Piezoelectric Nanomaterials for Cancer Therapy: Current Research and Future Perspectives on Glioblastoma
Cancer significantly impacts human quality of life and life expectancy, with an estimated 20 million new cases and 10 million cancer-related deaths worldwide every year. Standard treatments including chemotherapy, radiotherapy, and surgical removal, for aggressive cancers, such as glioblastoma, are...
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MDPI AG
2025-03-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/16/4/114 |
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| author | Zayne Knight Amalia Ruiz Jacobo Elies |
| author_facet | Zayne Knight Amalia Ruiz Jacobo Elies |
| author_sort | Zayne Knight |
| collection | DOAJ |
| description | Cancer significantly impacts human quality of life and life expectancy, with an estimated 20 million new cases and 10 million cancer-related deaths worldwide every year. Standard treatments including chemotherapy, radiotherapy, and surgical removal, for aggressive cancers, such as glioblastoma, are often ineffective in late stages. Glioblastoma, for example, is known for its poor prognosis post-diagnosis, with a median survival time of approximately 15 months. Novel therapies using local electric fields have shown anti-tumour effects in glioblastoma by disrupting mitotic spindle assembly and inhibiting cell growth. However, constant application poses risks like patient burns. Wireless stimulation via piezoelectric nanomaterials offers a safer alternative, requiring ultrasound activation to induce therapeutic effects, such as altering voltage-gated ion channel conductance by depolarising membrane potentials. This review highlights the piezoelectric mechanism, drug delivery, ion channel activation, and current technologies in cancer therapy, emphasising the need for further research to address limitations like biocompatibility in whole systems. The goal is to underscore these areas to inspire new avenues of research and overcome barriers to developing piezoelectric nanoparticle-based cancer therapies. |
| format | Article |
| id | doaj-art-fbde197e6b0f48b0be32c3d09a380d12 |
| institution | DOAJ |
| issn | 2079-4983 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj-art-fbde197e6b0f48b0be32c3d09a380d122025-08-20T03:13:58ZengMDPI AGJournal of Functional Biomaterials2079-49832025-03-0116411410.3390/jfb16040114Piezoelectric Nanomaterials for Cancer Therapy: Current Research and Future Perspectives on GlioblastomaZayne Knight0Amalia Ruiz1Jacobo Elies2Centre for Pharmaceutical Engineering Science, School of Pharmacy, University of Bradford, Bradford BD7 1DP, UKInstitute of Cancer Therapeutics (ICT), Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UKInstitute of Cancer Therapeutics (ICT), Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UKCancer significantly impacts human quality of life and life expectancy, with an estimated 20 million new cases and 10 million cancer-related deaths worldwide every year. Standard treatments including chemotherapy, radiotherapy, and surgical removal, for aggressive cancers, such as glioblastoma, are often ineffective in late stages. Glioblastoma, for example, is known for its poor prognosis post-diagnosis, with a median survival time of approximately 15 months. Novel therapies using local electric fields have shown anti-tumour effects in glioblastoma by disrupting mitotic spindle assembly and inhibiting cell growth. However, constant application poses risks like patient burns. Wireless stimulation via piezoelectric nanomaterials offers a safer alternative, requiring ultrasound activation to induce therapeutic effects, such as altering voltage-gated ion channel conductance by depolarising membrane potentials. This review highlights the piezoelectric mechanism, drug delivery, ion channel activation, and current technologies in cancer therapy, emphasising the need for further research to address limitations like biocompatibility in whole systems. The goal is to underscore these areas to inspire new avenues of research and overcome barriers to developing piezoelectric nanoparticle-based cancer therapies.https://www.mdpi.com/2079-4983/16/4/114piezoelectric nanomaterialscancer therapyglioblastomavoltage-gated ion channelsPiezo channels |
| spellingShingle | Zayne Knight Amalia Ruiz Jacobo Elies Piezoelectric Nanomaterials for Cancer Therapy: Current Research and Future Perspectives on Glioblastoma Journal of Functional Biomaterials piezoelectric nanomaterials cancer therapy glioblastoma voltage-gated ion channels Piezo channels |
| title | Piezoelectric Nanomaterials for Cancer Therapy: Current Research and Future Perspectives on Glioblastoma |
| title_full | Piezoelectric Nanomaterials for Cancer Therapy: Current Research and Future Perspectives on Glioblastoma |
| title_fullStr | Piezoelectric Nanomaterials for Cancer Therapy: Current Research and Future Perspectives on Glioblastoma |
| title_full_unstemmed | Piezoelectric Nanomaterials for Cancer Therapy: Current Research and Future Perspectives on Glioblastoma |
| title_short | Piezoelectric Nanomaterials for Cancer Therapy: Current Research and Future Perspectives on Glioblastoma |
| title_sort | piezoelectric nanomaterials for cancer therapy current research and future perspectives on glioblastoma |
| topic | piezoelectric nanomaterials cancer therapy glioblastoma voltage-gated ion channels Piezo channels |
| url | https://www.mdpi.com/2079-4983/16/4/114 |
| work_keys_str_mv | AT zayneknight piezoelectricnanomaterialsforcancertherapycurrentresearchandfutureperspectivesonglioblastoma AT amaliaruiz piezoelectricnanomaterialsforcancertherapycurrentresearchandfutureperspectivesonglioblastoma AT jacoboelies piezoelectricnanomaterialsforcancertherapycurrentresearchandfutureperspectivesonglioblastoma |