Regenerative therapies for myocardial infarction: exploring the critical role of energy metabolism in achieving cardiac repair
Cardiovascular diseases are the most lethal diseases worldwide, of which myocardial infarction is the leading cause of death. After myocardial infarction, in order to ensure normal blood supply to the heart, the remaining cardiomyocytes compensate for the loss of cardiomyocytes mainly by working at...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1533105/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206763175018496 |
|---|---|
| author | Jiahao Ren Xinzhe Chen Tao Wang Cuiyun Liu Kun Wang |
| author_facet | Jiahao Ren Xinzhe Chen Tao Wang Cuiyun Liu Kun Wang |
| author_sort | Jiahao Ren |
| collection | DOAJ |
| description | Cardiovascular diseases are the most lethal diseases worldwide, of which myocardial infarction is the leading cause of death. After myocardial infarction, in order to ensure normal blood supply to the heart, the remaining cardiomyocytes compensate for the loss of cardiomyocytes mainly by working at high capacity rather than by proliferating to produce new cardiomyocytes. This is partly due to the extremely limited ability of the adult heart to repair itself. A growing body of research suggests that the loss of cardiac regenerative capacity is closely related to metabolic shifts in energy sources. Currently, a large number of studies have focused on changes in metabolic levels before and after the proliferation window of cardiomyocytes, so it is crucial to search for relevant factors in metabolic pathways to regulate the cell cycle in cardiomyocyte progression. This paper presents a review of the role of myocardial energy metabolism in regenerative repair after cardiac injury. It aims to elucidate the effects of myocardial metabolic shifts on cardiomyocyte proliferation in adult mammals and to point out directions for cardiac regeneration research and clinical treatment of myocardial infarction. |
| format | Article |
| id | doaj-art-fbc3be54871346528ec614231c4aea27 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-fbc3be54871346528ec614231c4aea272025-02-07T06:49:43ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-02-011210.3389/fcvm.2025.15331051533105Regenerative therapies for myocardial infarction: exploring the critical role of energy metabolism in achieving cardiac repairJiahao Ren0Xinzhe Chen1Tao Wang2Cuiyun Liu3Kun Wang4Key Laboratory of Maternal & Fetal Medicine of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, ChinaKey Laboratory of Maternal & Fetal Medicine of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, ChinaJinan Microecological Biomedicine Shandong Laboratory, Jinan, ChinaKey Laboratory of Maternal & Fetal Medicine of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, ChinaKey Laboratory of Maternal & Fetal Medicine of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, ChinaCardiovascular diseases are the most lethal diseases worldwide, of which myocardial infarction is the leading cause of death. After myocardial infarction, in order to ensure normal blood supply to the heart, the remaining cardiomyocytes compensate for the loss of cardiomyocytes mainly by working at high capacity rather than by proliferating to produce new cardiomyocytes. This is partly due to the extremely limited ability of the adult heart to repair itself. A growing body of research suggests that the loss of cardiac regenerative capacity is closely related to metabolic shifts in energy sources. Currently, a large number of studies have focused on changes in metabolic levels before and after the proliferation window of cardiomyocytes, so it is crucial to search for relevant factors in metabolic pathways to regulate the cell cycle in cardiomyocyte progression. This paper presents a review of the role of myocardial energy metabolism in regenerative repair after cardiac injury. It aims to elucidate the effects of myocardial metabolic shifts on cardiomyocyte proliferation in adult mammals and to point out directions for cardiac regeneration research and clinical treatment of myocardial infarction.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1533105/fullmyocardial infarctioncardiomyocyte proliferationcardiac regenerationenergy metabolismcell cycle |
| spellingShingle | Jiahao Ren Xinzhe Chen Tao Wang Cuiyun Liu Kun Wang Regenerative therapies for myocardial infarction: exploring the critical role of energy metabolism in achieving cardiac repair Frontiers in Cardiovascular Medicine myocardial infarction cardiomyocyte proliferation cardiac regeneration energy metabolism cell cycle |
| title | Regenerative therapies for myocardial infarction: exploring the critical role of energy metabolism in achieving cardiac repair |
| title_full | Regenerative therapies for myocardial infarction: exploring the critical role of energy metabolism in achieving cardiac repair |
| title_fullStr | Regenerative therapies for myocardial infarction: exploring the critical role of energy metabolism in achieving cardiac repair |
| title_full_unstemmed | Regenerative therapies for myocardial infarction: exploring the critical role of energy metabolism in achieving cardiac repair |
| title_short | Regenerative therapies for myocardial infarction: exploring the critical role of energy metabolism in achieving cardiac repair |
| title_sort | regenerative therapies for myocardial infarction exploring the critical role of energy metabolism in achieving cardiac repair |
| topic | myocardial infarction cardiomyocyte proliferation cardiac regeneration energy metabolism cell cycle |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1533105/full |
| work_keys_str_mv | AT jiahaoren regenerativetherapiesformyocardialinfarctionexploringthecriticalroleofenergymetabolisminachievingcardiacrepair AT xinzhechen regenerativetherapiesformyocardialinfarctionexploringthecriticalroleofenergymetabolisminachievingcardiacrepair AT taowang regenerativetherapiesformyocardialinfarctionexploringthecriticalroleofenergymetabolisminachievingcardiacrepair AT cuiyunliu regenerativetherapiesformyocardialinfarctionexploringthecriticalroleofenergymetabolisminachievingcardiacrepair AT kunwang regenerativetherapiesformyocardialinfarctionexploringthecriticalroleofenergymetabolisminachievingcardiacrepair |