Autophagy: More Than a Nonselective Pathway
Autophagy is a catabolic pathway conserved among eukaryotes that allows cells to rapidly eliminate large unwanted structures such as aberrant protein aggregates, superfluous or damaged organelles, and invading pathogens. The hallmark of this transport pathway is the sequestration of the cargoes that...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/219625 |
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| _version_ | 1832552336085483520 |
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| author | Fulvio Reggiori Masaaki Komatsu Kim Finley Anne Simonsen |
| author_facet | Fulvio Reggiori Masaaki Komatsu Kim Finley Anne Simonsen |
| author_sort | Fulvio Reggiori |
| collection | DOAJ |
| description | Autophagy is a catabolic pathway conserved among eukaryotes that allows cells to rapidly eliminate large unwanted structures such as aberrant protein aggregates, superfluous or damaged organelles, and invading pathogens. The hallmark of this transport pathway is the sequestration of the cargoes that have to be degraded in the lysosomes by double-membrane vesicles called autophagosomes. The key actors mediating the biogenesis of these carriers are the autophagy-related genes (ATGs). For a long time, it was assumed that autophagy is a bulk process. Recent studies, however, have highlighted the capacity of this pathway to exclusively eliminate specific structures and thus better fulfil the catabolic necessities of the cell. We are just starting to unveil the regulation and mechanism of these selective types of autophagy, but what it is already clearly emerging is that structures targeted to destruction are accurately enwrapped by autophagosomes through the action of specific receptors and adaptors. In this paper, we will briefly discuss the impact that the selective types of autophagy have had on our understanding of autophagy. |
| format | Article |
| id | doaj-art-fb9f72cfbef245e4a58b5dbf04e93828 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-fb9f72cfbef245e4a58b5dbf04e938282025-02-03T05:59:00ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/219625219625Autophagy: More Than a Nonselective PathwayFulvio Reggiori0Masaaki Komatsu1Kim Finley2Anne Simonsen3Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, 3584 CX Utrecht, The NetherlandsProtein Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, JapanBioScience Center, San Diego State University, San Diego, CA 921825, USADepartment of Biochemistry, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, 0317 Oslo, NorwayAutophagy is a catabolic pathway conserved among eukaryotes that allows cells to rapidly eliminate large unwanted structures such as aberrant protein aggregates, superfluous or damaged organelles, and invading pathogens. The hallmark of this transport pathway is the sequestration of the cargoes that have to be degraded in the lysosomes by double-membrane vesicles called autophagosomes. The key actors mediating the biogenesis of these carriers are the autophagy-related genes (ATGs). For a long time, it was assumed that autophagy is a bulk process. Recent studies, however, have highlighted the capacity of this pathway to exclusively eliminate specific structures and thus better fulfil the catabolic necessities of the cell. We are just starting to unveil the regulation and mechanism of these selective types of autophagy, but what it is already clearly emerging is that structures targeted to destruction are accurately enwrapped by autophagosomes through the action of specific receptors and adaptors. In this paper, we will briefly discuss the impact that the selective types of autophagy have had on our understanding of autophagy.http://dx.doi.org/10.1155/2012/219625 |
| spellingShingle | Fulvio Reggiori Masaaki Komatsu Kim Finley Anne Simonsen Autophagy: More Than a Nonselective Pathway International Journal of Cell Biology |
| title | Autophagy: More Than a Nonselective Pathway |
| title_full | Autophagy: More Than a Nonselective Pathway |
| title_fullStr | Autophagy: More Than a Nonselective Pathway |
| title_full_unstemmed | Autophagy: More Than a Nonselective Pathway |
| title_short | Autophagy: More Than a Nonselective Pathway |
| title_sort | autophagy more than a nonselective pathway |
| url | http://dx.doi.org/10.1155/2012/219625 |
| work_keys_str_mv | AT fulvioreggiori autophagymorethananonselectivepathway AT masaakikomatsu autophagymorethananonselectivepathway AT kimfinley autophagymorethananonselectivepathway AT annesimonsen autophagymorethananonselectivepathway |