Enhancing the Photocatalytic Efficacy of g-C<sub>3</sub>N<sub>4</sub> Through Irradiation Modification and Composite Construction with Ti<sub>3</sub>C<sub>2</sub> for Photodynamic Therapy

Enhancing the Photocatalytic Efficacy of g-C<sub>3</sub>N<sub>4</sub> Through Irradiation Modification and Composite Construction with Ti<sub>3</sub>C<sub>2</sub> for Photodynamic Therapy

Photodynamic therapy (PDT) holds considerable promise for advancing anticancer treatment, owing to its precision and minimally invasive nature. In this study, we successfully synthesized a series of titanium carbide (Ti<sub>3</sub>C<sub>2</sub>, TC)/graphitic carbon nitride (...

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Bibliographic Details
Main Authors: Bin Huang, Yilun Wang, Xuguang Chen, Yue Wu, Kaidi Xu, Simeng Xie, Ziyang Qin, Xiang Liu, Huangqin Chen, Yuesheng Li
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
titanium carbide
graphitic carbon nitride
electron beam irradiation
photodynamic therapy
Online Access:https://www.mdpi.com/1420-3049/30/3/487
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Summary:Photodynamic therapy (PDT) holds considerable promise for advancing anticancer treatment, owing to its precision and minimally invasive nature. In this study, we successfully synthesized a series of titanium carbide (Ti<sub>3</sub>C<sub>2</sub>, TC)/graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>, CN) nanocomposite through a synergistic approach combining electron beam irradiation and 2D/2D composite formation. According to the results, 1TC/200-CN (1TC, which TC was 1, referred to the mass ratio; 200-CN, which CN was 200 kGy, referred to the irradiation metering) displayed a 94% degradation rate of methylene blue (10 mg/L) in 100 min. Furthermore, the proliferation rate of CAL-27 cells was suppressed to just 23.3% at a concentration of 320 μg/mL of 1TC/200-CN. Notably, the group treated with this concentration exhibited the largest residual scratch area, accompanied by a notable decrease in mitochondrial membrane potential. These enhanced effects were attributed to the efficient transfer of electron-hole pairs facilitated by the TC/CN composite. Our findings not only contribute to the development of efficient and stable nanocomposites for PDT applications but also provide valuable insights into the utilization of nanomaterials in the biomedical field, thereby paving the way for potential breakthroughs in cancer treatment.
ISSN:1420-3049

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