Protective Effects of Curcumin and Resveratrol on Kidney Tissue on Cadmium-induced Oxidative Stress in Rats
Objective: Cadmium (Cd) is a well-known widespread environmental pollutant and is not rapidly excreted by the kidneys; instead, it accumulates and causes kidney damage. This study aimed to compare the effects of antioxidant curcumin and resveratrol on antioxidant defense in Cd-induced rat kidney tis...
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| Language: | English |
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Galenos Publishing House
2024-04-01
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| Series: | Gazi Medical Journal |
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| Online Access: | https://gazimedj.com/articles/protective-effects-of-curcumin-and-resveratrol-on-kidney-tissue-on-cadmium-induced-oxidative-stress-in-rats/doi/gmj.2023.3705 |
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| _version_ | 1841525590635577344 |
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| author | Suat Cakina Latife Ceyda İrkin Şamil Öztürk |
| author_facet | Suat Cakina Latife Ceyda İrkin Şamil Öztürk |
| author_sort | Suat Cakina |
| collection | DOAJ |
| description | Objective: Cadmium (Cd) is a well-known widespread environmental pollutant and is not rapidly excreted by the kidneys; instead, it accumulates and causes kidney damage. This study aimed to compare the effects of antioxidant curcumin and resveratrol on antioxidant defense in Cd-induced rat kidney tissue.
Methods: In the study, 36 (200-250 gr) Wistar albino rats were divided into 6 (n=6) groups. Group 1: control; group 2: CdCl2; group 3: curcumin; group 4: CdCl2 + curcumin; group 5: resveratrol; group 6: CdCl2 + resveratrol. At the end of the experiment, malondialdehyde (MDA), total oxidant capacity (TOC), and total antioxidant capacity (TAC) activities were measured in kidney tissues.
Results: In the CdCl2-treated group, oxidative stress index (OSI), TOC, and MDA levels increased compared with the control group, and TAC values decreased (p<0.05). In the case of resveratrol or curcumin administered with Cd, TAC levels increased, MDA levels, and OSI values decreased compared with the group administered only Cd (p<0.05).
Conclusion: Both resveratrol and curcumin may have protective effects in the kidneys against CdCl2-induced oxidative damage. |
| format | Article |
| id | doaj-art-fb99d3ace8874734a664ffaeb5cba246 |
| institution | Kabale University |
| issn | 2147-2092 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Gazi Medical Journal |
| spelling | doaj-art-fb99d3ace8874734a664ffaeb5cba2462025-01-17T10:21:46ZengGalenos Publishing HouseGazi Medical Journal2147-20922024-04-0135214514810.12996/gmj.2023.3705Protective Effects of Curcumin and Resveratrol on Kidney Tissue on Cadmium-induced Oxidative Stress in RatsSuat Cakina0https://orcid.org/0000-0002-3990-7641Latife Ceyda İrkin1https://orcid.org/0000-0001-6603-8413Şamil Öztürk2https://orcid.org/0000-0002-9435-8139Çanakkale Onsekiz Mart University, Health Service Vocational College, Çanakkale, TürkiyeÇanakkale Onsekiz Mart University, Çanakkale Faculty of Applied Sciences, Department of Fisheries Technology, Çanakkale, TürkiyeÇanakkale Onsekiz Mart University, Health Service Vocational College, Çanakkale, TürkiyeObjective: Cadmium (Cd) is a well-known widespread environmental pollutant and is not rapidly excreted by the kidneys; instead, it accumulates and causes kidney damage. This study aimed to compare the effects of antioxidant curcumin and resveratrol on antioxidant defense in Cd-induced rat kidney tissue. Methods: In the study, 36 (200-250 gr) Wistar albino rats were divided into 6 (n=6) groups. Group 1: control; group 2: CdCl2; group 3: curcumin; group 4: CdCl2 + curcumin; group 5: resveratrol; group 6: CdCl2 + resveratrol. At the end of the experiment, malondialdehyde (MDA), total oxidant capacity (TOC), and total antioxidant capacity (TAC) activities were measured in kidney tissues. Results: In the CdCl2-treated group, oxidative stress index (OSI), TOC, and MDA levels increased compared with the control group, and TAC values decreased (p<0.05). In the case of resveratrol or curcumin administered with Cd, TAC levels increased, MDA levels, and OSI values decreased compared with the group administered only Cd (p<0.05). Conclusion: Both resveratrol and curcumin may have protective effects in the kidneys against CdCl2-induced oxidative damage.https://gazimedj.com/articles/protective-effects-of-curcumin-and-resveratrol-on-kidney-tissue-on-cadmium-induced-oxidative-stress-in-rats/doi/gmj.2023.3705cadmiumcurcuminresveratrolkidney damage |
| spellingShingle | Suat Cakina Latife Ceyda İrkin Şamil Öztürk Protective Effects of Curcumin and Resveratrol on Kidney Tissue on Cadmium-induced Oxidative Stress in Rats Gazi Medical Journal cadmium curcumin resveratrol kidney damage |
| title | Protective Effects of Curcumin and Resveratrol on Kidney Tissue on Cadmium-induced Oxidative Stress in Rats |
| title_full | Protective Effects of Curcumin and Resveratrol on Kidney Tissue on Cadmium-induced Oxidative Stress in Rats |
| title_fullStr | Protective Effects of Curcumin and Resveratrol on Kidney Tissue on Cadmium-induced Oxidative Stress in Rats |
| title_full_unstemmed | Protective Effects of Curcumin and Resveratrol on Kidney Tissue on Cadmium-induced Oxidative Stress in Rats |
| title_short | Protective Effects of Curcumin and Resveratrol on Kidney Tissue on Cadmium-induced Oxidative Stress in Rats |
| title_sort | protective effects of curcumin and resveratrol on kidney tissue on cadmium induced oxidative stress in rats |
| topic | cadmium curcumin resveratrol kidney damage |
| url | https://gazimedj.com/articles/protective-effects-of-curcumin-and-resveratrol-on-kidney-tissue-on-cadmium-induced-oxidative-stress-in-rats/doi/gmj.2023.3705 |
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