Carotid intima-media thickness and risk of atherosclerosis in multiple sclerosis: A cross-sectional study.
<h4>Background</h4>Multiple sclerosis (MS) is characterized by inflammation and demyelination in the central nervous system. Recent studies have suggested a potential association between MS and an increased risk of atherosclerosis, a systemic vascular disease involving arterial wall thic...
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Public Library of Science (PLoS)
2024-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0314031 |
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| author | Elyar Alizadeh Najmi Zahra Mirzaasgari Mohammad Reza Motamed Armin Aslani |
| author_facet | Elyar Alizadeh Najmi Zahra Mirzaasgari Mohammad Reza Motamed Armin Aslani |
| author_sort | Elyar Alizadeh Najmi |
| collection | DOAJ |
| description | <h4>Background</h4>Multiple sclerosis (MS) is characterized by inflammation and demyelination in the central nervous system. Recent studies have suggested a potential association between MS and an increased risk of atherosclerosis, a systemic vascular disease involving arterial wall thickening. Understanding this relationship is crucial, given the heightened cardiovascular risk observed in MS patients.<h4>Objective</h4>To investigate factors influencing the development of atherosclerosis in patients with multiple sclerosis (pwMS), focusing on carotid intima-media thickness (CIMT) as a marker.<h4>Methods</h4>114 pwMS (82 females and 32 males) and 127 control subjects (57 females and 70 males) were included. The mean CIMT between the two groups was compared. Additionally, the effects of annual relapse rate, EDSS (Expanded Disability Status Scale), MS duration, treatment duration, and type of Disease-modifying treatment (DMT) on CIMT were evaluated.<h4>Results</h4>This study included 241 participants with a mean (SD) age of 41.13 years (10.93). CIMT was significantly higher in pwMS compared to controls (p < 0.001). Even after adjusting for age, sex, and BMI (Body Mass Index), CIMT remained significantly higher in the pwMS group (p < 0.001). Spearman's correlation analysis revealed significant associations between CIMT and age, BMI, EDSS score, and disease duration (all p < 0.05). Additionally, the SPMS (Secondary Progressive Multiple Sclerosis) disease course was significantly associated with higher CIMT (p < 0.001). Linear regression analysis identified age as the most significant predictor of increased CIMT in pwMS (p < 0.001), followed by BMI (p = 0.054).<h4>Conclusion</h4>This study demonstrates a significant association between MS and increased CIMT. Additionally, age emerged as the most prominent predictor of high CIMT in pwMS, followed by BMI. These findings suggest a potential link between MS and increased cardiovascular risk. Further research is warranted to explore the underlying mechanisms and investigate the long-term cardiovascular outcomes in this population. |
| format | Article |
| id | doaj-art-fbb35e08e69543f1b2711f907a6c7e2c |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-fbb35e08e69543f1b2711f907a6c7e2c2024-11-23T05:30:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-011911e031403110.1371/journal.pone.0314031Carotid intima-media thickness and risk of atherosclerosis in multiple sclerosis: A cross-sectional study.Elyar Alizadeh NajmiZahra MirzaasgariMohammad Reza MotamedArmin Aslani<h4>Background</h4>Multiple sclerosis (MS) is characterized by inflammation and demyelination in the central nervous system. Recent studies have suggested a potential association between MS and an increased risk of atherosclerosis, a systemic vascular disease involving arterial wall thickening. Understanding this relationship is crucial, given the heightened cardiovascular risk observed in MS patients.<h4>Objective</h4>To investigate factors influencing the development of atherosclerosis in patients with multiple sclerosis (pwMS), focusing on carotid intima-media thickness (CIMT) as a marker.<h4>Methods</h4>114 pwMS (82 females and 32 males) and 127 control subjects (57 females and 70 males) were included. The mean CIMT between the two groups was compared. Additionally, the effects of annual relapse rate, EDSS (Expanded Disability Status Scale), MS duration, treatment duration, and type of Disease-modifying treatment (DMT) on CIMT were evaluated.<h4>Results</h4>This study included 241 participants with a mean (SD) age of 41.13 years (10.93). CIMT was significantly higher in pwMS compared to controls (p < 0.001). Even after adjusting for age, sex, and BMI (Body Mass Index), CIMT remained significantly higher in the pwMS group (p < 0.001). Spearman's correlation analysis revealed significant associations between CIMT and age, BMI, EDSS score, and disease duration (all p < 0.05). Additionally, the SPMS (Secondary Progressive Multiple Sclerosis) disease course was significantly associated with higher CIMT (p < 0.001). Linear regression analysis identified age as the most significant predictor of increased CIMT in pwMS (p < 0.001), followed by BMI (p = 0.054).<h4>Conclusion</h4>This study demonstrates a significant association between MS and increased CIMT. Additionally, age emerged as the most prominent predictor of high CIMT in pwMS, followed by BMI. These findings suggest a potential link between MS and increased cardiovascular risk. Further research is warranted to explore the underlying mechanisms and investigate the long-term cardiovascular outcomes in this population.https://doi.org/10.1371/journal.pone.0314031 |
| spellingShingle | Elyar Alizadeh Najmi Zahra Mirzaasgari Mohammad Reza Motamed Armin Aslani Carotid intima-media thickness and risk of atherosclerosis in multiple sclerosis: A cross-sectional study. PLoS ONE |
| title | Carotid intima-media thickness and risk of atherosclerosis in multiple sclerosis: A cross-sectional study. |
| title_full | Carotid intima-media thickness and risk of atherosclerosis in multiple sclerosis: A cross-sectional study. |
| title_fullStr | Carotid intima-media thickness and risk of atherosclerosis in multiple sclerosis: A cross-sectional study. |
| title_full_unstemmed | Carotid intima-media thickness and risk of atherosclerosis in multiple sclerosis: A cross-sectional study. |
| title_short | Carotid intima-media thickness and risk of atherosclerosis in multiple sclerosis: A cross-sectional study. |
| title_sort | carotid intima media thickness and risk of atherosclerosis in multiple sclerosis a cross sectional study |
| url | https://doi.org/10.1371/journal.pone.0314031 |
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