Impact of drug-resistant tuberculosis on socio-economic status, quality of life and psychological well-being of patients in Bucharest, Romania: a prospective cohort study
Abstract Background Tuberculosis (TB) remains a global health challenge, with 1.3 million deaths in 2022. Ten countries in the European Union (EU) and European Economic Area (EEA) accounted for 88.3% of TB cases, of which 23.8% were from Romania. Evidence shows that mental health issues, decreased q...
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BMC
2024-12-01
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| Series: | Journal of Health, Population and Nutrition |
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| Online Access: | https://doi.org/10.1186/s41043-024-00717-x |
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| author | Rupa Ramachandran Andreea Dumitrescu Dragos Baiceanu Cristina Popa Antonela Dragomir Beatrice Mahler Michael Hoelscher Christoph Lange Jan Heyckendorf Andrea Rachow Elmira Ibraim Olena Ivanova |
| author_facet | Rupa Ramachandran Andreea Dumitrescu Dragos Baiceanu Cristina Popa Antonela Dragomir Beatrice Mahler Michael Hoelscher Christoph Lange Jan Heyckendorf Andrea Rachow Elmira Ibraim Olena Ivanova |
| author_sort | Rupa Ramachandran |
| collection | DOAJ |
| description | Abstract Background Tuberculosis (TB) remains a global health challenge, with 1.3 million deaths in 2022. Ten countries in the European Union (EU) and European Economic Area (EEA) accounted for 88.3% of TB cases, of which 23.8% were from Romania. Evidence shows that mental health issues, decreased quality of life and negative socio-economic impact are common among TB patients; however, there is limited evidence available in Romania. The main aim of this study is to longitudinally assess the quality of life, mental health, and socio-economic status of patients with drug-resistant TB (DR TB) in Romania. Methods A prospective cohort study was conducted at the Marius Nasta Institute of Pneumology in Bucharest, Romania, enrolling 50 participants with DR TB. Demographic data, clinical examinations, laboratory test and medical history were recorded at study start. At baseline (week two), month 10, and month 20 we also administered the Short-Form-36 and Kessler Psychological Distress Scale to assess health-related quality of life and mental health status, and socio-economic questionnaires to 46 participants. Results Of the 46 participants with median age of 48.9 years, 71.7% were males. Majority of the participants were employed at the baseline but due to the rigorous treatment and hospitalization had to take sick leave, thereby affecting the individual and household income. 26.1% and 39.3% of participants reported psychological distress at baseline and at the end of month 20, respectively. The quality-of-life scores improved during treatment: PCS with a mean of 67.0 (SD-33.9) at baseline, 63.3 (SD-31.9) at month 10 and 70.3 (SD-30.3) at month 20, and MCS with 62.8 (SD-30.6), 67.8 (SD-29) and 70.8 (SD-27.3), accordingly, but differences were not significant. Conclusions We examined the socio-economic impact, quality of life, and psychological distress among patients affected by DR TB in Romania. The results of this study suggest that social and psychological support will ensure a better standard of living during and following TB treatment. |
| format | Article |
| id | doaj-art-fb9bad84e1ba4366a1fe9bcfce5e0827 |
| institution | Kabale University |
| issn | 2072-1315 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
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| series | Journal of Health, Population and Nutrition |
| spelling | doaj-art-fb9bad84e1ba4366a1fe9bcfce5e08272024-12-29T12:37:00ZengBMCJournal of Health, Population and Nutrition2072-13152024-12-0143111110.1186/s41043-024-00717-xImpact of drug-resistant tuberculosis on socio-economic status, quality of life and psychological well-being of patients in Bucharest, Romania: a prospective cohort studyRupa Ramachandran0Andreea Dumitrescu1Dragos Baiceanu2Cristina Popa3Antonela Dragomir4Beatrice Mahler5Michael Hoelscher6Christoph Lange7Jan Heyckendorf8Andrea Rachow9Elmira Ibraim10Olena Ivanova11Deggendorf Institute of Technology, European Campus Rottal-InnMarius Nasta Institute of Pneumology - German Centre for Infection Research (DZIF), Eastern European Study SiteMarius Nasta Institute of Pneumology - German Centre for Infection Research (DZIF), Eastern European Study SiteMarius Nasta Institute of Pneumology - German Centre for Infection Research (DZIF), Eastern European Study SiteMarius Nasta Institute of Pneumology - German Centre for Infection Research (DZIF), Eastern European Study SiteMarius Nasta Institute of Pneumology - German Centre for Infection Research (DZIF), Eastern European Study SiteInstitute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU MunichDivision of Clinical Infectious Diseases, Research Center BorstelDepartment of Internal Medicine I, Kiel University and University Medical Center Schleswig-HolsteinInstitute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU MunichMarius Nasta Institute of Pneumology - German Centre for Infection Research (DZIF), Eastern European Study SiteInstitute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU MunichAbstract Background Tuberculosis (TB) remains a global health challenge, with 1.3 million deaths in 2022. Ten countries in the European Union (EU) and European Economic Area (EEA) accounted for 88.3% of TB cases, of which 23.8% were from Romania. Evidence shows that mental health issues, decreased quality of life and negative socio-economic impact are common among TB patients; however, there is limited evidence available in Romania. The main aim of this study is to longitudinally assess the quality of life, mental health, and socio-economic status of patients with drug-resistant TB (DR TB) in Romania. Methods A prospective cohort study was conducted at the Marius Nasta Institute of Pneumology in Bucharest, Romania, enrolling 50 participants with DR TB. Demographic data, clinical examinations, laboratory test and medical history were recorded at study start. At baseline (week two), month 10, and month 20 we also administered the Short-Form-36 and Kessler Psychological Distress Scale to assess health-related quality of life and mental health status, and socio-economic questionnaires to 46 participants. Results Of the 46 participants with median age of 48.9 years, 71.7% were males. Majority of the participants were employed at the baseline but due to the rigorous treatment and hospitalization had to take sick leave, thereby affecting the individual and household income. 26.1% and 39.3% of participants reported psychological distress at baseline and at the end of month 20, respectively. The quality-of-life scores improved during treatment: PCS with a mean of 67.0 (SD-33.9) at baseline, 63.3 (SD-31.9) at month 10 and 70.3 (SD-30.3) at month 20, and MCS with 62.8 (SD-30.6), 67.8 (SD-29) and 70.8 (SD-27.3), accordingly, but differences were not significant. Conclusions We examined the socio-economic impact, quality of life, and psychological distress among patients affected by DR TB in Romania. The results of this study suggest that social and psychological support will ensure a better standard of living during and following TB treatment.https://doi.org/10.1186/s41043-024-00717-xTuberculosisDrug-resistantQuality of lifePsychological distressSocio-economic impact |
| spellingShingle | Rupa Ramachandran Andreea Dumitrescu Dragos Baiceanu Cristina Popa Antonela Dragomir Beatrice Mahler Michael Hoelscher Christoph Lange Jan Heyckendorf Andrea Rachow Elmira Ibraim Olena Ivanova Impact of drug-resistant tuberculosis on socio-economic status, quality of life and psychological well-being of patients in Bucharest, Romania: a prospective cohort study Journal of Health, Population and Nutrition Tuberculosis Drug-resistant Quality of life Psychological distress Socio-economic impact |
| title | Impact of drug-resistant tuberculosis on socio-economic status, quality of life and psychological well-being of patients in Bucharest, Romania: a prospective cohort study |
| title_full | Impact of drug-resistant tuberculosis on socio-economic status, quality of life and psychological well-being of patients in Bucharest, Romania: a prospective cohort study |
| title_fullStr | Impact of drug-resistant tuberculosis on socio-economic status, quality of life and psychological well-being of patients in Bucharest, Romania: a prospective cohort study |
| title_full_unstemmed | Impact of drug-resistant tuberculosis on socio-economic status, quality of life and psychological well-being of patients in Bucharest, Romania: a prospective cohort study |
| title_short | Impact of drug-resistant tuberculosis on socio-economic status, quality of life and psychological well-being of patients in Bucharest, Romania: a prospective cohort study |
| title_sort | impact of drug resistant tuberculosis on socio economic status quality of life and psychological well being of patients in bucharest romania a prospective cohort study |
| topic | Tuberculosis Drug-resistant Quality of life Psychological distress Socio-economic impact |
| url | https://doi.org/10.1186/s41043-024-00717-x |
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