A non-linear association between AST/ALT ratio and 28-day mortality in critically ill elderly: evidence from a multicenter study

A non-linear association between AST/ALT ratio and 28-day mortality in critically ill elderly: evidence from a multicenter study

Abstract With the global aging population, the proportion of elderly patients in ICU continues to rise. The ratio of aspartate aminotransferase to alanine aminotransferase (AST/ALT) has been linked to unfavorable outcomes in several diseases, but its value in critically ill elderly patients remains...

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Bibliographic Details
Main Authors: Ling Wang, Ping Jin, Yanping Hui, Libo Li, Yixuan Wang, Xiang Wu, Yihua Bai, Lei Lu, Hongfei Qiao, Qiaojun Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
AST/ALT ratio
Critically ill elderly patients
Mortality
WBC
Mediation effect
Online Access:https://doi.org/10.1038/s41598-025-11220-6
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