Research progress and development potential of oncolytic vaccinia virus
Abstract. Oncolytic virotherapy is a promising therapeutic approach treating tumors, where oncolytic viruses (OVs) can selectively infect and lyse tumor cells through replication, while also triggering long-lasting anti-tumor immune responses. Vaccinia virus (VV) has emerged as a leading candidate f...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2025-04-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000003585 |
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| _version_ | 1849701485374341120 |
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| author | Xinyu Zhang Jiangshan He Yiming Shao Sihan Zhou Xiuyuan Hao |
| author_facet | Xinyu Zhang Jiangshan He Yiming Shao Sihan Zhou Xiuyuan Hao |
| author_sort | Xinyu Zhang |
| collection | DOAJ |
| description | Abstract. Oncolytic virotherapy is a promising therapeutic approach treating tumors, where oncolytic viruses (OVs) can selectively infect and lyse tumor cells through replication, while also triggering long-lasting anti-tumor immune responses. Vaccinia virus (VV) has emerged as a leading candidate for use as an OV due to its broad cytophilicity and robust capacity to express exogenous genes. Consequently, oncolytic vaccinia virus (OVV) has entered clinical trials. This review provides an overview of the key strategies used in the development of OVV, summarizes the findings from clinical trials, and addresses the challenges that must be overcome in the advancement of OVV-based therapies. Furthermore, it explores potential future strategies for enhancing the development and clinical application of OVV, intending to improve tumor treatment outcomes. The review aims to facilitate the further development and clinical adoption of OVV, thereby advancing tumor therapies. |
| format | Article |
| id | doaj-art-fbd2b9b4fa7f4e25ab1e8479f911c409 |
| institution | DOAJ |
| issn | 0366-6999 2542-5641 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj-art-fbd2b9b4fa7f4e25ab1e8479f911c4092025-08-20T03:17:55ZengWolters KluwerChinese Medical Journal0366-69992542-56412025-04-01138777779110.1097/CM9.0000000000003585202504050-00003Research progress and development potential of oncolytic vaccinia virusXinyu Zhang0Jiangshan He1Yiming Shao2Sihan ZhouXiuyuan Hao1 Changping Laboratory, Beijing 102206, China1 Changping Laboratory, Beijing 102206, China1 Changping Laboratory, Beijing 102206, ChinaAbstract. Oncolytic virotherapy is a promising therapeutic approach treating tumors, where oncolytic viruses (OVs) can selectively infect and lyse tumor cells through replication, while also triggering long-lasting anti-tumor immune responses. Vaccinia virus (VV) has emerged as a leading candidate for use as an OV due to its broad cytophilicity and robust capacity to express exogenous genes. Consequently, oncolytic vaccinia virus (OVV) has entered clinical trials. This review provides an overview of the key strategies used in the development of OVV, summarizes the findings from clinical trials, and addresses the challenges that must be overcome in the advancement of OVV-based therapies. Furthermore, it explores potential future strategies for enhancing the development and clinical application of OVV, intending to improve tumor treatment outcomes. The review aims to facilitate the further development and clinical adoption of OVV, thereby advancing tumor therapies.http://journals.lww.com/10.1097/CM9.0000000000003585 |
| spellingShingle | Xinyu Zhang Jiangshan He Yiming Shao Sihan Zhou Xiuyuan Hao Research progress and development potential of oncolytic vaccinia virus Chinese Medical Journal |
| title | Research progress and development potential of oncolytic vaccinia virus |
| title_full | Research progress and development potential of oncolytic vaccinia virus |
| title_fullStr | Research progress and development potential of oncolytic vaccinia virus |
| title_full_unstemmed | Research progress and development potential of oncolytic vaccinia virus |
| title_short | Research progress and development potential of oncolytic vaccinia virus |
| title_sort | research progress and development potential of oncolytic vaccinia virus |
| url | http://journals.lww.com/10.1097/CM9.0000000000003585 |
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