Investigation of Adenosine deamidase (ADA) activity and some biochemical values in lambs with infectious ecthyma symptoms
ABSTRACT Understanding the zoonotic risk posed by the orf virus (ORFV), which causes contagious ecthyma in domestic animals, is crucial for both human and animal health. Contagious ecthyma is a highly contagious, zoonotic, viral skin disease that affects sheep, goats, and certain other domestic and...
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Universidade Federal de Minas Gerais
2025-07-01
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| Series: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
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| author | S. Kızıltepe C. Okulmus R. Akpınar O. Merhan K. Bozukluhan N. Coşkun |
| author_facet | S. Kızıltepe C. Okulmus R. Akpınar O. Merhan K. Bozukluhan N. Coşkun |
| author_sort | S. Kızıltepe |
| collection | DOAJ |
| description | ABSTRACT Understanding the zoonotic risk posed by the orf virus (ORFV), which causes contagious ecthyma in domestic animals, is crucial for both human and animal health. Contagious ecthyma is a highly contagious, zoonotic, viral skin disease that affects sheep, goats, and certain other domestic and wild animals. In this study, serum malondialdehyde (MDA), nitric oxide (NO), reduced glutathione (GSH) concentrations, and adenosine deaminase (ADA) activity were measured in healthy and naturally infected lambs with ecthyma. Compared to healthy lambs, serum MDA (respectively; 2.69±0.4 vs. 4.73±0.24 μmol/L, P<0.001), NO (respectively; 6.12±0.72 vs. 8.32±0.55μmol/L, P<0.05) and ADA (respectively; 7.12±0.60 vs. 21.53±1.82 U/L, P<0.001) concentrations increased, while GSH (respectively; 15.01±1.59vs. 10.05±1.10mg/dL, P<0.05) levels decreased in contagious ecthyma lambs. As a result, it was concluded that oxidative stress developed in lambs infected with contagious ecthyma, ADA enzyme activity increased, and this could be useful for the diagnosis of the disease. |
| format | Article |
| id | doaj-art-fbcda5de0ea74a20bf1fb8155e7bdaec |
| institution | Kabale University |
| issn | 1678-4162 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Universidade Federal de Minas Gerais |
| record_format | Article |
| series | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
| spelling | doaj-art-fbcda5de0ea74a20bf1fb8155e7bdaec2025-08-20T03:25:22ZengUniversidade Federal de Minas GeraisArquivo Brasileiro de Medicina Veterinária e Zootecnia1678-41622025-07-0177410.1590/1678-4162-13399Investigation of Adenosine deamidase (ADA) activity and some biochemical values in lambs with infectious ecthyma symptomsS. Kızıltepehttps://orcid.org/0000-0003-3727-8893C. Okulmushttps://orcid.org/0000-0003-3563-3716R. Akpınarhttps://orcid.org/0000-0003-0075-9247O. Merhanhttps://orcid.org/0000-0002-3399-0667K. Bozukluhanhttps://orcid.org/0000-0003-4929-5156N. Coşkunhttps://orcid.org/0000-0001-7642-6460ABSTRACT Understanding the zoonotic risk posed by the orf virus (ORFV), which causes contagious ecthyma in domestic animals, is crucial for both human and animal health. Contagious ecthyma is a highly contagious, zoonotic, viral skin disease that affects sheep, goats, and certain other domestic and wild animals. In this study, serum malondialdehyde (MDA), nitric oxide (NO), reduced glutathione (GSH) concentrations, and adenosine deaminase (ADA) activity were measured in healthy and naturally infected lambs with ecthyma. Compared to healthy lambs, serum MDA (respectively; 2.69±0.4 vs. 4.73±0.24 μmol/L, P<0.001), NO (respectively; 6.12±0.72 vs. 8.32±0.55μmol/L, P<0.05) and ADA (respectively; 7.12±0.60 vs. 21.53±1.82 U/L, P<0.001) concentrations increased, while GSH (respectively; 15.01±1.59vs. 10.05±1.10mg/dL, P<0.05) levels decreased in contagious ecthyma lambs. As a result, it was concluded that oxidative stress developed in lambs infected with contagious ecthyma, ADA enzyme activity increased, and this could be useful for the diagnosis of the disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352025000400115&lng=en&tlng=enAdenosine deaminaseecthymalamboxidative stress |
| spellingShingle | S. Kızıltepe C. Okulmus R. Akpınar O. Merhan K. Bozukluhan N. Coşkun Investigation of Adenosine deamidase (ADA) activity and some biochemical values in lambs with infectious ecthyma symptoms Arquivo Brasileiro de Medicina Veterinária e Zootecnia Adenosine deaminase ecthyma lamb oxidative stress |
| title | Investigation of Adenosine deamidase (ADA) activity and some biochemical values in lambs with infectious ecthyma symptoms |
| title_full | Investigation of Adenosine deamidase (ADA) activity and some biochemical values in lambs with infectious ecthyma symptoms |
| title_fullStr | Investigation of Adenosine deamidase (ADA) activity and some biochemical values in lambs with infectious ecthyma symptoms |
| title_full_unstemmed | Investigation of Adenosine deamidase (ADA) activity and some biochemical values in lambs with infectious ecthyma symptoms |
| title_short | Investigation of Adenosine deamidase (ADA) activity and some biochemical values in lambs with infectious ecthyma symptoms |
| title_sort | investigation of adenosine deamidase ada activity and some biochemical values in lambs with infectious ecthyma symptoms |
| topic | Adenosine deaminase ecthyma lamb oxidative stress |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352025000400115&lng=en&tlng=en |
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