Effectiveness of islatravir post‐exposure prophylaxis after intravenous challenge with simian immunodeficiency virus in rhesus macaques

Effectiveness of islatravir post‐exposure prophylaxis after intravenous challenge with simian immunodeficiency virus in rhesus macaques

Abstract Introduction Islatravir (ISL) is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) with robust antiretroviral activity. The efficacy of ISL administered for post‐exposure prophylaxis (PEP) was evaluated in a simian immunodeficiency virus (SIV) rhesus macaque intravenous (IV...

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Main Authors: Martin Markowitz, Agegnehu Gettie, Leslie St. Bernard, Brooke Grasperge, Ryan Vargo, Michelle Pham, Kerry Fillgrove, Neal Dube, Tracy L. Diamond, Daria J. Hazuda, Jay A. Grobler
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Journal of the International AIDS Society
Subjects:
islatravir
post‐exposure prophylaxis
rhesus macaque
SIV
pharmacokinetic
islatravir‐TP
Online Access:https://doi.org/10.1002/jia2.26507
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