Risk factors for early wheezing in preterm infants: a retrospective cohort study
IntroductionThe related factors that cause recurrent wheezing in children are complex, and premature delivery may be one of the reasons. Little is known about early wheezing in preterm infants.MethodsData sourced from 1,616 children born between 2007 and 2013 from 8 hospitals of Guangxi in China. Al...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1555834/full |
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| author | Xun Chen Minjing Yang Jun Xie Shengzhu Huang Xiaolian Qin Zhijian Pan Maoling Zhu Dingyuan Zeng Yifeng Huang Tao Liang Chunmei Liang Guangmin Nong |
| author_facet | Xun Chen Minjing Yang Jun Xie Shengzhu Huang Xiaolian Qin Zhijian Pan Maoling Zhu Dingyuan Zeng Yifeng Huang Tao Liang Chunmei Liang Guangmin Nong |
| author_sort | Xun Chen |
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| description | IntroductionThe related factors that cause recurrent wheezing in children are complex, and premature delivery may be one of the reasons. Little is known about early wheezing in preterm infants.MethodsData sourced from 1,616 children born between 2007 and 2013 from 8 hospitals of Guangxi in China. All children were followed by telephone or questionnaire through the sixth year of life. Children were grouped by characters of age: Group A: gestational age (GA ≤ 32 weeks, Group B: 32 weeks < GA < 37 weeks, Group C: 37 weeks ≤ GA < 42 weeks.ResultsThe incidence and the risk factors of early wheezing in preterm infants were analyzed. The incidence of early wheezing: Group A > Group B > Group C. In Group A, the proportion of small-for-gestational-age (SGA) infant was higher in early wheezing group than in normal group (P < 0.05). Male (95% CI: 1.611–4.601) and family history of allergy (95% CI: 1.222–3.411) were the risk factors for early wheezing in Group B.ConclusionsLower gestational age is associated with higher wheezing risk. Preterm infants have higher persistent wheezing incidence than full-term infants. Preterm infants with gestational age <32 weeks have higher transient wheezing incidence than those with gestational age 32–37 weeks or full-term infants. In preterm infants <32 weeks, small for gestational age (SGA) is a potential factor for wheezing. In preterm infants aged 32–37 weeks, male sex, personal allergy history, and family allergy history are potential factors for wheezing, with male sex and family allergy history being significant risk factors. |
| format | Article |
| id | doaj-art-fbcca6bffa05441bbd70d824bb03b331 |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-fbcca6bffa05441bbd70d824bb03b3312025-08-20T03:24:16ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-06-011310.3389/fped.2025.15558341555834Risk factors for early wheezing in preterm infants: a retrospective cohort studyXun Chen0Minjing Yang1Jun Xie2Shengzhu Huang3Xiaolian Qin4Zhijian Pan5Maoling Zhu6Dingyuan Zeng7Yifeng Huang8Tao Liang9Chunmei Liang10Guangmin Nong11Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Student Affairs, Yulin Campus of Guangxi Medical UniversityYulin, Guangxi, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaCenter for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Medical Services Section, Maternal & Child Health Hospital of Yulin, Yulin, Guangxi, ChinaDepartment of Gynecology and Obstetrics, Maternal & Child Health Hospital of Qinzhou, Qinzhou, Guangxi, ChinaDepartment of Obstetrics, Maternal & Child Health Hospital of Nanning, Nanning, Guangxi, ChinaDepartment of Gynecology and Obstetrics, Maternal & Child Health Hospital of Liuzhou, Liuzhou, Guangxi, ChinaDepartment of Gynecology and Obstetrics, Maternal & Child Health Hospital of Guigang, Guigang, Guangxi, ChinaDepartment of Pediatrics, Maternal & Child Health Hospital of Wuzhou, Wuzhou, Guangxi, China0Department of Gynecology and Obstetrics, Maternal & Child Health Hospital of Yuzhou, Yulin, Guangxi, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaIntroductionThe related factors that cause recurrent wheezing in children are complex, and premature delivery may be one of the reasons. Little is known about early wheezing in preterm infants.MethodsData sourced from 1,616 children born between 2007 and 2013 from 8 hospitals of Guangxi in China. All children were followed by telephone or questionnaire through the sixth year of life. Children were grouped by characters of age: Group A: gestational age (GA ≤ 32 weeks, Group B: 32 weeks < GA < 37 weeks, Group C: 37 weeks ≤ GA < 42 weeks.ResultsThe incidence and the risk factors of early wheezing in preterm infants were analyzed. The incidence of early wheezing: Group A > Group B > Group C. In Group A, the proportion of small-for-gestational-age (SGA) infant was higher in early wheezing group than in normal group (P < 0.05). Male (95% CI: 1.611–4.601) and family history of allergy (95% CI: 1.222–3.411) were the risk factors for early wheezing in Group B.ConclusionsLower gestational age is associated with higher wheezing risk. Preterm infants have higher persistent wheezing incidence than full-term infants. Preterm infants with gestational age <32 weeks have higher transient wheezing incidence than those with gestational age 32–37 weeks or full-term infants. In preterm infants <32 weeks, small for gestational age (SGA) is a potential factor for wheezing. In preterm infants aged 32–37 weeks, male sex, personal allergy history, and family allergy history are potential factors for wheezing, with male sex and family allergy history being significant risk factors.https://www.frontiersin.org/articles/10.3389/fped.2025.1555834/fullwheezingpreterm infantsrisk factorsgestational ageallergy |
| spellingShingle | Xun Chen Minjing Yang Jun Xie Shengzhu Huang Xiaolian Qin Zhijian Pan Maoling Zhu Dingyuan Zeng Yifeng Huang Tao Liang Chunmei Liang Guangmin Nong Risk factors for early wheezing in preterm infants: a retrospective cohort study Frontiers in Pediatrics wheezing preterm infants risk factors gestational age allergy |
| title | Risk factors for early wheezing in preterm infants: a retrospective cohort study |
| title_full | Risk factors for early wheezing in preterm infants: a retrospective cohort study |
| title_fullStr | Risk factors for early wheezing in preterm infants: a retrospective cohort study |
| title_full_unstemmed | Risk factors for early wheezing in preterm infants: a retrospective cohort study |
| title_short | Risk factors for early wheezing in preterm infants: a retrospective cohort study |
| title_sort | risk factors for early wheezing in preterm infants a retrospective cohort study |
| topic | wheezing preterm infants risk factors gestational age allergy |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1555834/full |
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