Low-Grade Systemic Inflammation Profile, Unrelated to Homocysteinemia, in Obese Children
To investigate in prepubertal obese children (POC) the profile of chronic low-grade systemic inflammation (CLGSI) and its relation to homocysteinemia, 72 POC were evaluated for serum C-reactive protein (CRP) and amyloid A (SAA) levels, both markers of CLGSI, and plasma levels of total homocysteine (...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2005-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI.2005.337 |
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| Summary: | To investigate in prepubertal obese children (POC) the
profile of chronic low-grade systemic inflammation (CLGSI) and
its relation to homocysteinemia, 72 POC were evaluated for serum
C-reactive protein (CRP) and amyloid A (SAA) levels, both markers
of CLGSI, and plasma levels of total homocysteine (tHcy), an
independent risk factor for adult atherosclerosis, in comparison
to 42 prepubertal lean children (PLC). The main observations in
POC were higher CRP levels compared to PLC, positive association
of SAA levels to CRP levels, no association of CRP or SAA levels
to tHcy levels. Thus, in POC, positively interrelated to each
other, elevated CRP and unaltered SAA levels reveal a unique
profile of the CLGSI, not explaining homocysteinemia-induced risk
for future atherosclerosis. |
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| ISSN: | 0962-9351 1466-1861 |