A Rare Cutaneous Malignancy: A Primary Cutaneous Carcinosarcoma with Adnexal Epithelial Component (Trichoblastic Carcinosarcoma) of Left Temporal Region
Primary cutaneous carcinosarcoma (PCCS) is a rare cutaneous biphasic tumour with just 120 cases being reported till date. The epithelial component trichoblastic carcinoma/ malignant trichoblastoma (trichoblastic carcinosarcoma) is even rarer, so is the present case. An eighty years old male patient...
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Indian Journal of Dermatology |
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| Online Access: | https://journals.lww.com/10.4103/ijd.ijd_243_23 |
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| author | Vaishali B. Nagose Sachin S. Ingle Nilesh O. Chandak Shirish R. Gondane |
| author_facet | Vaishali B. Nagose Sachin S. Ingle Nilesh O. Chandak Shirish R. Gondane |
| author_sort | Vaishali B. Nagose |
| collection | DOAJ |
| description | Primary cutaneous carcinosarcoma (PCCS) is a rare cutaneous biphasic tumour with just 120 cases being reported till date. The epithelial component trichoblastic carcinoma/ malignant trichoblastoma (trichoblastic carcinosarcoma) is even rarer, so is the present case. An eighty years old male patient presented with a rapidly progressing ulceroproliferative nodular growth on the left temporal region. The incisional biopsy showed primary cutaneous carcinomasarcoma (PCCS). IHC showed epithelial and stromal component marked exclusively for pancytokeratin (AE1/AE3) CK5&6/ p40 and vimentin respectively. Both components were immunopositive for D2-40 and immunonegative for BerEP4/ S100/ Melan A/ MITF, thus final diagnosis given was Trichoblastic carcinosarcoma. Wide excision of the lesion with local rotation flap and skin grafting (thigh skin) was done. Patient remains disease free after four years also. Present case thus highlights the importance of HPE, IHC and early surgery for excellent prognosis of PCCS. |
| format | Article |
| id | doaj-art-fbe65d946faf47858909784955fcd8f8 |
| institution | Kabale University |
| issn | 0019-5154 1998-3611 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj-art-fbe65d946faf47858909784955fcd8f82025-01-20T10:33:43ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112024-01-01691778010.4103/ijd.ijd_243_23A Rare Cutaneous Malignancy: A Primary Cutaneous Carcinosarcoma with Adnexal Epithelial Component (Trichoblastic Carcinosarcoma) of Left Temporal RegionVaishali B. NagoseSachin S. IngleNilesh O. ChandakShirish R. GondanePrimary cutaneous carcinosarcoma (PCCS) is a rare cutaneous biphasic tumour with just 120 cases being reported till date. The epithelial component trichoblastic carcinoma/ malignant trichoblastoma (trichoblastic carcinosarcoma) is even rarer, so is the present case. An eighty years old male patient presented with a rapidly progressing ulceroproliferative nodular growth on the left temporal region. The incisional biopsy showed primary cutaneous carcinomasarcoma (PCCS). IHC showed epithelial and stromal component marked exclusively for pancytokeratin (AE1/AE3) CK5&6/ p40 and vimentin respectively. Both components were immunopositive for D2-40 and immunonegative for BerEP4/ S100/ Melan A/ MITF, thus final diagnosis given was Trichoblastic carcinosarcoma. Wide excision of the lesion with local rotation flap and skin grafting (thigh skin) was done. Patient remains disease free after four years also. Present case thus highlights the importance of HPE, IHC and early surgery for excellent prognosis of PCCS.https://journals.lww.com/10.4103/ijd.ijd_243_23adnexal and skin appendagecarcinomacarcinosarcomametaplastic carcinomaneoplasmsskin appendageskin cancer |
| spellingShingle | Vaishali B. Nagose Sachin S. Ingle Nilesh O. Chandak Shirish R. Gondane A Rare Cutaneous Malignancy: A Primary Cutaneous Carcinosarcoma with Adnexal Epithelial Component (Trichoblastic Carcinosarcoma) of Left Temporal Region Indian Journal of Dermatology adnexal and skin appendage carcinoma carcinosarcoma metaplastic carcinoma neoplasms skin appendage skin cancer |
| title | A Rare Cutaneous Malignancy: A Primary Cutaneous Carcinosarcoma with Adnexal Epithelial Component (Trichoblastic Carcinosarcoma) of Left Temporal Region |
| title_full | A Rare Cutaneous Malignancy: A Primary Cutaneous Carcinosarcoma with Adnexal Epithelial Component (Trichoblastic Carcinosarcoma) of Left Temporal Region |
| title_fullStr | A Rare Cutaneous Malignancy: A Primary Cutaneous Carcinosarcoma with Adnexal Epithelial Component (Trichoblastic Carcinosarcoma) of Left Temporal Region |
| title_full_unstemmed | A Rare Cutaneous Malignancy: A Primary Cutaneous Carcinosarcoma with Adnexal Epithelial Component (Trichoblastic Carcinosarcoma) of Left Temporal Region |
| title_short | A Rare Cutaneous Malignancy: A Primary Cutaneous Carcinosarcoma with Adnexal Epithelial Component (Trichoblastic Carcinosarcoma) of Left Temporal Region |
| title_sort | rare cutaneous malignancy a primary cutaneous carcinosarcoma with adnexal epithelial component trichoblastic carcinosarcoma of left temporal region |
| topic | adnexal and skin appendage carcinoma carcinosarcoma metaplastic carcinoma neoplasms skin appendage skin cancer |
| url | https://journals.lww.com/10.4103/ijd.ijd_243_23 |
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