Dysregulated macrophage immunity in Helicobacter pylori infection: unveiling mechanistic insights and therapeutic implications

Dysregulated macrophage immunity in Helicobacter pylori infection: unveiling mechanistic insights and therapeutic implications

Helicobacter pylori (H. pylori) is a microaerophilic, gram-negative spirochete that primarily colonizes the human gastric mucosa. It is strongly linked to gastritis, ulcers, and the development of malignant tumors. Macrophages, as one of the key components of the innate immune system, play a crucial...

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Bibliographic Details
Main Authors: Miao Xiang, Panpan Li, Xiaofei Yue, Linlin Liu, Linjing Wang, Nengjin Sun, Kaile Wang, Yuying Zhang, Hongyan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
Helicobacter pylori
macrophages
phagocytosis
inflammation
antigen presentation
immunomodulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1636768/full
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