future atherosclerosis.
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institution Kabale University
issn 0962-9351
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language English
publishDate 2005-01-01
publisher Wiley
record_format Article
series Mediators of Inflammation
spelling doaj-art-fbe7e7da91e3450a81f46b77c7b0e0ce2025-02-03T01:12:16ZengWileyMediators of Inflammation0962-93511466-18612005-01-012005633734210.1155/MI.2005.337Low-Grade Systemic Inflammation Profile, Unrelated to Homocysteinemia, in Obese ChildrenEmanuel V. Economou0Ariadne V. Malamitsi-Puchner1Christos P. Pitsavos2Evangelia E. Kouskouni3Ioanna Magaziotou-Elefsinioti4George Creatsas5Hormone Laboratory, 2nd Clinic for Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Athens 11528, GreeceDivision of Neonatology, 2nd Clinic for Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Athens 11528, GreeceDepartment of Cardiology, Hippokration Hospital, University of Athens, Athens 11527, GreeceHormone Laboratory, 2nd Clinic for Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Athens 11528, GreeceDepartment of Pediatrics, Tzaneion Hospital, Pireaus 18536, Greece2nd Clinic for Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Athens 11528, GreeceTo investigate in prepubertal obese children (POC) the profile of chronic low-grade systemic inflammation (CLGSI) and its relation to homocysteinemia, 72 POC were evaluated for serum C-reactive protein (CRP) and amyloid A (SAA) levels, both markers of CLGSI, and plasma levels of total homocysteine (tHcy), an independent risk factor for adult atherosclerosis, in comparison to 42 prepubertal lean children (PLC). The main observations in POC were higher CRP levels compared to PLC, positive association of SAA levels to CRP levels, no association of CRP or SAA levels to tHcy levels. Thus, in POC, positively interrelated to each other, elevated CRP and unaltered SAA levels reveal a unique profile of the CLGSI, not explaining homocysteinemia-induced risk for future atherosclerosis.http://dx.doi.org/10.1155/MI.2005.337
spellingShingle Emanuel V. Economou
Ariadne V. Malamitsi-Puchner
Christos P. Pitsavos
Evangelia E. Kouskouni
Ioanna Magaziotou-Elefsinioti
George Creatsas
Low-Grade Systemic Inflammation Profile, Unrelated to Homocysteinemia, in Obese Children
Mediators of Inflammation
title Low-Grade Systemic Inflammation Profile, Unrelated to Homocysteinemia, in Obese Children
title_full Low-Grade Systemic Inflammation Profile, Unrelated to Homocysteinemia, in Obese Children
title_fullStr Low-Grade Systemic Inflammation Profile, Unrelated to Homocysteinemia, in Obese Children
title_full_unstemmed Low-Grade Systemic Inflammation Profile, Unrelated to Homocysteinemia, in Obese Children
title_short Low-Grade Systemic Inflammation Profile, Unrelated to Homocysteinemia, in Obese Children
title_sort low grade systemic inflammation profile unrelated to homocysteinemia in obese children
url http://dx.doi.org/10.1155/MI.2005.337
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