The role of Latin America medicinal plants in wound healing
Wound healing represents a global public health problem when it is not treated correctly, which can cause complications for the patient, such as functional loss of an organ, amputation, and even death. At a biological level, wound healing involves a complex mechanism in which the immune system and c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Chemical Engineering |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fceng.2024.1514962/full |
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| author | Mariana Sánchez-Ramos Andrea Ruiz-Betancourt Stephany Abigail Tadeo-Cuenca Angélica Román-Guerrero María Crystal Columba-Palomares Araceli Guerrero-Alonso Antonio Bernabé-Antonio Deyanira Ojeda-Ramírez Francisco Cruz-Sosa |
| author_facet | Mariana Sánchez-Ramos Andrea Ruiz-Betancourt Stephany Abigail Tadeo-Cuenca Angélica Román-Guerrero María Crystal Columba-Palomares Araceli Guerrero-Alonso Antonio Bernabé-Antonio Deyanira Ojeda-Ramírez Francisco Cruz-Sosa |
| author_sort | Mariana Sánchez-Ramos |
| collection | DOAJ |
| description | Wound healing represents a global public health problem when it is not treated correctly, which can cause complications for the patient, such as functional loss of an organ, amputation, and even death. At a biological level, wound healing involves a complex mechanism in which the immune system and cellular biochemical cascades intervene in a coordinated manner, whose development occurs in stages such as inflammation, proliferation, and remodeling. Therefore, therapies have been developed to accelerate wound healing and have proven effective. However, factors such as diabetes mellitus limit the healing process because it causes alterations in microvascular dysfunction, as well as in the inflammatory response and greater oxidative stress. This is reflected in an abnormal healing process; therefore, the search for healing compounds has become an area of interest. In this regard, medicinal plants have been used for centuries to treat wounds in different cultures in the world. Hence, this review documents the main plant species used in Latin America due to its great biodiversity and numerous species that are potentially important for the development of new active healing compounds. In this review, 62 plant families with wound healing studies were found, highlighting Fabaceae, Asteraceae and Euphorbiaceae family. Additionally, 32 natural compounds with diverse structural nature were found, whose effects have been evaluated in in vivo and in vitro models, which are essential for studying the pathogenesis of the tissue repair mechanism, detecting new biomarkers, and evaluate new treatments. Currently, several models are used to study the wound healing process, including in silico, in vitro, and in vivo models. On the other hand, there is no appropriate model to determine the wound healing effect, and, in many cases, they are combined to provide sufficient scientific evidence. Therefore, this review demonstrates that Latin America is a potential region for research into sources of healing molecules. Nevertheless, other species are still being studied whose scientific findings allow generating viable alternatives for the solution of health problems associated with wound healing. |
| format | Article |
| id | doaj-art-fb970ffad7064900b1152e88e026a1f9 |
| institution | Kabale University |
| issn | 2673-2718 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Chemical Engineering |
| spelling | doaj-art-fb970ffad7064900b1152e88e026a1f92025-01-13T05:10:14ZengFrontiers Media S.A.Frontiers in Chemical Engineering2673-27182025-01-01610.3389/fceng.2024.15149621514962The role of Latin America medicinal plants in wound healingMariana Sánchez-Ramos0Andrea Ruiz-Betancourt1Stephany Abigail Tadeo-Cuenca2Angélica Román-Guerrero3María Crystal Columba-Palomares4Araceli Guerrero-Alonso5Antonio Bernabé-Antonio6Deyanira Ojeda-Ramírez7Francisco Cruz-Sosa8Department of Biotechnology Autonomous Metropolitan, University-Iztapalapa Campus, México, MexicoDepartment of Biotechnology Autonomous Metropolitan, University-Iztapalapa Campus, México, MexicoDepartment of Biotechnology Autonomous Metropolitan, University-Iztapalapa Campus, México, MexicoDepartment of Biotechnology Autonomous Metropolitan, University-Iztapalapa Campus, México, MexicoFaculty of Pharmacy, Autonomous University of the State of Morelos, Cuernavaca, Morelos, MexicoChemical Research Center-IICBA, Autonomous University of the State of Morelos, Cuernavaca, MexicoDepartment of Wood, Pulp and Paper, University Center of Exact Sciences and Engineering, University of Guadalajara, Zapopan, Jalisco, MexicoAcademic Area of Veterinary Medicine and Animal Husbandry, Institute of Agricultural Sciences, Autonomous University of the State of Hidalgo, Tulancingo, MexicoDepartment of Biotechnology Autonomous Metropolitan, University-Iztapalapa Campus, México, MexicoWound healing represents a global public health problem when it is not treated correctly, which can cause complications for the patient, such as functional loss of an organ, amputation, and even death. At a biological level, wound healing involves a complex mechanism in which the immune system and cellular biochemical cascades intervene in a coordinated manner, whose development occurs in stages such as inflammation, proliferation, and remodeling. Therefore, therapies have been developed to accelerate wound healing and have proven effective. However, factors such as diabetes mellitus limit the healing process because it causes alterations in microvascular dysfunction, as well as in the inflammatory response and greater oxidative stress. This is reflected in an abnormal healing process; therefore, the search for healing compounds has become an area of interest. In this regard, medicinal plants have been used for centuries to treat wounds in different cultures in the world. Hence, this review documents the main plant species used in Latin America due to its great biodiversity and numerous species that are potentially important for the development of new active healing compounds. In this review, 62 plant families with wound healing studies were found, highlighting Fabaceae, Asteraceae and Euphorbiaceae family. Additionally, 32 natural compounds with diverse structural nature were found, whose effects have been evaluated in in vivo and in vitro models, which are essential for studying the pathogenesis of the tissue repair mechanism, detecting new biomarkers, and evaluate new treatments. Currently, several models are used to study the wound healing process, including in silico, in vitro, and in vivo models. On the other hand, there is no appropriate model to determine the wound healing effect, and, in many cases, they are combined to provide sufficient scientific evidence. Therefore, this review demonstrates that Latin America is a potential region for research into sources of healing molecules. Nevertheless, other species are still being studied whose scientific findings allow generating viable alternatives for the solution of health problems associated with wound healing.https://www.frontiersin.org/articles/10.3389/fceng.2024.1514962/fullwound healingmedicinal plantsbiological assaysnatural productsbiodiversity |
| spellingShingle | Mariana Sánchez-Ramos Andrea Ruiz-Betancourt Stephany Abigail Tadeo-Cuenca Angélica Román-Guerrero María Crystal Columba-Palomares Araceli Guerrero-Alonso Antonio Bernabé-Antonio Deyanira Ojeda-Ramírez Francisco Cruz-Sosa The role of Latin America medicinal plants in wound healing Frontiers in Chemical Engineering wound healing medicinal plants biological assays natural products biodiversity |
| title | The role of Latin America medicinal plants in wound healing |
| title_full | The role of Latin America medicinal plants in wound healing |
| title_fullStr | The role of Latin America medicinal plants in wound healing |
| title_full_unstemmed | The role of Latin America medicinal plants in wound healing |
| title_short | The role of Latin America medicinal plants in wound healing |
| title_sort | role of latin america medicinal plants in wound healing |
| topic | wound healing medicinal plants biological assays natural products biodiversity |
| url | https://www.frontiersin.org/articles/10.3389/fceng.2024.1514962/full |
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